Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Matthias Barz"'
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract This review describes the formation of a protein corona (or its absence) on different classes of nanoparticles, its basic principles, and its consequences for nanomedicine. For this purpose, it describes general concepts to control (guide/mi
Externí odkaz:
https://doaj.org/article/dd81ac2606254cbeb36f2529a668a0a1
Autor:
Christina Breder-Bonk, Dominic Docter, Matthias Barz, Sebastian Strieth, Shirley K. Knauer, Désirée Gül, Roland H. Stauber
Publikováno v:
Nanomaterials, Vol 13, Iss 18, p 2546 (2023)
Exposure to nanoparticles is inevitable as they become widely used in industry, cosmetics, and foods. However, knowledge of their (patho)physiological effects on biological entry routes of the human body and their underlying molecular mechanisms is s
Externí odkaz:
https://doaj.org/article/959508a8fd9145a1864da699a77efff9
Autor:
Christoph Wilhelmy, Isabell Sofia Keil, Lukas Uebbing, Martin A. Schroer, Daniel Franke, Thomas Nawroth, Matthias Barz, Ugur Sahin, Heinrich Haas, Mustafa Diken, Peter Langguth
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2068 (2023)
Lipid nanoparticles (LNPs) have gained great attention as carriers for mRNA-based therapeutics, finding applications in various indications, extending beyond their recent use in vaccines for infectious diseases. However, many aspects of LNP structure
Externí odkaz:
https://doaj.org/article/0661639078014c83ae3f7dc08cc22219
Autor:
Kerstin Johann, Toszka Bohn, Fatemeh Shahneh, Natascha Luther, Alexander Birke, Henriette Jaurich, Mark Helm, Matthias Klein, Verena K. Raker, Tobias Bopp, Matthias Barz, Christian Becker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The acidic tumour microenvironment in melanoma drives immune evasion by cAMP in tumor-infiltrating monocytes. Here, the authors show that the release of an adenylate cyclase inhibitor from micelles restores antitumor immunity and, when combined with
Externí odkaz:
https://doaj.org/article/7bf68961413a4a0db798c0e43c2d024c
Autor:
Nils-Jørgen Knudsen Dal, Martin Speth, Kerstin Johann, Matthias Barz, Claire Beauvineau, Jens Wohlmann, Federico Fenaroli, Brigitte Gicquel, Gareth Griffiths, Noelia Alonso-Rodriguez
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
With the increasing emergence of drug-resistant Mycobacterium tuberculosis strains, new and effective antibiotics against tuberculosis (TB) are urgently needed. However, the high frequency of poorly water-soluble compounds among hits in high-throughp
Externí odkaz:
https://doaj.org/article/ad046bb641e6403683ba9d4f8d557cee
Autor:
Inka Negwer, Andreas Best, Meike Schinnerer, Olga Schäfer, Leon Capeloa, Manfred Wagner, Manfred Schmidt, Volker Mailänder, Mark Helm, Matthias Barz, Hans-Jürgen Butt, Kaloian Koynov
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
While nanocarrier-based drug delivery is a promising therapeutic approach, in situ characterization of drug nanocarriers in blood remains difficult. Here, the authors demonstrate how the fluorescence correlation spectroscopy can be used to directly c
Externí odkaz:
https://doaj.org/article/cf29261ca73b441fab35b8f08719a659
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 16, Iss , Pp 543-550 (2018)
Nanoparticles coated with hydrophilic polymers often show a reduction in unspecific interactions with the biological environment, which improves their biocompatibility. The molecular determinants of this reduction are not very well understood yet, an
Externí odkaz:
https://doaj.org/article/2d98f77e0054418e81d74e4345af6e40
Autor:
Philipp Michael Klein, Kristina Klinker, Wei Zhang, Sarah Kern, Eva Kessel, Ernst Wagner, Matthias Barz
Publikováno v:
Polymers, Vol 10, Iss 6, p 689 (2018)
Shielding agents are commonly used to shield polyelectrolyte complexes, e.g., polyplexes, from agglomeration and precipitation in complex media like blood, and thus enhance their in vivo circulation times. Since up to now primarily poly(ethylene glyc
Externí odkaz:
https://doaj.org/article/d4d52be063004dc79634a5e4ca2844b6
Autor:
Simone Beck, Jennifer Schultze, Hans-Joachim Räder, Regina Holm, Meike Schinnerer, Matthias Barz, Kaloian Koynov, Rudolf Zentel
Publikováno v:
Polymers, Vol 10, Iss 2, p 141 (2018)
The design of multifunctional polymer-based vectors, forming pDNA vaccines, offers great potential in cancer immune therapy. The transfection of dendritic immune cells (DCs) with tumour antigen-encoding pDNA leads to an activation of the immune syste
Externí odkaz:
https://doaj.org/article/bd11e5163ef94751bb78fffdfadcee05
Autor:
Benjamin Weber, Christine Seidl, David Schwiertz, Martin Scherer, Stefan Bleher, Regine Süss, Matthias Barz
Publikováno v:
Polymers, Vol 8, Iss 12, p 427 (2016)
Amphiphiles and, in particular, PEGylated lipids or alkyl ethers represent an important class of non-ionic surfactants and have become key ingredients for long-circulating (“stealth”) liposomes. While poly-(ethylene glycol) (PEG) can be considere
Externí odkaz:
https://doaj.org/article/8d154b847b784b26b99faeba03138cb1