Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Matthias Kästle"'
Autor:
Matthias Kästle, Camilla Merten, Roland Hartig, Carlos Plaza-Sirvent, Ingo Schmitz, Ursula Bommhardt, Burkhart Schraven, Luca Simeoni
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 7271 (2022)
Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its pivotal role, ablation of Lck results in a profound block of T-cell development. Here, we sh
Externí odkaz:
https://doaj.org/article/551d2a0fdc9c41669a8d33a3d70f7836
Autor:
Sarah Kowallik, Andreas Kritikos, Matthias Kästle, Christoph Thurm, Burkhart Schraven, Luca Simeoni
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 126 (2020)
Lymphocyte-specific protein tyrosine kinase (Lck) is a pivotal tyrosine kinase involved in T cell receptor (TCR) signaling. Because of its importance, the activity of Lck is regulated at different levels including phosphorylation of tyrosine residues
Externí odkaz:
https://doaj.org/article/58f6ad4a64be448788a27dd9333e62df
Autor:
Matthias, Kästle, Camilla, Merten, Roland, Hartig, Carlos, Plaza-Sirvent, Ingo, Schmitz, Ursula, Bommhardt, Burkhart, Schraven, Luca, Simeoni
Publikováno v:
International journal of molecular sciences. 23(13)
Signaling via the TCR, which is initiated by the Src-family tyrosine kinase Lck, is crucial for the determination of cell fates in the thymus. Because of its pivotal role, ablation of Lck results in a profound block of T-cell development. Here, we sh
Autor:
Matthias Kästle, Werner Zuschratter, Burkhart Schraven, Roland Hartig, Janine Gumz, Andreas Kritikos, Yury Prokazov, André Weber, Evgeny Turbin, Lars Philipsen, Amarendra V. Reddycherla, Luca Simeoni, Andreas Müller, Mateusz Poltorak
Publikováno v:
Science Signaling. 10
The tyrosine kinase Lck is critical to T cell activation in response to stimulation of the T cell receptor (TCR). Lck activity is tightly regulated to avoid inappropriate activation of T cells and subsequent inflammation. Phosphorylation of Tyr505 ca