Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Matthias Gotte"'
Publikováno v:
New Drug Development for Known and Emerging Viruses. :97-132
Autor:
Calvin J. Gordon, Hery W. Lee, Egor P. Tchesnokov, Jason K. Perry, Joy Y. Feng, John P. Bilello, Danielle P. Porter, Matthias Gotte
Publikováno v:
The FASEB Journal. 36
Autor:
François Lamontagne, Arnav Agarwal, Bram Rochwerg, Reed AC Siemieniuk, Thomas Agoritsas, Lisa Askie, Lyubov Lytvyn, Yee-Sin Leo, Helen Macdonald, Linan Zeng, Wagdy Amin, André Ricardo Araujo da Silva, Diptesh Aryal, Fabian A Jaimes Barragan, Frederique J Bausch, Erlina Burhan, Carolyn S Calfee, Maurizio Cecconi, Binila Chacko, Duncan Chanda, Vu Quoc Dat, An De Sutter, Bin Du, Stephen Freedman, Heike Geduld, Patrick Gee, Matthias Gotte, Nerina Harley, Madiha Hashmi, Beverley Hunt, Fyezah Jehan, Sushil K Kabra, Seema Kanda, Yae-Jean Kim, Niranjan Kissoon, Sanjeev Krishna, Krutika Kuppalli, Arthur Kwizera, Marta Lado Castro-Rial, Thiago Lisboa, Rakesh Lodha, Imelda Mahaka, Hela Manai, Marc Mendelson, Giovanni Battista Migliori, Greta Mino, Emmanuel Nsutebu, Jacobus Preller, Natalia Pshenichnaya, Nida Qadir, Pryanka Relan, Saniya Sabzwari, Rohit Sarin, Manu Shankar-Hari, Michael Sharland, Yinzhong Shen, Shalini S Ranganathan, Joao P Souza, Miriam Stegemann, Ronald Swanstrom, Sebastian Ugarte, Tim Uyeki, Sridhar Venkatapuram, Dubula Vuyiseka, Ananda Wijewickrama, Lien Tran, Dena Zeraatkar, Jessica J Bartoszko, Long Ge, Romina Brignardello-Petersen, Andrew Owen, Gordon Guyatt, Janet Diaz, Leticia Kawano-Dourado, Michael Jacobs, Per Olav Vandvik
Publikováno v:
BMJ (Clinical Research Edition), Vol. 370 (2020) P. m3379
BMJ
BMJ
This is the twelfth version (eleventh update) of the living guideline, replacing earlier versions (available as data supplements). New recommendations will be published as updates to this guideline.What is the role of drugs in the treatment of patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed70446a684b1f4ccc31a1f90edaf73
https://ora.ox.ac.uk/objects/uuid:630dd5a2-9584-4bb6-83a4-33564d1fa5d9
https://ora.ox.ac.uk/objects/uuid:630dd5a2-9584-4bb6-83a4-33564d1fa5d9
Autor:
Samer Girgis, Zaikun Xu, Spyros Oikonomopoulos, Alla D. Fedorova, Egor P. Tchesnokov, Calvin J. Gordon, T. Martin Schmeing, Matthias Götte, Nahum Sonenberg, Pavel V. Baranov, Jiannis Ragoussis, Tom C. Hobman, Jerry Pelletier
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Genomes from defective interfering (DI) particles following serial passaging of SARS-CoV-2 reveal a fusion protein that attenuates viral replication. Synthetic, recombinant DI genomes are designed to interfere with SARS-CoV-2 replication.
Externí odkaz:
https://doaj.org/article/5e493b54c37c47c3a8ea41d5c87f53e3
Autor:
Stuart LeGrice, Matthias Gotte
The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the f
Autor:
George J. Klarmann, Stuart F. J. Le Grice, Sidney M. Hecht, Janice D. Pata, Yi Zhang, Matthias Gotte, Deb K. Chatterjee, Brian M. Eisenhauer
Publikováno v:
Biochemistry. 46(8)
To investigate how structural changes in the amino acid side chain affect nucleotide substrate selection in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), a variety of non-natural tyrosine analogues were substituted for Tyr11
Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our parti
Autor:
Kayley D. McCubbin, R. Michele Anholt, Ellen de Jong, Jennifer A. Ida, Diego B. Nóbrega, John P. Kastelic, John M. Conly, Matthias Götte, Tim A. McAllister, Karin Orsel, Ian Lewis, Leland Jackson, Graham Plastow, Hans-Joachim Wieden, Kathy McCoy, Myles Leslie, Joan L. Robinson, Lorian Hardcastle, Aidan Hollis, Nicholas J. Ashbolt, Sylvia Checkley, Gregory J. Tyrrell, André G. Buret, Elissa Rennert-May, Ellen Goddard, Simon J. G. Otto, Herman W. Barkema
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Current limitations in the understanding and control of antimicrobial resistance (AMR) in Canada are described through a comprehensive review focusing on: (1) treatment optimization; (2) surveillance of antimicrobial use and AMR; and (3) prevention o
Externí odkaz:
https://doaj.org/article/af0334612919462f9363cb6a18f8d23f
Autor:
Joy Y. Feng, Venice Du Pont, Darius Babusis, Calvin J. Gordon, Egor P. Tchesnokov, Jason K. Perry, Vincent Duong, Arya Vijjapurapu, Xiaofeng Zhao, Julie Chan, Cal Cohen, Kavita Juneja, Tomas Cihlar, Matthias Götte, John P. Bilello
Publikováno v:
Molecules, Vol 27, Iss 13, p 4212 (2022)
The urgent response to the COVID-19 pandemic required accelerated evaluation of many approved drugs as potential antiviral agents against the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using cell-based, biochemi
Externí odkaz:
https://doaj.org/article/8efa8d1cc25f4a15b4af0c4caa0f1353
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008283 (2020)
BACKGROUND:The Crimean-Congo hemorrhagic fever virus (CCHFV) is a segmented negative-sense RNA virus that can cause severe human disease. The World Health Organization (WHO) has listed CCHFVas a priority pathogen with an urgent need for enhanced rese
Externí odkaz:
https://doaj.org/article/59d032dbc526464a897039adead39963