Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthias Helms"'
Autor:
Juergen Stichler, Peter Kapitan, Laurent Lefort, Richard A. Ward, Thomas Dax, Stefan Abele, Johannes G. de Vries, André H.M. de Vries, Gerard K. M. Verzijl, Wolfgang Skranc, Matthias Helms, Zarghun Nazir, Imboden Christoph
Publikováno v:
Organic Process Research & Development. 17:1531-1539
Several methods are presented for the enantioselective synthesis of the tetrahydroisoquinoline core of almorexant (ACT-078573A), a dual orexin receptor antagonist. Initial clinical supplies were secured by the Noyori Ru-catalyzed asymmetric transfer
Autor:
Hans-Ulrich Reißig, Matthias Helms
Publikováno v:
European Journal of Organic Chemistry. 2005:998-1001
Ozonolysis and subsequent in situ acylation/base treatment converted the enantiopure carbohydrate-derived 1,2-oxaz-ines 1, 5, 8 (either syn- or anti-configured) and anti-11 into the highly functionalized α-amino-β-hydroxy esters 2, 6, 9 and 12 in m
Autor:
Matthias Helms, Hans-Ulrich Reißig, Ahmed Al-Harrasi, Lubor Fišera, G. Zahn, Wolfgang Schade, Robert Pulz, Iva Hlobilova, Toshiko Watanabe
Publikováno v:
European Journal of Organic Chemistry. 2005:1003-1019
Additions of lithiated alkoxyallenes to D-glyceraldehyde-based nitrones 1 and 2 did not provide the expected hydroxylamine derivatives. Instead, a novel [3+3] cyclization process furnished 4-alkoxy-3,6-dihydro-2H-1,2-oxazines 9–14 with excellent sy
Autor:
Ann‐Kathrin Rahm, Matthias Helmschrott, Fabrice F. Darche, Dierk Thomas, Tom Bruckner, Philipp Ehlermann, Michael M. Kreusser, Gregor Warnecke, Norbert Frey, Rasmus Rivinius
Publikováno v:
ESC Heart Failure, Vol 8, Iss 5, Pp 3737-3747 (2021)
Abstract Aims Right bundle branch block (RBBB) after heart transplantation (HTX) is a common finding, but its impact on post‐transplant survival remains uncertain. This study investigated the post‐transplant outcomes of patients with complete RBB
Externí odkaz:
https://doaj.org/article/e658afff72b149a8b46cd136a07a0e6e
Autor:
Fabrice F. Darche, Matthias Helmschrott, Ann‐Kathrin Rahm, Dierk Thomas, Patrick A. Schweizer, Tom Bruckner, Philipp Ehlermann, Michael M. Kreusser, Gregor Warnecke, Norbert Frey, Rasmus Rivinius
Publikováno v:
ESC Heart Failure, Vol 8, Iss 5, Pp 4265-4277 (2021)
Abstract Aims Atrial fibrillation (AF) after heart transplantation (HTX) is associated with worse clinical outcomes. The current study aimed to analyse the association between AF before HTX and AF within 30 days after HTX. Methods and results This st
Externí odkaz:
https://doaj.org/article/bb11f8ff2aa04332ac88b5d9719d29f5
Autor:
Rasmus Rivinius, Carolin Gralla, Matthias Helmschrott, Fabrice F. Darche, Philipp Ehlermann, Tom Bruckner, Wiebke Sommer, Gregor Warnecke, Stefan Kopf, Julia Szendroedi, Norbert Frey, Lars P. Kihm
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
AimsCardiac transplant recipients often suffer from type 2 diabetes mellitus (T2DM) but its influence on graft failure and post-transplant mortality remains unknown. The aim of this study was to investigate the long-term effects of pre-transplant T2D
Externí odkaz:
https://doaj.org/article/31663a49839f4e408b4a6b3038e13ece
Autor:
Robert Pulz, Toshiko Watanabe, Hans-Ulrich Reissig, Iva Hlobilova, Lubor Fisera, Matthias Helms, G. Zahn, Ahmed Al-Harrasi, Wolfgang Schade
Publikováno v:
ChemInform. 36
Autor:
Rasmus Rivinius, Matthias Helmschrott, Ann‐Kathrin Rahm, Fabrice F. Darche, Dierk Thomas, Tom Bruckner, Andreas O. Doesch, Philipp Ehlermann, Hugo A. Katus, Edgar Zitron
Publikováno v:
ESC Heart Failure, Vol 7, Iss 5, Pp 2082-2092 (2020)
Abstract Aims Amiodarone and digitalis are frequently used drugs in patients with heart failure. Both have separately been linked to reduced post‐transplant survival, but their combined impact on mortality after HTX remains uncertain. This study in
Externí odkaz:
https://doaj.org/article/a297b1b3e3dc4e6bbdc12b4d61d785b2
Autor:
Rasmus Rivinius, Matthias Helmschrott, Arjang Ruhparwar, Bastian Schmack, Fabrice F. Darche, Dierk Thomas, Tom Bruckner, Andreas O. Doesch, Hugo A. Katus, Philipp Ehlermann
Publikováno v:
ESC Heart Failure, Vol 7, Iss 1, Pp 177-188 (2020)
Abstract Aims Severely elevated pre‐transplant pulmonary vascular resistance (PVR) has been linked to adverse effects after heart transplantation (HTX). The impact of a moderately increased PVR before HTX on post‐transplant outcomes remains uncer
Externí odkaz:
https://doaj.org/article/4c5f48484af14dfc967db3113f9da696
Autor:
Ann-Kathrin Rahm, Susanne Reinhardt, Matthias Helmschrott, Fabrice F. Darche, Tom Bruckner, Patrick Lugenbiel, Dierk Thomas, Philipp Ehlermann, Wiebke Sommer, Gregor Warnecke, Norbert Frey, Rasmus Rivinius
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 9, Iss 10, p 337 (2022)
Aims: Atrial flutter (AFL) is a common late-onset complication after heart transplantation (HTX) and is associated with worse clinical outcomes. Methods: This study investigated the frequency, risk factors, and outcomes of late-onset post-transplant
Externí odkaz:
https://doaj.org/article/30538143b0414c54a551f36da7773e1c