Výsledky vyhledávání - "Matthias Ebbinghaus"

Akademický článek

Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord

Autor: Anutosh Roy, Gisela Segond von Banchet, Fátima Gimeno-Ferrer, Christian König, Annett Eitner, Andrea Ebersberger, Matthias Ebbinghaus, Johannes Leuchtweis, Hans-Georg Schaible

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 13, p 7168 (2024)

In tumor cells, interleukin-6 (IL-6) signaling can lead to activation of the epidermal growth factor receptor (EGFR), which prolongs Stat3 activation. In the present experiments, we tested the hypothesis that IL-6 signaling activates EGFR signaling i

Externí odkaz: https://doaj.org/article/77a90efae71840f5961f0b48163bc03f

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Akademický článek

Gain-of-function mutation in SCN11A causes itch and affects neurogenic inflammation and muscle function in Scn11a+/L799P mice.

Autor: Matthias Ebbinghaus, Lorena Tuchscherr, Gisela Segond von Banchet, Lutz Liebmann, Volker Adams, Mieczyslaw Gajda, Christian A Hübner, Ingo Kurth, Hans-Georg Schaible

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237101 (2020)

Mutations in the genes encoding for voltage-gated sodium channels cause profound sensory disturbances and other symptoms dependent on the distribution of a particular channel subtype in different organs. Humans with the gain-of-function mutation p.Le

Externí odkaz: https://doaj.org/article/786e53ac74e947cdadd2571fb447c865

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Autor: Johannes Leuchtweis, Gisela Segond von Banchet, Matthias Ebbinghaus, Hans-Georg Schaible, Annett Eitner

Publikováno v: Pain. 161:1571-1583

Upon transient musculoskeletal diseases, some patients develop persistent pain while others recover from pain. Here, we studied whether such heterogeneity also occurs in rats after recovery from unilateral antigen-induced arthritis (AIA) in the knee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a04ea233710a629a479c2639f82e12b
https://doi.org/10.1097/j.pain.0000000000001852

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Spinal interleukin-1β induces mechanical spinal hyperexcitability in rats: Interactions and redundancies with TNF and IL-6

Autor: Christian König, Björn Vorpahl, Andrea Ebersberger, Matthias Ebbinghaus, Sabrina Eß, Hans-Georg Schaible, Enrique Vazquez

Publikováno v: Journal of neurochemistryReferences. 158(4)

Both spinal tumor necrosis factor (TNF) and interleukin-6 (IL-6) contribute to the development of "mechanical" spinal hyperexcitability in inflammatory pain states. Recently, we found that spinal sensitization by TNF was significantly reduced by bloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ad535c4dc45412775108aea95f1d62
https://pubmed.ncbi.nlm.nih.gov/34050952

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A Promising New Approach for the Treatment of Inflammatory Pain: Transfer of Stem Cell-Derived Tyrosine Hydroxylase-Positive Cells

Autor: Zsuzsa Jenei-Lanzl, Mieczyslaw Gajda, Rainer H. Straub, Hubert Stangl, Gisela Segond von Banchet, Hans-Georg Schaible, Matthias Ebbinghaus

Publikováno v: Neuroimmunomodulation. 25:225-237

Objectives: The appearance of endogenous tyrosine hydroxylase-positive cells (TH+ cells) in collagen-induced arthritis was associated with an anti-inflammatory effect. Here we investigated putative anti-inflammatory and antinociceptive effects of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938f5c9ff6cba9536f1d8baf8550350a
https://doi.org/10.1159/000495349

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Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis

Autor: Thomas Kamradt, Mieczyslaw Gajda, Hans-Georg Schaible, Firas Subhi Salah, Birgit Hoffmann, Gabriel Natura, Susanne Hensellek, Matthias Ebbinghaus, Martin Böttcher, Gisela Segond von Banchet

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports

Interleukin-17A (IL-17A) is considered an important pro-inflammatory cytokine but its importance in joint diseases such as rheumatoid arthritis (RA) is unclear. It has also been reported that IL-17A may induce pain but it is unclear whether pro-infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ab4dd433b8ad28c273d0fa71064074
http://link.springer.com/article/10.1038/s41598-017-10509-5

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Long-Lasting Activation of the Transcription Factor CREB in Sensory Neurons by Interleukin-1β During Antigen-Induced Arthritis in Rats: A Mechanism of Persistent Arthritis Pain?

Autor: Johannes Leuchtweis, Christian König, Gisela Segond von Banchet, Hans-Georg Schaible, Jessica Patzer, Matthias Ebbinghaus, Michael Karl Boettger, Annett Eitner

Publikováno v: Arthritis & Rheumatology. 68:532-541

Objective In spite of successful treatment of immune-mediated arthritis, many patients still experience pain. We undertook this study to investigate whether antigen-induced arthritis (AIA) in rats triggers neuronal changes in sensory neurons that out

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8470d0469a543dccfee4fada0c80e2e0
https://doi.org/10.1002/art.39445

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Gain-of-function mutation in SCN11A causes itch and affects neurogenic inflammation and muscle function in Scn11a+/L799P mice

Autor: Mieczyslaw Gajda, Matthias Ebbinghaus, Hans-Georg Schaible, Christian A. Hübner, Ingo Kurth, Gisela Segond von Banchet, Volker Adams, Lutz Liebmann, Lorena Tuchscherr

Publikováno v: PLoS ONE, Vol 15, Iss 8, p e0237101 (2020)
PLOS ONE 15(8), e0237101 (2020). doi:10.1371/journal.pone.0237101
PLoS ONE

PLoS ONE 15(8), e0237101 (2020). doi:10.1371/journal.pone.0237101
Published by PLOS, San Francisco, California, US

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3be0abd03cd450a9ca3f502633f67f
https://doi.org/10.1371/journal.pone.0237101

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Contribution of Inflammation and Bone Destruction to Pain in Arthritis: A Study in Murine Glucose-6-Phosphate Isomerase-Induced Arthritis

Autor: Matthias Ebbinghaus, Ingrid Hilger, Andreas Hess, Hans-Georg Schaible, Gisela Segond von Banchet, Sylvia Müller, Annett Eitner, Isabel Wank, Thomas Kamradt

Publikováno v: Arthritisrheumatology (Hoboken, N.J.)References. 71(12)

OBJECTIVE Arthritis is often characterized by inflammation and bone destruction. This study was undertaken to investigate the contribution of inflammation and bone destruction to pain. METHODS Inflammation, bone resorption, pain-related behaviors, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d85f9e08669909c82ec1c3cd283a770
https://pubmed.ncbi.nlm.nih.gov/31332965

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Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death

Autor: Z-Q Wang, Heinrich Betz, Rolf Bräuer, K R D Al-Saadi, Matthias Ebbinghaus, Gregory A. O'Sullivan, Vijaykumar Yogesh Muley, M Pacyna-Gengelbach, Zhong-Wei Zhou, Iver Petersen, Rainer König, F S Salah

Publikováno v: Cell Death and Disease
Cell death & disease, 7: e2205
Cell Death & Disease

GABARAP belongs to an evolutionary highly conserved gene family that has a fundamental role in autophagy. There is ample evidence for a crosstalk between autophagy and apoptosis as well as the immune response. However, the molecular details for these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef8ad4d744dd3cde526d63f9cdc5381
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42524

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