Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Matthias Hebrok"'
Autor:
Sapna Puri, Hasna Maachi, Gopika Nair, Holger A. Russ, Richard Chen, Pamela Pulimeno, Zachary Cutts, Vasilis Ntranos, Matthias Hebrok
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Despite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a transcriptional regulator of pancreas development, also func
Externí odkaz:
https://doaj.org/article/78e918df306c49569dad84919d98da27
Autor:
Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich, Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell–enriched hormones. Here, we examined how hormone misexpression was influence
Externí odkaz:
https://doaj.org/article/d8557c8689a94c42a21473f2861b2627
Autor:
Gauree S. Chendke, Bhushan N. Kharbikar, Sudipta Ashe, Gaetano Faleo, Julie B. Sneddon, Qizhi Tang, Matthias Hebrok, Tejal A. Desai
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 4, Pp n/a-n/a (2023)
Abstract Beta cell replacement therapy (BCRT) for patients with type 1 diabetes (T1D) improves blood glucose regulation by replenishing the endogenous beta cells destroyed by autoimmune attack. Several limitations, including immune isolation, prevent
Externí odkaz:
https://doaj.org/article/bdf451e523a94e80a96f8c5a8407ba68
Autor:
Eleonora de Klerk, Yini Xiao, Christopher H. Emfinger, Mark P. Keller, David I. Berrios, Valentina Loconte, Axel A. Ekman, Kate L. White, Rebecca L. Cardone, Richard G. Kibbey, Alan D. Attie, Matthias Hebrok
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Insulin secretion from pancreatic β cells is essential to the maintenance of glucose homeostasis. Defects in this process result in diabetes. Identifying genetic regulators that impair insulin secretion is crucial for the identification of novel the
Externí odkaz:
https://doaj.org/article/b4b5dbeb38934b90baccd9d13f8ca114
Autor:
Sandra Heller, Zhijian Li, Qiong Lin, Ryan Geusz, Markus Breunig, Meike Hohwieler, Xi Zhang, Gopika G. Nair, Thomas Seufferlein, Matthias Hebrok, Maike Sander, Cécile Julier, Alexander Kleger, Ivan G. Costa
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Heller et al analyze transcriptomic and epigenetic datasets from human PSCs differentiating into pancreatic progenitors to elucidate the regulatory mechanisms behind pancreatic development. The authors report that the transcription factor ONECUT1 is
Externí odkaz:
https://doaj.org/article/4622ff7d00c840df9df59d2628589a8c
Autor:
Christopher H. Emfinger, Eleonora de Klerk, Kathryn L. Schueler, Mary E. Rabaglia, Donnie S. Stapleton, Shane P. Simonett, Kelly A. Mitok, Ziyue Wang, Xinyue Liu, Joao A. Paulo, Qinq Yu, Rebecca L. Cardone, Hannah R. Foster, Sophie L. Lewandowski, José C. Perales, Christina M. Kendziorski, Steven P. Gygi, Richard G. Kibbey, Mark P. Keller, Matthias Hebrok, Matthew J. Merrins, Alan D. Attie
Publikováno v:
JCI Insight, Vol 7, Iss 10 (2022)
Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell–specific deletion of Zfp148 (β-Zfp148KO) improves glucose to
Externí odkaz:
https://doaj.org/article/89940b8a0be241239ae78674f9a31df7
Autor:
Ronan Russell, Phichitpol P. Carnese, Thomas G. Hennings, Emily M. Walker, Holger A. Russ, Jennifer S. Liu, Simone Giacometti, Roland Stein, Matthias Hebrok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MAF bZIP transcription factor B (MAFB) is present in postnatal human beta cells but its role is unclear. Here, the authors show that MAFB regulates endocrine pancreatic cell fate specification.
Externí odkaz:
https://doaj.org/article/e0d2c3d6cf86401bb280695fe609017c
Autor:
Xin Zhou, Gopika G. Nair, Holger A. Russ, Cassandra D. Belair, Mei-Lan Li, Mayya Shveygert, Matthias Hebrok, Robert Blelloch
Publikováno v:
Stem Cell Reports, Vol 14, Iss 1, Pp 9-20 (2020)
Summary: Differentiation of human embryonic stem cells into pancreatic β cells holds great promise for the treatment of diabetes. Recent advances have led to the production of glucose-responsive insulin-secreting cells in vitro, but resulting cells
Externí odkaz:
https://doaj.org/article/24b90ec89952421982da2c90744377f2
Autor:
Audrey M Hendley, Arjun A Rao, Laura Leonhardt, Sudipta Ashe, Jennifer A Smith, Simone Giacometti, Xianlu L Peng, Honglin Jiang, David I Berrios, Mathias Pawlak, Lucia Y Li, Jonghyun Lee, Eric A Collisson, Mark S Anderson, Gabriela K Fragiadakis, Jen Jen Yeh, Chun Jimmie Ye, Grace E Kim, Valerie M Weaver, Matthias Hebrok
Publikováno v:
eLife, Vol 10 (2021)
To study disease development, an inventory of an organ's cell types and understanding of physiologic function is paramount. Here, we performed single-cell RNA-sequencing to examine heterogeneity of murine pancreatic duct cells, pancreatobiliary cells
Externí odkaz:
https://doaj.org/article/62699ea62af1409c840ff2fb6ef43383
Autor:
Eleonora de Klerk, Matthias Hebrok
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Since its introduction more than twenty years ago, intraportal allogeneic cadaveric islet transplantation has been shown to be a promising therapy for patients with Type I Diabetes (T1D). Despite its positive outcome, the impact of islet transplantat
Externí odkaz:
https://doaj.org/article/1ee9108c0b8c481b8c09395954dfee5e