Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Matthias Gehringer"'
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 206 (2024)
Covalent inhibitors have experienced a revival in medicinal chemistry and chemical biology in recent decades [...]
Externí odkaz:
https://doaj.org/article/7140dcbb3d064635b972e1b4426865cd
Autor:
Laura Hillebrand, Matthias Gehringer
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
Covalent inhibitors have recently seen a revival in medicinal chemistry. Inhibitors addressing non-catalytic cysteine residues with weakly reactive electrophiles have been very successfully employed to target protein kinases, one of the major druggab
Externí odkaz:
https://doaj.org/article/4c84a2c9d3e549978e4e0c112c01cf58
Autor:
Valentin Wydra, Stefan Gerstenecker, Dieter Schollmeyer, Stanislav Andreev, Teodor Dimitrov, Ricardo Augusto Massarico Serafim, Stefan Laufer, Matthias Gehringer
Publikováno v:
Molbank, Vol 2021, Iss 1, p M1181 (2021)
Here we describe the synthesis of N-(6-chloro-3-nitropyridin-2-yl)5-(1-methyl-1H-pyrazol-4-yl)isoquinolin-3-amine via a three-step procedure including a Buchwald–Hartwig arylamination with benzophenone imine and a highly regioselective nucleophilic
Externí odkaz:
https://doaj.org/article/34bf14f260074d1bafe06b47476f421b
Autor:
Louisa Warryn, Jean-Pierre Dangy, Philipp Gersbach, Matthias Gehringer, Anja Schäfer, Marie-Thérèse Ruf, Nicolas Ruggli, Karl-Heinz Altmann, Gerd Pluschke
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008357 (2020)
Mycolactones, macrolide cytotoxins, are key virulence factors of Mycobacterium ulcerans, the etiological agent of the chronic necrotizing skin disease Buruli ulcer. There is urgent need for a simple point-of-care laboratory test for Buruli ulcer and
Externí odkaz:
https://doaj.org/article/deaf562998254bd3ae3722701aa7df5e
Autor:
Matthias Gehringer, Karl-Heinz Altmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 1596-1660 (2017)
Mycolactones are a group of macrolides excreted by the human pathogen Mycobacterium ulcerans, which exhibit cytotoxic, immunosuppressive and analgesic properties. As the virulence factor of M. ulcerans, mycolactones are central to the pathogenesis of
Externí odkaz:
https://doaj.org/article/4ea2205718c24001a911333ec34d2f80
Autor:
Matthias Gehringer, Ellen Pfaffenrot, Peter R. W. E. F. Keck, Dieter Schollmeyer, Stefan A. Laufer
Publikováno v:
Acta Crystallographica Section E, Vol 70, Iss 4, Pp o382-o383 (2014)
In the title compound, C18H24N6O·H2O, the piperidine ring adopts a chair conformation with an N—C—C—C torsion angle of 39.5 (5)° between the cis-related substituents. The pyrrole N—H group forms a water-mediated intermolecular hydrogen bond
Externí odkaz:
https://doaj.org/article/f4b4cb518f6e4b28ab9acd05de58c32b
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 6, Pp o935-o935 (2013)
The piperidine ring of the title compound, C15H25N3O3, adopts a slightly distorted chair conformation with the cis substituents displaying an N—C—C—C torsion angle of 43.0 (3)°. The cyano group (plane defined by C—C—C[triple-bond]N atoms)
Externí odkaz:
https://doaj.org/article/7f367b2eac504e3db6028aada905b8f8
Autor:
Ricardo A. M. Serafim, André da Silva Santiago, Martin P. Schwalm, Zexi Hu, Caio V. dos Reis, Jessica E. Takarada, Priscila Mezzomo, Katlin B. Massirer, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Lars Zender, Stefan Knapp, Stefan Laufer, Rafael M. Couñago, Matthias Gehringer
Publikováno v:
Journal of Medicinal Chemistry. 65:3173-3192
Monopolar spindle kinase 1 (MPS1/TTK) is a key element of the mitotic checkpoint and clinically evaluated as a target in the treatment of aggressive tumors such as triple-negative breast cancer. While long drug-target residence times have been sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f487f2c8d895ec56739c4e762882757
https://doi.org/10.1021/acs.jmedchem.1c01165
https://doi.org/10.1021/acs.jmedchem.1c01165
Autor:
Eleonora Diamanti, María Méndez, Tatjana Ross, Christian A. Kuttruff, Julien Lefranc, Franca‐Maria Klingler, Franz von Nussbaum, Manfred Jung, Matthias Gehringer
Publikováno v:
ChemMedChem. 17
The Frontiers in Medicinal Chemistry (FiMC) meeting, which represents the largest international medicinal chemistry conference in Germany, took place from March 14supth/supto 16supth/sup2022 in a fully virtual format. Organized by the Division of Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97820a95bbbafb3ee93891b3d7904bd0
https://doi.org/10.1002/cmdc.202200419
https://doi.org/10.1002/cmdc.202200419
Autor:
Louisa Warryn, Karl-Heinz Altmann, Philipp Gersbach, Gerd Pluschke, Matthias Gehringer, Jean-Pierre Dangy
Publikováno v:
J Immunol
Mycolactone is a cytotoxin responsible for most of the chronic necrotizing pathology of Mycobacterium ulcerans disease (Buruli ulcer). The polyketide toxin consists of a 12-membered lactone ring with a lower O-linked polyunsaturated acyl side chain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a4c5ea4977da73df0d0848a312ba7d
https://doi.org/10.4049/jimmunol.2001232
https://doi.org/10.4049/jimmunol.2001232