Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Matthias G, von Herrath"'
Autor:
Teresa Rodriguez-Calvo, Gustaf Christoffersson, Christine Bender, Matthias G. von Herrath, Roberto Mallone, Sally C. Kent, Eddie A. James
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evid
Externí odkaz:
https://doaj.org/article/8ebd83c47ba24d9f92464ec043f3b06e
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
Since the establishment of the network for pancreatic organ donors with diabetes (nPOD), we have gained unprecedented insight into the pathology of human type 1 diabetes. Many of the pre-existing “dogmas”, mostly derived from studies of animal mo
Externí odkaz:
https://doaj.org/article/0babfa0cc6494912963122321b27a014
Autor:
Johnny Ludvigsson, Matthias G. von Herrath, Roberto Mallone, Karsten Buschard, Corrado Cilio, Maria Craig, Jorma Ilonen, David Leslie, Julie E. M. McGeoch, Darius Schneider, Jay S. Skyler, Malin Flodström Tullberg, Didier Hober
Publikováno v:
Frontiers in Public Health, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/4dc972887a924ff5bfba1ffac74e0615
Autor:
Marcela Brissova, Rachana Haliyur, Diane Saunders, Shristi Shrestha, Chunhua Dai, David M. Blodgett, Rita Bottino, Martha Campbell-Thompson, Radhika Aramandla, Gregory Poffenberger, Jill Lindner, Fong Cheng Pan, Matthias G. von Herrath, Dale L. Greiner, Leonard D. Shultz, May Sanyoura, Louis H. Philipson, Mark Atkinson, David M. Harlan, Shawn E. Levy, Nripesh Prasad, Roland Stein, Alvin C. Powers
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2667-2676 (2018)
Summary: Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon response to hypoglycemia following T1D diagnosis. The features of these residual
Externí odkaz:
https://doaj.org/article/179fb49bdb1e47cd9d5843dc1eb65012
Autor:
Julia Sbierski-Kind, Jonas Kath, Sebastian Brachs, Mathias Streitz, Matthias G. von Herrath, Anja A. Kühl, Katharina Schmidt-Bleek, Knut Mai, Joachim Spranger, Hans-Dieter Volk
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Obesity is associated with adipose tissue inflammation, insulin resistance, and the development of type 2 diabetes (T2D). However, our knowledge is mostly based on conventional murine models and promising preclinical studies rarely translated into su
Externí odkaz:
https://doaj.org/article/ec65ee0a6c594a3daae3a9fbe1934be3
Autor:
Burcak Yesildag, Joan Mir-Coll, Aparna Neelakandhan, Claire B. Gibson, Nikole R. Perdue, Chantal Rufer, Maria Karsai, Adelinn Biernath, Felix Forschler, Patricia Wu Jin, Patrick M. Misun, Alexandra Title, Andreas Hierlemann, Frederik F. Kreiner, Johnna D. Wesley, Matthias G. von Herrath
Publikováno v:
Clinical immunology (Orlando, Fla.). 244
To enable accurate, high-throughput and longer-term studies of the immunopathogenesis of type 1 diabetes (T1D), we established three in-vitro islet-immune injury models by culturing spheroids derived from primary human islets with proinflammatory cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561404b070faf8677ab2fb48aa83c857
https://pubmed.ncbi.nlm.nih.gov/36084852
https://pubmed.ncbi.nlm.nih.gov/36084852
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Cytotoxic T lymphocytes execute the killing of insulin-producing beta cells during onset of type 1 diabetes mellitus (T1D). The research community has come far in dissecting the major events in the development of this disease, but still the trigger a
Externí odkaz:
https://doaj.org/article/8904103912e0430a840805781746a24c
Publikováno v:
Frontiers in Immunology, Vol 6 (2016)
Regulatory T cells (Tregs) play an important role in preventing effector T-cell (Teff) targeting of self-antigens that can lead to tissue destruction in autoimmune settings, including type 1 diabetes (T1D). Autoimmunity is caused in part by an imbala
Externí odkaz:
https://doaj.org/article/79bdde00fd5a467399b5a169e0861fd2
Publikováno v:
Clinical and Developmental Immunology, Vol 13, Iss 1, Pp 67-77 (2006)
Externí odkaz:
https://doaj.org/article/7cb64da4e10e42dbb2b429c32881a21a
Autor:
Thomas F. Dejgaard, Frederik Flindt Kreiner, Lars Bardtrum, Sten Madsbad, Bernt Johan von Scholten, Chantal Mathieu, Matthias G. Von Herrath, Erik Christiansen
Publikováno v:
Diabetes. 70
We re-evaluated the efficacy and safety of liraglutide, a GLP-1 analog, for use as adjunctive therapy in people with type 1 diabetes (T1D). Results from the two ADJUNCT trials suggested that residual beta-cell function is associated with more pronoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b487bbfb58c8a87431c9efcd9aa80a5
https://doi.org/10.2337/db21-675-p
https://doi.org/10.2337/db21-675-p