Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Matthias J Reddehase"'
Autor:
Stefan Ebert, Verena Böhm, Julia K Büttner, Wolfram Brune, Melanie M Brinkmann, Rafaela Holtappels, Matthias J Reddehase, Niels A W Lemmermann
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012173 (2024)
CD8 T cells are the predominant effector cells of adaptive immunity in preventing cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection. The mechanism by which CMV-specific, naïve CD8 T cells become primed and clonal
Externí odkaz:
https://doaj.org/article/1200ce28502447d2809beede76445e04
Autor:
Rafaela Holtappels, Sara Becker, Sara Hamdan, Kirsten Freitag, Jürgen Podlech, Niels A Lemmermann, Matthias J Reddehase
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011643 (2023)
Cytomegaloviruses (CMVs) are host species-specific in their replication. It is a hallmark of all CMVs that productive primary infection is controlled by concerted innate and adaptive immune responses in the immunocompetent host. As a result, the infe
Externí odkaz:
https://doaj.org/article/a668b5d6160c4bbd85aac98867b819ba
Autor:
Sebastian Reuter, Niels A W Lemmermann, Joachim Maxeiner, Jürgen Podlech, Hendrik Beckert, Kirsten Freitag, Daniel Teschner, Frederic Ries, Christian Taube, Roland Buhl, Matthias J Reddehase, Rafaela Holtappels
Publikováno v:
PLoS Pathogens, Vol 15, Iss 3, p e1007595 (2019)
Despite a broad cell-type tropism, cytomegalovirus (CMV) is an evidentially pulmonary pathogen. Predilection for the lungs is of medical relevance in immunocompromised recipients of hematopoietic cell transplantation, in whom interstitial CMV pneumon
Externí odkaz:
https://doaj.org/article/594d98e5cf564933bb5d163e94f4266f
Autor:
Baca Chan, Vladimir Gonçalves Magalhães, Niels A W Lemmermann, Vanda Juranić Lisnić, Markus Stempel, Kendra A Bussey, Elisa Reimer, Jürgen Podlech, Stefan Lienenklaus, Matthias J Reddehase, Stipan Jonjić, Melanie M Brinkmann
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006382 (2017)
The type I interferon (IFN) response is imperative for the establishment of the early antiviral immune response. Here we report the identification of the first type I IFN antagonist encoded by murine cytomegalovirus (MCMV) that shuts down signaling f
Externí odkaz:
https://doaj.org/article/e676e4e47d3342539c76ac11fcf03dfc
Autor:
Branka Popovic, Mijo Golemac, Jürgen Podlech, Jelena Zeleznjak, Lidija Bilic-Zulle, Miodrag L Lukic, Luka Cicin-Sain, Matthias J Reddehase, Tim Sparwasser, Astrid Krmpotic, Stipan Jonjic
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006345 (2017)
Regulatory T (Treg) cells dampen an exaggerated immune response to viral infections in order to avoid immunopathology. Cytomegaloviruses (CMVs) are herpesviruses usually causing asymptomatic infection in immunocompetent hosts and induce strong cellul
Externí odkaz:
https://doaj.org/article/95ca1f16da57444fbd63fb9da8ea8c3a
Autor:
Iryna Dekhtiarenko, Robert B Ratts, Renata Blatnik, Lian N Lee, Sonja Fischer, Lisa Borkner, Jennifer D Oduro, Thomas F Marandu, Stephanie Hoppe, Zsolt Ruzsics, Julia K Sonnemann, Mandana Mansouri, Christine Meyer, Niels A W Lemmermann, Rafaela Holtappels, Ramon Arens, Paul Klenerman, Klaus Früh, Matthias J Reddehase, Angelika B Riemer, Luka Cicin-Sain
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006072 (2016)
Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope o
Externí odkaz:
https://doaj.org/article/9a787b2030704af9add09bb205309a6b
Autor:
Simone Thomas, Sebastian Klobuch, Jürgen Podlech, Bodo Plachter, Petra Hoffmann, Angelique Renzaho, Matthias Theobald, Matthias J Reddehase, Wolfgang Herr, Niels A W Lemmermann
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005049 (2015)
Reactivation of human cytomegalovirus (HCMV) can cause severe disease in recipients of hematopoietic stem cell transplantation. Although preclinical research in murine models as well as clinical trials have provided 'proof of concept' for infection c
Externí odkaz:
https://doaj.org/article/579f514b4d28474c89dfe2d10ed17aa1
Autor:
Niels A W Lemmermann, Astrid Krmpotic, Jürgen Podlech, Ilija Brizic, Adrian Prager, Heiko Adler, Astrid Karbach, Yiquan Wu, Stipan Jonjic, Matthias J Reddehase, Barbara Adler
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004640 (2015)
Herpesviruses form different gH/gL virion envelope glycoprotein complexes that serve as entry complexes for mediating viral cell-type tropism in vitro; their roles in vivo, however, remained speculative and can be addressed experimentally only in ani
Externí odkaz:
https://doaj.org/article/4cfa70fcf4814e0a8b00fa1b85951c8e
Autor:
Stefan Ebert, Marc Becker, Niels A W Lemmermann, Julia K Büttner, Anastasija Michel, Christian Taube, Jürgen Podlech, Verena Böhm, Kirsten Freitag, Doris Thomas, Rafaela Holtappels, Matthias J Reddehase, Michael Stassen
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004100 (2014)
The lungs are a noted predilection site of acute, latent, and reactivated cytomegalovirus (CMV) infections. Interstitial pneumonia is the most dreaded manifestation of CMV disease in the immunocompromised host, whereas in the immunocompetent host lun
Externí odkaz:
https://doaj.org/article/646b8fa77a5e4b9eaaf9743aa8e8fb92
Autor:
Felicia M Wagner, Ilija Brizic, Adrian Prager, Tihana Trsan, Maja Arapovic, Niels A W Lemmermann, Jürgen Podlech, Matthias J Reddehase, Frederic Lemnitzer, Jens Bernhard Bosse, Martina Gimpfl, Lisa Marcinowski, Margaret MacDonald, Heiko Adler, Ulrich H Koszinowski, Barbara Adler
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003493 (2013)
Human cytomegalovirus (HCMV) forms two gH/gL glycoprotein complexes, gH/gL/gO and gH/gL/pUL(128,130,131A), which determine the tropism, the entry pathways and the mode of spread of the virus. For murine cytomegalovirus (MCMV), which serves as a model
Externí odkaz:
https://doaj.org/article/6ec46bf2081f4bc6bd859ac26f166b54