Protective Effects of Statin Therapy in Cirrhosis Are Limited by a Common SLCO1B1 Transporter Variant

Autor: Melissa Merkel, Christina Schneider, Robin Greinert, Alexander Zipprich, Cristina Ripoll, Frank Lammert, Matthias C. Reichert

Publikováno v: Hepatology Communications, Vol 5, Iss 10, Pp 1755-1766 (2021)

Complications of cirrhosis and portal hypertension (PH) can be reduced by statin therapy. The common loss‐of‐function variant p.V174A in the solute carrier organic anion transporter gene 1B1 (SLCO1B1) gene encoding the organic anion transporting

Externí odkaz: https://doaj.org/article/546ba60e1a414514be91daceaba7708c

NOD2 gene variants confer risk for secondary sclerosing cholangitis in critically ill patients

Autor: Christoph Jüngst, Vanessa Stadlbauer, Matthias C. Reichert, Vincent Zimmer, Susanne N. Weber, Lisa Ofner-Ziegenfuß, Torsten Voigtländer, Walter Spindelböck, Peter Fickert, Gabriele I. Kirchner, Frank Lammert, Tim O. Lankisch, Marcin Krawczyk

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)

Abstract Sclerosing cholangitis in critically ill patients (SC-CIP) is a progressive cholestatic disease of unknown aetiology characterized by chronic biliary infections. Hence we hypothesized that common NOD2 (nucleotide-binding oligomerisation doma

Externí odkaz: https://doaj.org/article/a695bed299964c64a45f7272a191bee3

Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers

Autor: Mattias Mandorfer, Nadine T. Gaisa, Christian Trautwein, Jef Verbeek, Helmut Denk, Daniel Neureiter, Elmar Aigner, Julia Kümpers, Heinz Zoller, Barbara Burbaum, LS Moeller, Heike Bantel, Olivier Govaere, Federica Benini, Joanna Chorostowska-Wynimko, Aleksander Krag, Frank Lammert, Jacob George, Katharina Wöran, Thomas Reiberger, Georg Lurje, Marla Gutberlet, Felix Stickel, Lisa Bewersdorf, Michael Trauner, Mohammed Eslam, V Woditsch, Sabina Janciauskiene, Tania Roskams, V Pereira, Johannes Haybaeck, J. Voss, Karim Hamesch, C Lindhauer, Annika Gross, Andreas Geier, Mònica Pons, Malin Fromme, Alexander Teumer, Quentin M. Anstee, Joan Genescà, Matthias C. Reichert, Biaohuan Zhou, Pawel Kuca, Marcin Krawczyk, Carolin V. Schneider, Pavel Strnad, Timm Dirrichs, Christian Datz, Joana Carvão, Robert Bals, Frederik Nevens, Benedikt Schäfer

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Schneider, C V, Hamesch, K, Gross, A, Mandorfer, M, Moeller, L S, Pereira, V, Pons, M, Kuca, P, Reichert, M C, Benini, F, Burbaum, B, Voss, J, Gutberlet, M, Woditsch, V, Lindhauer, C, Fromme, M, Kümpers, J, Bewersdorf, L, Schäfer, B, Eslam, M, Bals, R, Janciauskiene, S, Carvão, J, Neureiter, D, Zhou, B, Wöran, K, Bantel, H, Geier, A, Dirrichs, T, Stickel, F, Teumer, A, Verbeek, J, Nevens, F, Govaere, O, Krawczyk, M, Roskams, T, Haybaeck, J, Lurje, G, Chorostowska-Wynimko, J, Genesca, J, Reiberger, T, Zoller, H, Lammert, F, Krag, A, George, J, Anstee, Q M, Trauner, M, Datz, C, Gaisa, N T, Denk, H & European Alpha-1 Liver Study Group 2020, ' Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers ', Gastroenterology, vol. 159, no. 2, pp. 534-548.e11 . https://doi.org/10.1053/j.gastro.2020.04.058

BACKGROUND & AIMS: Homozygosity for the Pi∗Z variant of the gene that encodes the alpha-1 antitrypsin peptide (AAT), called the Pi∗ZZ genotype, causes a liver and lung disease called alpha-1 antitrypsin deficiency. Heterozygosity (the Pi∗MZ gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59dc7827cb0387e946e44ea0d463025

Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency

Autor: Alice M Turner, David A. Lomas, Alexa Nuñez, Sabina Janciauskiene, William J.H. Griffiths, Christian Trautwein, Joan Genescà, Michael Trauner, John R. Hurst, Jef Verbeek, Matthias C. Reichert, Guilherme Macedo, Ravi Mahadeva, Mònica Pons, Aleksander Krag, Rui Gaspar, V Pereira, Heinz Zoller, Catarina Gomes, Mattias Mandorfer, Barbara Burbaum, Frank Lammert, V Woditsch, Paul Ellis, Aileen Marshall, Douglas Thorburn, Nadine T. Gaisa, Karim Hamesch, Joanna Chorostowska-Wynimko, Luís Jasmins, Malin Fromme, Rodrigo Liberal, Pavel Strnad, Frederik Nevens, Noel G. McElvaney, Marc Miravitlles, Virginia Clark, Bibek Gooptu, Benedikt Schaefer, Katrine Holtz Thorhauge, Carolin V. Schneider, Nelia Abreu, Kai Markus Schneider, Federica Benini

Publikováno v: Fromme, M, Schneider, C V, Pereira, V, Hamesch, K, Pons, M, Reichert, M C, Benini, F, Ellis, P, H Thorhauge, K, Mandorfer, M, Burbaum, B, Woditsch, V, Chorostowska-Wynimko, J, Verbeek, J, Nevens, F, Genesca, J, Miravitlles, M, Nuñez, A, Schaefer, B, Zoller, H, Janciauskiene, S, Abreu, N, Jasmins, L, Gaspar, R, Gomes, C, Schneider, K M, Trauner, M, Krag, A, Gooptu, B, Thorburn, D, Marshall, A, Hurst, J R, Lomas, D A, Lammert, F, Gaisa, N T, Clark, V, Griffiths, W, Trautwein, C, Turner, A M, McElvaney, N G & Strnad, P 2022, ' Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency ', GUT, vol. 71, no. 2, pp. 415-423 . https://doi.org/10.1136/gutjnl-2020-323729

ObjectiveAlpha-1 antitrypsin deficiency (AATD) is a common, potentially lethal inborn disorder caused by mutations in alpha-1 antitrypsin (AAT). Homozygosity for the ‘Pi*Z’ variant of AAT (Pi*ZZ genotype) causes lung and liver disease, whereas he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bb0b61df320d870e692517692e26a5
https://findresearcher.sdu.dk:8443/ws/files/181414680/Revised_Manuscript_Supplement_SZ_210105_Gut.pdf

Einfluss der Augmentationstherapie mit Alpha1-Antitrypsin auf den Leberphänotyp von Individuen mit klassischem Alpha1-Antitrypsin-Mangel (Genotyp Pi*ZZ)

Autor: Matthias C. Reichert, C Lindhauer, M Mandorfer, Robert Bals, Elmar Aigner, Thorhauge K Holtz, Joan Genescà, Rembert Koczulla, Carolin V. Schneider, Aleksander Krag, V Woditsch, A Teumer, Joanna Chorostowska-Wynimko, Pavel Strnad, Christian Trautwein, Karim Hamesch, William J.H. Griffiths, Marc Miravitlles, Malin Fromme, Federica Benini, Sabina Janciauskiene, M Trauner, Frank Lammert, V Pereira, Mònica Pons, J Voß

Publikováno v: Fromme, M, Hamesch, K, Schneider, C V, Mandorfer, T, Holtz, T K, Perera, R, Pons, M, Reichert, M, Woditsch, V, Voß, J, Lindhauer, C, Bals, R, Koczulla, R A, Miravitlles, M, Janciauskiene, S, Lammert, F, Genescà, J, Benini, F, Chorostowska-Wynimko, J, Griffiths, W J, Aigner, E, Trauner, M, Krag, A, Trautwein, C & Strnad, P 2021, ' Einfluss der Augmentationstherapie mit Alpha1-Antitrypsin auf den Leberphänotyp von Individuen mit klassischem Alpha1-Antitrypsin-Mangel (Genotyp Pi*ZZ) ', Zeitschrift fuer Gastroenterologie, bind 59, nr. 8, e226 . https://doi.org/10.1055/s-0041-1733662

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caadb02d4e3c99a4e1dad882075f24e
https://portal.findresearcher.sdu.dk/da/publications/0c2a0b64-c1e9-4796-879f-3b0699b52107