Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

Autor: Amanda Littlewood-Evans, Simona Cotesta, Philipp Janser, Rochdi Bouhelal, Rowan Stringer, Stephanie Harlfinger, Philippe Piechon, Rainer Wilcken, Matthias Haffke, Fabian Piller, Frederic Villard, Dominique Fehlmann, Trixie Wagner, Klemens Kaupmann, Achim Schlapbach, Nina Gommermann, Juraj Velcicky

Publikováno v: Journal of medicinal chemistry. 63(17)

G-protein-coupled receptor SUCNR1 (succinate receptor 1 or GPR91) senses the citric cycle intermediate succinate and is implicated in various pathological conditions such as rheumatoid arthritis, liver fibrosis, or obesity. Here, we describe a novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e04b8678f9f63ad66e38607af8c753
https://pubmed.ncbi.nlm.nih.gov/32856916

Membrane Protein Expression in Insect Cells Using the Baculovirus Expression Vector System

Autor: Veli-Pekka Jaakola, Jacques Boivineau, Matthias Haffke

Publikováno v: Methods in Molecular Biology ISBN: 9781071603727

Integral membrane proteins have a critical role in fundamental biological processes; they are major drug targets and therefore of high research interest. Recombinant protein production is the first step in the protein tool generation for biochemical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9a1c5aa01568402f975dc36032557bf
https://doi.org/10.1007/978-1-0716-0373-4_5

Development of a biochemical and biophysical suite for integral membrane protein targets: A review

Autor: Veli-Pekka Jaakola, Binesh Shrestha, Myriam Duckely, Christian Bergsdorf, Matthias Haffke

Publikováno v: Protein Expression and Purification. 167:105545

The generation of integral membrane proteins (IMPs) in heterologous systems and their characterization remains a major challenge in biomedical research. Significant efforts have been invested both in academia and in the pharmaceutical industry to est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907677a257ea9130c74cc22686d25172
https://doi.org/10.1016/j.pep.2019.105545

ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts

Autor: Yan, Nie, Maxime, Chaillet, Christian, Becke, Matthias, Haffke, Martin, Pelosse, Daniel, Fitzgerald, Ian, Collinson, Christiane, Schaffitzel, Imre, Berger

Publikováno v: Advances in experimental medicine and biology. 896

Multicomponent biological systems perform a wide variety of functions and are crucially important for a broad range of critical health and disease states. A multitude of applications in contemporary molecular and synthetic biology rely on efficient,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6a8ce0a5e18f8795e4239e7721bd8c9
https://pubmed.ncbi.nlm.nih.gov/27165317

Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules

Autor: Elisabeth Scheer, Marjorie Fournier, Juan Zou, Laszlo Tora, Gabor Papai, Cristina Viola, Imre Berger, Virginie Chavant, Ima-Obong Ebong, Matthias Haffke, Juri Rappsilber, Patrick Schultz, Carol V. Robinson, Simon Trowitzsch, Sascha Conic, Christiane Schaffitzel

Publikováno v: Trowitzsch, S, Viola, C, Scheer, E, Conic, S, Chavant, V, Fournier, M, Papai, G, Ebong, I-O, Schaffitzel, C, Zou, J, Haffke, M, Rappsilber, J, Robinson, C V, Schultz, P, Tora, L & Berger, I 2015, ' Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules ', Nature Communications, vol. 6, 6011 . https://doi.org/10.1038/ncomms7011
Nature Communications
Nature Communications, 2015, 6 (1), ⟨10.1038/ncomms7011⟩
Trowitzsch, S, Viola, C, Scheer, E, Conic, S, Chavant, V, Fournier, M, Papai, G, Ebong, I O, Schaffitzel, C, Zou, J, Haffke, M, Rappsilber, J, Robinson, C V, Schultz, P, Tora, L & Berger, I 2015, ' Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules ', Nature Communications, vol. 6, 6011 . https://doi.org/10.1038/ncomms7011
Nature Communications, Nature Publishing Group, 2015, 6 (1), ⟨10.1038/ncomms7011⟩
'Nature Communications ', vol: 6, pages: 6011-1-6011-14 (2015)

General transcription factor TFIID is a cornerstone of RNA polymerase II transcription initiation in eukaryotic cells. How human TFIID—a megadalton-sized multiprotein complex composed of the TATA-binding protein (TBP) and 13 TBP-associated factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c6d80c55b2f34cffa4bd4f7657bd49
https://research-information.bris.ac.uk/en/publications/e9745711-8894-4dce-91a5-a750b4d7dbf7