Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Matthias J. Knape"'
Autor:
Matthias J. Knape, Maximilian Wallbott, Nicole C. G. Burghardt, Daniela Bertinetti, Jan Hornung, Sven H. Schmidt, Robin Lorenz, Friedrich W. Herberg
Publikováno v:
Cells, Vol 9, Iss 6, p 1548 (2020)
cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of
Externí odkaz:
https://doaj.org/article/805e36a159e441b8a7fbffef26b07b35
Autor:
Jascha T. Manschwetus, George N. Bendzunas, Ameya J. Limaye, Matthias J. Knape, Friedrich W. Herberg, Eileen J. Kennedy
Publikováno v:
Molecules, Vol 24, Iss 8, p 1567 (2019)
Kinases regulate multiple and diverse signaling pathways and misregulation is implicated in a multitude of diseases. Although significant efforts have been put forth to develop kinase-specific inhibitors, specificity remains a challenge. As an altern
Externí odkaz:
https://doaj.org/article/5eb2063f144942af9d2b00bd2adc6a35
Autor:
Ping Zhang, Matthias J Knape, Lalima G Ahuja, Malik M Keshwani, Charles C King, Mira Sastri, Friedrich W Herberg, Susan S Taylor
Publikováno v:
PLoS Biology, Vol 13, Iss 7, p e1002192 (2015)
To provide tight spatiotemporal signaling control, the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) holoenzyme typically nucleates a macromolecular complex or a "PKA signalosome." Using the RIIβ holoenzyme as a prototype, we
Externí odkaz:
https://doaj.org/article/f3af226096054bbfacdf5c8046e4a3ce
Autor:
Alexander Jung, Matthias J. Knape, Jens Smiatek, Ramón Alain Miranda-Quintana, Virginia Mazzini, Vincent S. J. Craig, Erich Bluhmki, Jiyoung Yang, Oliver Burkert
Publikováno v:
Physical chemistry chemical physics : PCCP. 22(42)
The knowledge of thermodynamic properties for novel electrolyte formulations is of fundamental interest for industrial applications as well as academic research. Herewith, we present an artificial neural networks (ANN) approach for the prediction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e051525b94389510379898d90708c5
https://pubmed.ncbi.nlm.nih.gov/33084665
https://pubmed.ncbi.nlm.nih.gov/33084665
Autor:
Jan Hasenauer, Tim Hucho, Jörg Isensee, Humberto Gonczarowska-Jorge, Friedrich W. Herberg, René P. Zahedi, Frank Schwede, Matthias J. Knape, Hanna Hammerich, Melanie Kaufholz
Publikováno v:
The Journal of Cell Biology
J. Cell Biol. 217, 2167-2184 (2018)
J. Cell Biol. 217, 2167-2184 (2018)
Activity of endogenous protein kinase A (PKA) could never be analyzed directly in the cellular environment. Isensee et al. used antibodies to quantify conformational changes leading to an open conformation of endogenous PKA-II holoenzymes, which allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30631b822930025843be65a446f91c1f
http://europepmc.org/articles/PMC5987717
http://europepmc.org/articles/PMC5987717
Autor:
Friedrich W. Herberg, Matthias J. Knape, Daniela Bertinetti, Alexandr P. Kornev, Bastian Zimmermann, Mike Ballez, Nicole C. G. Burghardt
Publikováno v:
Metallomics. 9:1576-1584
Protein kinases are key enzymes in the regulation of eukaryotic signal transduction. As metalloenzymes they employ divalent cations for catalysis and regulation. We used the catalytic (C) subunit of cAMP-dependent protein kinase (PKA) as a model prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cc2eed669e1a7a6a804d6e2d322791
https://doi.org/10.1039/c7mt00204a
https://doi.org/10.1039/c7mt00204a
Autor:
Mark H. Ellisman, Daniela Boassa, Susan S. Taylor, Alexandr P. Kornev, Sven H. Schmidt, Natascha Mumdey, Friedrich W. Herberg, Matthias J. Knape
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 30
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Little is known about the regulation of Leucine-rich repeat kinase 2 (LRRK2) associated with familial Parkinson’s disease (PD). To test whether the kinase domain drives LRRK2 activation, we applied the spine concept that describes the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58193ad464391fa2c09c9f113885b5ce
https://escholarship.org/uc/item/2wj7c9h7
https://escholarship.org/uc/item/2wj7c9h7
Autor:
Guillaume Assié, Kerstin Bathon, Daniel Abid, Jérôme Bertherat, Marthe Rizk-Rabin, Matthias J. Knape, Constantine A. Stratakis, Friedrich W. Herberg, Guignat L, Windy Luscap-Rondof, S. Faillot, Davide Calebiro, Stéphanie Espiard
Publikováno v:
JCI Insight
JCI Insight, American Society for Clinical Investigation, 2018, 3 (8), ⟨10.1172/jci.insight.98296⟩
JCI Insight, American Society for Clinical Investigation, 2018, 3 (8), ⟨10.1172/jci.insight.98296⟩
Mutations in the gene encoding the protein kinase A (PKA) catalytic subunit α have been found to be responsible for cortisol-producing adenomas (CPAs). In this study, we identified by whole-exome sequencing the somatic mutation p.S54L in the PRKACB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97da04ea422067c8ef69501d3de9eea0
https://hal.archives-ouvertes.fr/hal-02325835
https://hal.archives-ouvertes.fr/hal-02325835
Publikováno v:
ACS infectious diseases. 4(3)
cGMP-dependent protein kinase from Plasmodium falciparum ( PfPKG) plays a crucial role in the sexual as well as the asexual proliferation of this human malaria causing parasite. However, function and regulation of PfPKG are largely unknown. Previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbb511845f3957646073efe03481ddc
https://pubmed.ncbi.nlm.nih.gov/29251493
https://pubmed.ncbi.nlm.nih.gov/29251493
Autor:
Stéphanie Espiard, Davide Calebiro, Simon Faillot, Matthias J. Knape, Daniel Abid, Constantine Stratakis, Guillaume Assié, Jérôme Bertherat, Kerstin Bathon, Friedrich W. Herberg
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d1565ce6a09b977bf57d9c973512c46
https://doi.org/10.1530/endoabs.49.gp28
https://doi.org/10.1530/endoabs.49.gp28