Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Matthias Elgeti"'
Autor:
Julia Belyaeva, Matthias Elgeti
Publikováno v:
eLife, Vol 13 (2024)
Under physiological conditions, proteins continuously undergo structural fluctuations on different timescales. Some conformations are only sparsely populated, but still play a key role in protein function. Thus, meaningful structure–function framew
Externí odkaz:
https://doaj.org/article/9623c925c1fd429ca482a22af26c5386
Autor:
Farha Khan, Matthias Elgeti, Samuel Grandfield, Aviv Paz, Fiona B. Naughton, Frank V. Marcoline, Thorsten Althoff, Natalia Ermolova, Ernest M. Wright, Wayne L. Hubbell, Michael Grabe, Jeff Abramson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Sodium-dependent glucose transporters (SGLTs) couple a downhill Na+ ion gradient to actively transport sugars. Here, we investigate the impact of the membrane potential on vSGLT structure and function using sugar uptake assays, double electr
Externí odkaz:
https://doaj.org/article/14990935ce0547d8bbd11e73b798bc03
Autor:
Simon Hellwig, Ulrike Grittner, Matthias Elgeti, Sebastian Wyschkon, Sebastian N. Nagel, Jochen B. Fiebach, Thomas Krause, Juliane Herm, Jan F. Scheitz, Matthias Endres, Christian H. Nolte, Karl Georg Haeusler, Thomas Elgeti
Publikováno v:
ESC Heart Failure, Vol 7, Iss 5, Pp 2572-2580 (2020)
Abstract Aims Heart failure (HF) is frequent in patients with acute ischaemic stroke (AIS) and associated with higher morbidity and mortality. Assessment of cardiac function in AIS patients using cardiovascular MRI (CMR) may help to detect HF. We rep
Externí odkaz:
https://doaj.org/article/9a35b66f39eb4874a74fe701b8519461
Autor:
Matthias Elgeti, Wayne L. Hubbell
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 778 (2021)
G protein-coupled receptors (GPCRs) represent a large class of transmembrane helical proteins which are involved in numerous physiological signaling pathways and therefore represent crucial pharmacological targets. GPCR function and the action of the
Externí odkaz:
https://doaj.org/article/991163fe50b14ef7b1f532410bbca46e
Autor:
Jiawei Zhao, Matthias Elgeti, Evan S. O’Brien, Cecília P. Sár, Amal EI Daibani, Jie Heng, Xiaoou Sun, Tao Che, Wayne L. Hubbell, Brian K. Kobilka, Chunlai Chen
The μ-opioid receptor (μOR) is an important target for pain management and the molecular understanding of drug action will facilitate the development of better therapeutics. Here we show, using double electron-electron resonance (DEER) and single-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f00435d56f60300b4684a15212673970
https://doi.org/10.1101/2023.04.28.538657
https://doi.org/10.1101/2023.04.28.538657
Autor:
Wayne L. Hubbell, Andrew C. Kruse, Robert J. Lefkowitz, Conor McMahon, Howard A. Rockman, Matthias Elgeti, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Dean P. Staus
Publikováno v:
Proc Natl Acad Sci U S A
There is considerable interest in developing antibodies as functional modulators of G protein-coupled receptor (GPCR) signaling for both therapeutic and research applications. However, there are few antibody ligands targeting GPCRs outside of the che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b35f906b7b9631e5554ad558505ea4
https://doi.org/10.1073/pnas.2009029117
https://doi.org/10.1073/pnas.2009029117
Autor:
Rachel A. Matt, Daniel Hilger, Michael T. Lerch, Wayne L. Hubbell, Brian K. Kobilka, Matthieu Masureel, Matthias Elgeti, Kaavya Krishna Kumar, Bryon Foys
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 50
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 50
The β(2) adrenergic receptor (β(2)AR) is an archetypal G protein coupled receptor (GPCR). One structural signature of GPCR activation is a large-scale movement (ca. 6 to 14 Å) of transmembrane helix 6 (TM6) to a conformation which binds and activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a637c454c11c427136437ad06c8bd4
https://europepmc.org/articles/PMC7749303/
https://europepmc.org/articles/PMC7749303/
Autor:
Thomas Elgeti, Matthias Elgeti, Sebastian N. Nagel, Lars-Arne Schaafs, Fabian Knebel, Bernd Hamm, Ingo G. Steffen, Marcus R. Makowski, Sebastian Wyschkon
Publikováno v:
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 192(8)
To evaluate the diagnostic performance of diastolic function parameters derived from long-axis (LAX) planimetry compared with short-axis (SAX) volumetry in cardiac magnetic resonance imaging. Cine steady-state free precession (SSFP) datasets of 15 he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94a9b26c0c58ce7de8041b3a16c2457
https://pubmed.ncbi.nlm.nih.gov/32106325
https://pubmed.ncbi.nlm.nih.gov/32106325
Autor:
Yann Dacquay, Joseph R. Lee, Andrea Govetto, Matthias Elgeti, Wayne L Hubbell, Pirouz Kavehpour, Jean-Pierre Hubschman
Publikováno v:
Modeling and Artificial Intelligence in Ophthalmology. 2:71-80
Purpose: To evaluate whether perfluorocarbon (PFO) liquids can exacerbate condensation on intraocular lenses (IOL).Methods: Two separate experiments were carried out. In the first experiment, a two-segment chamber was constructed out of glass and acr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::059ede68d3eb2d3a14de823890ecbbd4
https://doi.org/10.35119/maio.v2i1.84
https://doi.org/10.35119/maio.v2i1.84
Autor:
Roman Kazmin, Peter W. Hildebrand, Michal Szczepek, Patrick Scheerer, Alexander S. Rose, Franz Bartl, Klaus Peter Hofmann, Matthias Elgeti
Publikováno v:
Journal of Biological Chemistry. 293:4403-4410
Signaling of the prototypical G protein–coupled receptor (GPCR) rhodopsin through its cognate G protein transducin (G(t)) is quenched when arrestin binds to the activated receptor. Although the overall architecture of the rhodopsin/arrestin complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d70364ae4f5ee74bbb3fe77db1cf72e
https://doi.org/10.1074/jbc.m117.817890
https://doi.org/10.1074/jbc.m117.817890