Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Matthias Hardtke‐Wolenski"'
Publikováno v:
Molecular and Cellular Pediatrics, Vol 11, Iss 1, Pp 1-18 (2024)
Abstract Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for maintaining immune homeostasis and preventing excessive immune responses. Depending on their differentiation route, Tregs can be subdivided into
Externí odkaz:
https://doaj.org/article/ad6440418b754cc3a2d8ea4ce5333355
Autor:
Nadja Seltrecht, Matthias Hardtke-Wolenski, Konstantinos Iordanidis, Danny Jonigk, Melanie Galla, Axel Schambach, Laura Elisa Buitrago-Molina, Heiner Wedemeyer, Fatih Noyan, Elmar Jaeckel
Publikováno v:
Cells, Vol 13, Iss 14, p 1216 (2024)
Background: Solid organ transplantation is hindered by immune-mediated chronic graft dysfunction and the side effects of immunosuppressive therapy. Regulatory T cells (Tregs) are crucial for modulating immune responses post-transplantation; however,
Externí odkaz:
https://doaj.org/article/4429a14562044937a921119004b57d0a
Autor:
Janine Dywicki, Laura Elisa Buitrago-Molina, Fatih Noyan, Jerome Schlue, Konstantinos Iordanidis, Michael P. Manns, Heiner Wedemeyer, Elmar Jaeckel, Matthias Hardtke-Wolenski
Publikováno v:
European Journal of Medical Research, Vol 27, Iss 1, Pp 1-8 (2022)
Abstract Autoimmune hepatitis (AIH) is a chronic immune-mediated inflammatory liver disease. It is known that AIH originates not from the spleen but from the liver itself. Nonetheless, most details of the etiology and pathophysiology are unknown. We
Externí odkaz:
https://doaj.org/article/b06c23f9432545069705c91450ad0e1a
Autor:
Janine Dywicki, Laura Elisa Buitrago‐Molina, Fatih Noyan, Ana C. Davalos‐Misslitz, Katharina L. Hupa‐Breier, Maren Lieber, Martin Hapke, Jerome Schlue, Christine S. Falk, Solaiman Raha, Immo Prinz, Christian Koenecke, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke‐Wolenski, Elmar Jaeckel
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 320-333 (2022)
Nonalcoholic steatohepatitis (NASH) is induced by steatosis and metabolic inflammation. While involvement of the innate immune response has been shown, the role of the adaptive immune response in NASH remains controversial. Likewise, the role of regu
Externí odkaz:
https://doaj.org/article/c74f2c70e32d41ff853767285a092092
Autor:
Valerie Saetzler, Tobias Riet, Andrea Schienke, Pierre Henschel, Kiara Freitag, Alexander Haake, Frank L. Heppner, Laura Elisa Buitrago-Molina, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Publikováno v:
Cells, Vol 12, Iss 16, p 2115 (2023)
Background: Alzheimer’s disease (AD) is a neurodegenerative disease that remains uncured. Its pathogenesis is characterized by the formation of β-amyloid (Aβ) plaques. The use of antigen-specific regulatory T cells (Tregs) through adoptive transf
Externí odkaz:
https://doaj.org/article/f72eecfb2b00440c95d4793a333c7460
Autor:
Jakob Kremer, Pierre Henschel, Daniel Simon, Tobias Riet, Christine Falk, Matthias Hardtke-Wolenski, Heiner Wedemeyer, Fatih Noyan, Elmar Jaeckel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundRegulatory T cells (Tregs) play an important role in the maintenance of immune homeostasis and the establishment of immune tolerance. Since Tregs do not secrete endogenous IL-2, they are especially dependent on external IL-2. IL-2 deficienc
Externí odkaz:
https://doaj.org/article/ea80f19ee0df4f12bf0f902ab7227976
Autor:
Sandra Bufe, Artur Zimmermann, Sarina Ravens, Immo Prinz, Laura Elisa Buitrago-Molina, Robert Geffers, Norman Woller, Florian Kühnel, Steven R. Talbot, Fatih Noyan, Michael Peter Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel, Ana C. Davalos-Misslitz
Publikováno v:
Liver Cancer (2022)
Background: Checkpoint inhibitors act on exhausted CD8+ T cells and restore their effector function in chronic infections and cancer. The underlying mechanisms of action appear to differ between different types of cancer and are not yet fully underst
Externí odkaz:
https://doaj.org/article/965c2a4212154815948f7cc4a347137a
Autor:
Tom Pieper, Kristian Daniel Ralph Roth, Viktor Glaser, Tobias Riet, Laura Elisa Buitrago-Molina, Maike Hagedorn, Maren Lieber, Michael Hust, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski
Publikováno v:
Cells, Vol 12, Iss 11, p 1453 (2023)
Adoptive transfer of antigen-specific regulatory T cells (Tregs) has shown promising results in the treatment of autoimmune diseases; however, the use of polyspecific Tregs has limited effects. However, obtaining a sufficient number of antigen-specif
Externí odkaz:
https://doaj.org/article/2290f40ad4254c9d8cd3659fc1a59533
Autor:
Laura Elisa Buitrago-Molina, Janine Dywicki, Fatih Noyan, Lena Schepergerdes, Julia Pietrek, Maren Lieber, Jerome Schlue, Michael P. Manns, Heiner Wedemeyer, Elmar Jaeckel, Matthias Hardtke-Wolenski
Publikováno v:
Cells, Vol 10, Iss 6, p 1471 (2021)
Background: Autoimmune hepatitis (AIH) is a chronic autoimmune inflammatory disease that usually requires lifelong immunosuppression. Frequent recurrences after the discontinuation of therapy indicate that intrahepatic immune regulation is not restor
Externí odkaz:
https://doaj.org/article/88cb606e6dfb4eec8cf7121b1307fd55
Autor:
Katharina Luise Hupa-Breier, Janine Dywicki, Björn Hartleben, Freya Wellhöner, Benjamin Heidrich, Richard Taubert, Young-Seon Elisabeth Mederacke, Maren Lieber, Konstantinos Iordanidis, Michael P. Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel
Publikováno v:
Biomedicines, Vol 9, Iss 4, p 353 (2021)
Dysregulation of glucose homeostasis plays a major role in the pathogenesis of non-alcoholic steatohepatitis (NASH) as it activates proinflammatory and profibrotic processes. Beneficial effects of antiglycemic treatments such as GLP-1 agonist or SGLT
Externí odkaz:
https://doaj.org/article/10ab30e20bf14c3cad4a1213c8ed0316