JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis

Autor: Matthias D. Sury, Claudia Agarinis, Hans-Rudolf Widmer, Stephen L. Leib, Stephan Christen

Publikováno v: Neurobiology of Disease, Vol 32, Iss 1, Pp 142-150 (2008)

Pneumococcal meningitis is associated with caspase 3-dependent apoptosis of recently post-mitotic immature neurons in the dentate gyrus of the hippocampus. The death of these cells is implicated in the learning and memory deficits in patients survivi

Externí odkaz: https://doaj.org/article/acd9d6c8ebe443348b01e6d43a5f8a48

Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis

Autor: Lorianne Vorlet-Fawer, Matthias D. Sury, Denis Grandgirard, Stephen L. Leib, Claudia Agarinis, Stephan Christen, Shida Yousefi

Publikováno v: Neurobiology of disease
Sury, Matthias D.; Vorlet-Fawer, Lorianne; Agarinis, Claudia; Yousefi, Shida; Grandgirard, Denis; Leib, Stephen L.; Christen, Stephan (2011). Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease, 41(1), pp. 201-208. Amsterdam: Elsevier 10.1016/j.nbd.2010.09.007
Neurobiology of Disease, Vol 41, Iss 1, Pp 201-208 (2011)

Pneumococcal meningitis causes apoptosis of developing neurons in the dentate gyrus of the hippocampus. The death of these cells is accompanied with long-term learning and memory deficits in meningitis survivors. Here, we studied the role of the PI3K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d455dc7dfaeedff9737dde2088524c6e
https://doi.org/10.1016/j.nbd.2010.09.007

miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism*

Autor: Varun Pandey, Matthias Selbach, Lena Eliasson, Hans-Hermann Wessels, Jean Hausser, Robert P. Zinzen, Thomas Rathjen, Matthias D. Sury, Inês G. Mollet, Martin Jastroch, Sudhir Gopal Tattikota, Uma D. Kabra, Marc R. Friedländer, Matthias H. Tschöp, Aditya Khedkar, Matthew N. Poy, Mihaela Zavolan, Sebastian Kadener

Publikováno v: J. Biol. Chem. 290, 20284-20294 (2015)
Journal of Biological Chemistry; 290(33), pp 20284-20294 (2015)

In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however the pathways governing this adaptive response are not entirely established. While the precise role of microRNAs (miRNAs) is also unclear, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25305055dc44bba95c561cfa5fda4b3
https://europepmc.org/articles/PMC4536436/

In vivo stable isotope labeling by amino acids in Drosophila melanogaster

Autor: Matthias D, Sury, Jia-Xuan, Chen, Matthias, Selbach

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1188

The fruit fly Drosophila melanogaster is one of the most widely used and well-studied model organisms in biology and therefore a promising tool for quantitative proteomics. Here, we describe a method to label D. melanogaster with stable isotope label

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9bfe5543d468acc84be102ac2016c86c
https://pubmed.ncbi.nlm.nih.gov/25059606

Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase

Autor: Stephan Christen, Manuela Frese-Schaper, Matthias D. Sury, Sidney Shaw, Ingolf E. Blasig, Fabienne T. Schulthess, Martin G. Täuber, Miranda K. Mühlemann

Publikováno v: Free radical biologymedicine. 41(9)

N-acetylcysteine (NAC) is neuroprotective in animal models of acute brain injury such as caused by bacterial meningitis. However, the mechanism(s) by which NAC exerts neuroprotection is unclear. Gene expression of endothelin-1 (ET-1), which contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3834f3c6629203371d1c323f1978565
https://pubmed.ncbi.nlm.nih.gov/17023264