Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Matthias Göhl"'
Autor:
Matthias Göhl, Linlin Zhang, Haifa El Kilani, Xinyuanyuan Sun, Kaixuan Zhang, Mark Brönstrup, Rolf Hilgenfeld
Publikováno v:
Molecules, Vol 27, Iss 13, p 4292 (2022)
The main protease (Mpro) of the betacoronavirus SARS-CoV-2 is an attractive target for the development of treatments for COVID-19. Structure-based design is a successful approach to discovering new inhibitors of the Mpro. Starting from crystal struct
Externí odkaz:
https://doaj.org/article/488aaa69ec3940b1a6c55eaca08c0fae
Publikováno v:
European Journal of Forest Research.
In south-east Norway, in the hemiboreal vegetation zone, the beech reaches its northern distribution limit and typically occupy the same type of sites as spruce. Under future climate change, this area is projected to fall within the temperate zone an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc6160ac348428e8501cfcfcaa1002b
https://doi.org/10.1007/s10342-023-01576-7
https://doi.org/10.1007/s10342-023-01576-7
Publikováno v:
Journal of the American Chemical Society, vol 145, iss 11
The evolution of a successful strategy for the synthesis of the strained, cage-like antiviral diterpenoids wickerols A and B is described. Initial attempts to access the carbocyclic core were surprisingly challenging and in retrospect, presaged the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e777708248decb0aff6f76997f6a4cb
https://escholarship.org/uc/item/6kf2m060
https://escholarship.org/uc/item/6kf2m060
Autor:
Mark S. Cooper, Linlin Zhang, Mohamed Ibrahim, Kaixuan Zhang, Xinyuanyuan Sun, Judith Röske, Matthias Göhl, Mark Brönstrup, Justin K. Cowell, Lucie Sauerhering, Stephan Becker, Laura Vangeel, Dirk Jochmans, Johan Neyts, Katharina Rox, Graham P. Marsh, Hannah J. Maple, Rolf Hilgenfeld
Publikováno v:
Journal of medicinal chemistry. 65(19)
SARS-CoV-2 is the causative agent behind the COVID-19 pandemic. The main protease (Mpro, 3CLpro) of SARS-CoV-2 is a key enzyme that processes polyproteins translated from the viral RNA. Mpro is therefore an attractive target for the design of inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b74f07e5edbbb44abd89a69a4e8a45
https://pubmed.ncbi.nlm.nih.gov/36179320
https://pubmed.ncbi.nlm.nih.gov/36179320
Publikováno v:
Org Lett
Organic letters, vol 21, iss 19
Organic letters, vol 21, iss 19
New chemical probes have been designed to facilitate the identification of adenosine-to-inosine (A-to-I) edited RNAs. These reagents combine a conjugate acceptor for selective inosine covalent modification with functional groups for bioorthogonal bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc3aa303a41244f0a0768820d4697e0
https://europepmc.org/articles/PMC7308179/
https://europepmc.org/articles/PMC7308179/
Autor:
Andreas Jürgens, Steven D. Johnson, Stefan Dötterl, Michael von Tschirnhaus, Ulrich Meve, Matthias Göhl, Annemarie Heiduk, Irina Brake
Publikováno v:
Current Biology. 26:2787-2793
Four to six percent of plants, distributed over different angiosperm families, entice pollinators by deception [1]. In these systems, chemical mimicry is often used as an efficient way to exploit the olfactory preferences of animals for the purpose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef8f8f063e0fac4eae578072210138c0
https://doi.org/10.1016/j.cub.2016.07.085
https://doi.org/10.1016/j.cub.2016.07.085
Publikováno v:
Chemistry & Biodiversity. 12:1746-1755
The two new indole alkaloids 2-amino-1,5-dihydro-5-(1H-indol-3-ylmethyl)-4H-imidazol-4-one (1), 2-amino-5-[(6-bromo-1H-indol-3-yl)methyl]-3,5-dihydro-3-methyl-4H-imidazol-4-one (2), and auramine (3) have been isolated from the sea anemone Heteractis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2660d0be6f2eb8c73c89c542c3e5e68
https://doi.org/10.1002/cbdv.201400406
https://doi.org/10.1002/cbdv.201400406
Autor:
Karlheinz Seifert, Konrad Dettner, Andreas Schierling, Jürgen Schmidt, Isabel Wittmann, Matthias Göhl
Publikováno v:
Chemistry & Biodiversity. 12:1422-1434
Rove beetles of the genus Stenus produce and store bioactive alkaloids like stenusine (3), 3-(2-methylbut-1-enyl)pyridine (4), and cicindeloine (5) in their pygidial glands to protect themselves from predation and microorganismic infestation. The bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d867f108253cc4f65af31fd1c3e0b3
https://doi.org/10.1002/cbdv.201400391
https://doi.org/10.1002/cbdv.201400391
Autor:
Matthias Göhl, Karlheinz Seifert
Publikováno v:
European Journal of Organic Chemistry. 2015:6249-6258
The first asymmetric synthesis of the sesquiterpene quinones 3-oxo- and 3β-hydroxytauranin (1, 2) was achieved and the originally proposed structure of 3α-hydroxytauranin was revised. The protected benzyl chloride 5 was obtained in six steps starti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a78bb8e84ce1265ee75bde94cd29b7b2
https://doi.org/10.1002/ejoc.201500815
https://doi.org/10.1002/ejoc.201500815
Publikováno v:
Drug Research. 65:500-504
Metabolism studies with selected test substances have shown that a model on the basis of the incubated hen's egg is suitable as a supplement to animal experimentation. Because of its 3,4-dimethoxyphenyl structure veratric acid (3,4-dimethoxybenzoic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd5921b40dcb0f90fbec2d3638765b4
https://doi.org/10.1055/s-0034-1390457
https://doi.org/10.1055/s-0034-1390457