Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Matthias Brewer"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic target for endocrine, metabolic and stress-related disorders. However, many questions regarding the protein structure and dy
Externí odkaz:
https://doaj.org/article/a346ec78510746d69585d21cdea38cc6
Autor:
Matthias Brewer, Evan M. Howard
Publikováno v:
ACS Catalysis. 11:12203-12207
Publikováno v:
Angewandte Chemie International Edition. 59:12827-12831
Structurally complex diazo-containing scaffolds are formed by conjugate addition to vinyl diazonium salts. The electrophile, a little studied α-diazonium-α,β-unsaturated carbonyl compound, is formed at low temperature under mild conditions by trea
Publikováno v:
Tetrahedron Letters. 109:154137
Publikováno v:
Org Lett
Substituted α-alkylidene cyclopentenones are formed in up to 93% yield by the intramolecular capture of vinyl cations with pendent alkenes. An increased level of substitution at the β-position of the β-hydroxy-α-diazoketone starting material chan
Publikováno v:
J Org Chem
The Lewis acid-promoted generation of destabilized vinyl cations from β-hydroxy diazo ketones leads to an energetically favorable 1,2-shift across the alkene followed by an irreversible C-H insertion to give cyclopentenone products. This reaction se
Autor:
Victor May, Karen M. Braas, David Chatenet, Chenyi Liao, Gaojie Song, Severin T. Schneebeli, Matthias Brewer, Jianing Li, Mathilde Poujol de Molliens
Publikováno v:
Current Topics in Medicinal Chemistry. 19:1399-1417
The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to
Publikováno v:
The Journal of Organic Chemistry. 83:6202-6209
Intramolecular [4 + 2]-cycloaddition of heteroallene salts gives polycyclic tetrahydrocinnoline structures that contain an N-aminoiminium motif. Deprotonation with mild base gives the corresponding azomethine imines, which readily participate in 1,3-
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Scientific Reports
Scientific Reports
The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic target for endocrine, metabolic and stress-related disorders. However, many questions regarding the protein structure and dynamics of
Publikováno v:
The Journal of Organic Chemistry. 82:4001-4005
Cationic 1-aza-2-azoniaallene salts react with structurally constrained alkenes in intramolecular reactions by C-H insertion at the allylic position, or by (2+1)-cycloaddition with the alkene followed by ring opening. The latter reaction gives furthe