Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Matthias Bechtold"'
Autor:
Matthias Bechtold, Sven Panke
Publikováno v:
CHIMIA, Vol 63, Iss 6 (2009)
Biocatalysis constitutes an effective tool for the production of fine chemicals. In order to widen the spectrum of applicable reaction types to reactions that are constrained by inhibitions, product toxicity, or degradation, an unfavorable position o
Externí odkaz:
https://doaj.org/article/14a19a4a23a1472f8c4a7095cfec00fd
Publikováno v:
Metabolic Engineering. 59:15-23
Scoring changes in enzyme or pathway performance by their effect on growth behavior is a widely applied strategy for identifying improved biocatalysts. While in directed evolution this strategy is powerful in removing non-functional catalysts in sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2b963a5678226be3b2fc96907f10c6
https://doi.org/10.1016/j.ymben.2020.01.003
https://doi.org/10.1016/j.ymben.2020.01.003
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 117(9)
Enzymes are industrially applied under increasingly diverse environmental conditions that are dictated by the efforts to optimize overall process efficiency. Engineering the operational stability of biocatalysts to enhance their half-lives under the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8df6edb3d4a58e7cc5984bde4fea1c
https://pubmed.ncbi.nlm.nih.gov/32492177
https://pubmed.ncbi.nlm.nih.gov/32492177
Publikováno v:
Chemical Engineering Science. 137:423-435
The integration of biocatalysis with continuous separation of product and substrate constitutes an attractive option for overcoming the intrinsic yield limitation in enzymatic reactions that suffer from an unfavourable position of the equilibrium. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7343d2b34f4a165bfeee9ccb07abd53a
https://doi.org/10.1016/j.ces.2015.05.058
https://doi.org/10.1016/j.ces.2015.05.058
Publikováno v:
Biotechnology and Bioengineering. 113:349-358
Rare sugars are monosaccharides that do not occur in nature in large amounts. However, many of them demonstrate high potential as low-calorie sweetener, chiral building blocks or active pharmaceutical ingredients. Their production by enzymatic means
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2e917181d2a8dc823aed5e8d56877da
https://doi.org/10.1002/bit.25547
https://doi.org/10.1002/bit.25547
Publikováno v:
Angewandte Chemie International Edition. 54:4182-4186
Enzyme cascades combining epimerization and isomerization steps offer an attractive route for the generic production of rare sugars starting from accessible bulk sugars but suffer from the unfavorable position of the thermodynamic equilibrium, thus r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932f03754b7edef1074be4898d86603e
https://doi.org/10.1002/anie.201411279
https://doi.org/10.1002/anie.201411279
Publikováno v:
Applied microbiology and biotechnology. 100(17)
Chiral resolutions of racemic mixtures are limited to a theoretical yield of 50 %. This yield can be doubled by integration of a step-wise or continuous racemization of the non-desired enantiomer. Many of the different routes along which the racemiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::259f27c32e782c132766edf3b5f9d8d2
https://pubmed.ncbi.nlm.nih.gov/27444433
https://pubmed.ncbi.nlm.nih.gov/27444433
Integration of enantioseparation by simulated moving bed (SMB) and mild enzymatic racemization enables the production of single enantiomers from a racemic mixture in theoretically 100% yield and hence overcomes the 50% yield limitation of conventiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacff938cd7e5acd5d808f1e1ea01f1e
http://hdl.handle.net/11311/1129583
http://hdl.handle.net/11311/1129583
Autor:
Fabio Parmeggiani, Elisabetta Brenna, Matthias Bechtold, Sven Panke, Christian Femmer, Alessandro Sacchetti, Francesco G. Gatti
Publikováno v:
Organic Process Research & Development. 16:269-276
The coupling of the enantioselective reduction catalyzed by Old Yellow Enzymes (OYEs), together with the in situ substrate feeding product removal (SFPR) concept, significantly improved the productivity of the g-scale preparation of ethyl (S)-2-ethox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b28a79754ea2ae3eb1ad6ac73c47df3
https://doi.org/10.1021/op200085k
https://doi.org/10.1021/op200085k
Publikováno v:
Organic Process Research & Development. 16:323-330
Integrated operation of biotransformation and simulated moving bed (SMB) separation is an attractive option for high-yield manufacturing of commercially relevant compounds such as rare sugars and sialic acids from equilibrium-limited isomerase- or al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc1eac7c2726bbc51790b2adfac4a5f
https://doi.org/10.1021/op200160e
https://doi.org/10.1021/op200160e