Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Matthias H Tschöp"'
Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease
Autor:
Lili Niu, Philipp E Geyer, Nicolai J Wewer Albrechtsen, Lise L Gluud, Alberto Santos, Sophia Doll, Peter V Treit, Jens J Holst, Filip K Knop, Tina Vilsbøll, Anders Junker, Stephan Sachs, Kerstin Stemmer, Timo D Müller, Matthias H Tschöp, Susanna M Hofmann, Matthias Mann
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 3, Pp 1-16 (2019)
Abstract Non‐alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes most of the blood plasma proteins, liver disease may affect the plasma proteome. Pl
Externí odkaz:
https://doaj.org/article/68d1f8e06d6e4c258b2e165f6952476b
Autor:
Christoffer Clemmensen, Brian Finan, Katrin Fischer, Robby Zachariah Tom, Beata Legutko, Laura Sehrer, Daniela Heine, Niklas Grassl, Carola W Meyer, Bart Henderson, Susanna M Hofmann, Matthias H Tschöp, Lex HT Van der Ploeg, Timo D Müller
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 3, Pp 288-298 (2015)
Abstract We assessed the efficacy of simultaneous agonism at the glucagon‐like peptide‐1 receptor (GLP‐1R) and the melanocortin‐4 receptor (MC4R) for the treatment of obesity and diabetes in rodents. Diet‐induced obese (DIO) mice were chron
Externí odkaz:
https://doaj.org/article/c1558d4a607f4a25a4ebf5a0ff08660d
Autor:
Carolin Piotrowski, Vera Lede, Anne Butthof, Nicole Kaiser, Petra G Hirrlinger, Matthias H Tschöp, Torsten Schöneberg, Ingo Bechmann
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187192 (2017)
Nasal mucosa and olfactory bulb are separated by the cribriform plate which is perforated by olfactory nerves. We have previously demonstrated that the cribriform plate is permissive for T cells and monocytes and that viruses can enter the bulb upon
Externí odkaz:
https://doaj.org/article/e1f7510872204f319045f72002dfea75
Autor:
Katrin Pfuhlmann, Paul T Pfluger, Sonja C Schriever, Timo D Müller, Matthias H Tschöp, Kerstin Stemmer
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183488 (2017)
Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase (ERK), for the regulation of body weight and glucose homeostasis. We further assessed wheth
Externí odkaz:
https://doaj.org/article/13149f41a6904a828fd3c7041c04bfdc
Publikováno v:
eLife, Vol 3 (2014)
The response of the brain to sugar is determined by specific cell populations in the brain, including neurons that secrete melanin-concentrating hormone, and culminates in the release of dopamine.
Externí odkaz:
https://doaj.org/article/95e86496872b4836a8707c2dbfc89d34
Autor:
Henriette Kirchner, Kristy M Heppner, Jenna Holland, Dhiraj Kabra, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61822 (2013)
Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin
Externí odkaz:
https://doaj.org/article/44b210890d6d43568d7899a3aa907c59
Autor:
Huan Cai, Wei-Na Cong, Caitlin M Daimon, Rui Wang, Matthias H Tschöp, Jean Sévigny, Bronwen Martin, Stuart Maudsley
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76553 (2013)
Taste perception plays an important role in regulating food preference, eating behavior and energy homeostasis. Taste perception is modulated by a variety of factors, including gastric hormones such as ghrelin. Ghrelin can regulate growth hormone rel
Externí odkaz:
https://doaj.org/article/0e9dfd64e08b42af9518de425a2c6302
Publikováno v:
PLoS Genetics, Vol 9, Iss 1, p e1003223 (2013)
Externí odkaz:
https://doaj.org/article/573a7ff5d7d9460db566b8e0a9573e42
Autor:
Tamara R Castañeda, William Abplanalp, Sung Hee Um, Paul T Pfluger, Brigitte Schrott, Kimberly Brown, Erin Grant, Larissa Carnevalli, Stephen C Benoit, Donald A Morgan, Dean Gilham, David Y Hui, Kamal Rahmouni, George Thomas, Sara C Kozma, Deborah J Clegg, Matthias H Tschöp
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32631 (2012)
Targeted deletion of S6 kinase (S6K) 1 in mice leads to higher energy expenditure and improved glucose metabolism. However, the molecular mechanisms controlling these effects remain to be fully elucidated. Here, we analyze the potential role of dieta
Externí odkaz:
https://doaj.org/article/7da010e228ee4cde9cfbd8ad394306a7
Autor:
Matthias J Betz, Maximilian Bielohuby, Brigitte Mauracher, William Abplanalp, Hans-Helge Müller, Korbinian Pieper, Juliane Ramisch, Matthias H Tschöp, Felix Beuschlein, Martin Bidlingmaier, Marc Slawik
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38997 (2012)
UNLABELLED: Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight lo
Externí odkaz:
https://doaj.org/article/60b483482457458b9c5b5b8f1aa4d73b