Clinical prognosticators and targets in the immune microenvironment of intrahepatic cholangiocarcinoma

Autor: Isis Lozzi, Alexander Arnold, Matthias Barone, Juliette Claire Johnson, Bruno V Sinn, Johannes Eschrich, Pimrapat Gebert, Ruonan Wang, Mengwen Hu, Linda Feldbrügge, Anja Schirmeier, Anja Reutzel-Selke, Thomas Malinka, Felix Krenzien, Wenzel Schöning, Dominik P Modest, Johann Pratschke, Igor M Sauer, Matthäus Felsenstein

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

Background Intrahepatic cholangiocarcinoma (ICC) is a disease with poor prognosis and limited therapeutic options. We investigated the tumor immune microenvironment (TIME) to identify predictors of disease outcome and to explore targets for therapeut

Externí odkaz: https://doaj.org/article/e0446c6ce3f8424696faa2dce6d8a997

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Autor: Philipp Georg, Rosario Astaburuaga-García, Lorenzo Bonaguro, Sophia Brumhard, Laura Michalick, Lena J. Lippert, Tomislav Kostevc, Christiane Gäbel, Maria Schneider, Mathias Streitz, Vadim Demichev, Ioanna Gemünd, Matthias Barone, Pinkus Tober-Lau, Elisa Theresa Helbig, Julia Stein, Hannah-Philine Dey, Daniela Paclik, Michael Mülleder, Simran Kaur Aulakh, Henrik E. Mei, Axel R. Schulz, Stefan Hippenstiel, Victor Max Corman, Dieter Beule, Emanuel Wyler, Markus Landthaler, Benedikt Obermayer-Wasserscheid, Peter Boor, Münevver Demir, Hans Wesselmann, Norbert Suttorp, Alexander Uhrig, Holger Müller-Redetzky, Jacob Nattermann, Wolfgang M. Kuebler, Christian Meisel, Markus Ralser, Joachim L. Schultze, Anna C. Aschenbrenner, Charlotte Thibeault, Florian Kurth, Leif-Erik Sander, Nils Blüthgen, Birgit Sawitzki

SummarySevere COVID-19 is linked to both dysfunctional immune response and unrestrained immunopathogenesis, and it remains unclear if T cells also contribute to disease pathology. Here, we combined single-cell transcriptomics and proteomics with mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89aba5a5afc97e368ed42a3c27691dcb
https://doi.org/10.1101/2021.06.08.21258481

Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells

Autor: Jiang Ren, Judith Bruns, Peter Lindemann, Kathrin Motzny, Ronald Kühne, Slim Chiha, Matthias M. Müller, Monika Beerbaum, Robert Opitz, Stephan Dohmen, Matthias Barone, Arne Soicke, Marco Tobias Klein, Dominik Albat, Peter Schmieder, Udo Heinemann, Hartmut Oschkinat, Yvette Roske, Marc Nazaré, Hans-Günther Schmalz, Peter ten Dijke, Rudolf Volkmer, Maarten van Dinther

Publikováno v: Proceedings of the National Academy of Sciences, 117(47), 29684-29690. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America

Significance Protein–protein interactions mediated by proline-rich motifs are involved in regulation of many important signaling cascades. These motifs belong to the most abundant recognition motifs in the eukaryotic genome and preferentially adopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3f020fdbbb67aa9a4b024f1290a866
https://hdl.handle.net/1887/3185199

Design and Stereoselective Synthesis of ProM-2: A Spirocyclic Diproline Mimetic with Polyproline Type II (PPII) Helix Conformation

Autor: Marco Tobias Klein, Slim Chiha, Robert Opitz, Arne Soicke, Matthias Barone, Hans-Günther Schmalz, Jörg-Martin Neudörfl, Cédric Reuter, Ronald Kühne, Stephan Dohmen

Publikováno v: Chemistry - A European Journal. 21:8464-8470

With the aim of developing polyproline type II helix (PPII) secondary-structure mimetics for the modulation of prolin-rich-mediated protein-protein interactions, the novel diproline mimetic ProM-2 was designed by bridging the two pyrrolidine rings of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706a50a8470c1195813f621aa2a94e9e
https://doi.org/10.1002/chem.201406493