Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Matthias Hinterndorfer"'
Autor:
Chrysanthi Kagiou, Jose A. Cisneros, Jakob Farnung, Joanna Liwocha, Fabian Offensperger, Kevin Dong, Ka Yang, Gary Tin, Christina S. Horstmann, Matthias Hinterndorfer, Joao A. Paulo, Natalie S. Scholes, Juan Sanchez Avila, Michaela Fellner, Florian Andersch, J. Thomas Hannich, Johannes Zuber, Stefan Kubicek, Steven P. Gygi, Brenda A. Schulman, Georg E. Winter
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600 human E3 ligases are currently amenable to t
Externí odkaz:
https://doaj.org/article/122c230e01c4426bb2025a22bb1c70c0
Autor:
Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Lara Dötsch, Hana Imrichova, Philipp Lampe, Xiufen Cheng, Soheila Rezaei Adariani, Georg E. Winter, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-i
Externí odkaz:
https://doaj.org/article/8eb4dd1f4c7244f6a4e44f84f7729d66
Autor:
Irene Schwartz, Milica Vunjak, Valentina Budroni, Adriana Cantoran García, Marialaura Mastrovito, Adrian Soderholm, Matthias Hinterndorfer, Melanie de Almeida, Kathrin Hacker, Jingkui Wang, Kimon Froussios, Julian Jude, Thomas Decker, Johannes Zuber, Gijs A Versteeg
Publikováno v:
eLife, Vol 12 (2023)
Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to preventing autoimmunity. Interferon regulatory factor 1 (
Externí odkaz:
https://doaj.org/article/b78e796f47264314bba6c3a34e79b541
Autor:
Thomas Hoffmann, Alexandra Hörmann, Maja Corcokovic, Jakub Zmajkovic, Matthias Hinterndorfer, Jasko Salkanovic, Fiona Spreitzer, Anna Köferle, Katrin Gitschtaler, Alexandra Popa, Sarah Oberndorfer, Florian Andersch, Markus Schaefer, Michaela Fellner, Nicole Budano, Jan G Ruppert, Paolo Chetta, Melanie Wurm, Johannes Zuber, Ralph A Neumüller
Publikováno v:
eLife, Vol 12 (2023)
Loss-of-function genetic tools are widely applied for validating therapeutic targets, but their utility remains limited by incomplete on- and uncontrolled off-target effects. We describe artificial RNA interference (ARTi) based on synthetic, ultra-po
Externí odkaz:
https://doaj.org/article/5be3978b927a49d695b800fdcd6cb2bb
Autor:
Oliver Hsia, Matthias Hinterndorfer, Angus D. Cowan, Kentaro Iso, Tasuku Ishida, Ramasubramanian Sundaramoorthy, Mark A. Nakasone, Andrea Rukavina, Koraljka Husnjak, Martin Wegner, Alejandro Correa-Sáez, Conner Craigon, Chiara Maniaci, Andrea Testa, Manuel Kaulich, Ivan Dikic, Georg E. Winter, Alessio Ciulli
Targeted protein degradation is a drug modality represented by compounds that recruit a target to an E3 ubiquitin ligase to promote target ubiquitination and proteasomal degradation. Historically, the field distinguishes monovalent degraders from bif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::106f28b55a66af1eca1fd1fb3f153a05
https://doi.org/10.1101/2023.02.14.528511
https://doi.org/10.1101/2023.02.14.528511
Autor:
Julian Jude, Michael Schutzbier, Robert Kalis, Matthias Hinterndorfer, Tobias Neumann, Elisabeth Roitinger, Gijs A. Versteeg, Irina Grishkovskaya, Melanie de Almeida, Hanna Brunner, Susanne Kandolf, Richard Imre, Kashish Singh, Sumit Deswal, Karl Mechtler, David Haselbach, Johannes Zuber, Thomas Lendl, Alexander Schleiffer, Milica Vunjak
Publikováno v:
Nature
Protein expression and turnover are controlled through a complex interplay of transcriptional, post-transcriptional and post-translational mechanisms to enable spatial and temporal regulation of cellular processes. To systematically elucidate such ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75dfd4a374c902f202787186c40f7c45
https://doi.org/10.1038/s41586-021-04035-8
https://doi.org/10.1038/s41586-021-04035-8
Autor:
Milica Vunjak, Irene Schwartz, Adriana Cantoran García, Marialaura Mastrovito, Matthias Hinterndorfer, Melanie de Almeida, Valentina Budroni, Jingkui Wang, Kimon Froussios, Julian Jude, Thomas Decker, Johannes Zuber, Gijs A. Versteeg
Adaptation of the functional proteome is essential to counter pathogens during infection, yet precisely timed degradation of these response proteins after pathogen clearance is likewise key to preventing autoimmunity. Interferon Regulatory Factor 1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::722b925f1791a79dcd74c95924ce29e6
https://doi.org/10.1101/2022.10.10.511567
https://doi.org/10.1101/2022.10.10.511567
Autor:
Matthias Hinterndorfer, Max Gijsbertsen, Gintautas Vainorius, Johannes Zuber, Ulrich Elling, Thomas R Burkard, Tobias Neumann, Julian Jude, Maria Hubmann, Michaela Fellner, Alexander Schleiffer, Anna K. Traunbauer, Melanie Talata De Almeida, Georg Michlits
Publikováno v:
Nature Methods. 17:708-716
CRISPR-Cas9 screens have emerged as a transformative approach to systematically probe gene functions. The quality and success of these screens depends on the frequencies of loss-of-function alleles, particularly in negative-selection screens widely a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5796a0c8ff28b9823408cfd369ddbea7
https://doi.org/10.1038/s41592-020-0850-8
https://doi.org/10.1038/s41592-020-0850-8
Autor:
Mark Petronczki, Jan-Michael Peters, Petra van der Lelij, V.L. Katis, Julian Jude, Thomas Hoffmann, Gerd Bader, Johannes Zuber, Matthias Hinterndorfer, Simone Lieb, Opher Gileadi, Mark Pearson, J.A. Newman, Norbert Kraut
Publikováno v:
Life Science Alliance
This work highlights the degradation of STAG1 and inhibition of its interaction with cohesin as promising therapeutic strategies for exploiting synthetic lethality to treat STAG2-mutated tumors and lays the groundwork for the discovery of STAG1-direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce548594eea9cf3b60b702945c16280
Autor:
Daniel Gerlach, Sabine Olt, Stefanie Schlager, Sophia M Blake, Anja Ebert, Manfred Koegl, Oliver Bergner, Johannes Wachter, Anna K. Traunbauer, Mark Pearson, Norbert Kraut, Johannes Zuber, Christoph Albrecht, Barbara Drobits, Norbert Schweifer, Martina Minnich, Vittoria Zinzalla, Francesca Trapani, Matthias Hinterndorfer, Tilman Voss, Julian Jude, Darryl B. McConnell, Carina Salomon
Publikováno v:
Oncotarget
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphomas worldwide and is characterized by a high diversity of genetic and molecular alterations. Chromosomal translocations and mutations leading to deregulated expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e39bab60623b240ea21f21b00de8086
https://pubmed.ncbi.nlm.nih.gov/32180900
https://pubmed.ncbi.nlm.nih.gov/32180900