Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Matthias B. Wittwer"'
Autor:
Claudia Gonzalo-Consuegra, Irene Santos-García, Laura García-Toscano, Raquel Martín-Baquero, Carmen Rodríguez-Cueto, Matthias B. Wittwer, Pawel Dzygiel, Uwe Grether, Eva de Lago, Javier Fernández-Ruiz
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116473- (2024)
Background: The elevation of endocannabinoid levels through inhibiting their degradation afforded neuroprotection in CaMKIIα-TDP-43 mice, a conditional transgenic model of frontotemporal dementia. However, which cannabinoid receptors are mediating t
Externí odkaz:
https://doaj.org/article/c348e372aa8949cf995edfd5d615612e
Autor:
Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG) and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical potential is limited by central nervous system (CNS)-mediated s
Externí odkaz:
https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f
Autor:
Maciej J, Zamek-Gliszczynski, Vishal, Sangha, Hong, Shen, Bo, Feng, Matthias B, Wittwer, Manthena V S, Varma, Xiaomin, Liang, Yuichi, Sugiyama, Lei, Zhang, Reina, Bendayan
Publikováno v:
Clinical Pharmacology & Therapeutics. 112:485-500
During its fourth transporter workshop in 2021, the International Transporter Consortium (ITC) provided updates on emerging clinically relevant transporters for drug development. Previously highlighted and new transporters were considered based on up
Autor:
Sara C Humphreys, John A Davis, Sajida Iqbal, Amin Kamel, Kenneth Kulmatycki, Yanbin Lao, Xiumin Liu, John Rodgers, Jan Snoeys, Adam Vigil, Yan Weng, Christopher M Wiethoff, Matthias B Wittwer
Publikováno v:
Nucleic Acids Research. 50:6020-6037
At the time of writing, although siRNA therapeutics are approved for human use, no official regulatory guidance specific to this modality is available. In the absence of guidance, preclinical development for siRNA followed a hybrid of the small molec
Autor:
Yingfang He, Luca C. Gobbi, Adrienne Müller Herde, Didier Rombach, Martin Ritter, Bernd Kuhn, Matthias B. Wittwer, Dominik Heer, Benoit Hornsperger, Charles Bell, Fionn O'Hara, Jörg Benz, Michael Honer, Claudia Keller, Ludovic Collin, Hans Richter, Roger Schibli, Uwe Grether, Linjing Mu
Publikováno v:
Nuclear Medicine and Biology, 108-109
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the endocannabinoid degradation in the brain. It has recently emerged as a promising therapeutic target in the treatment of neuroinflammatory and neurodegenerative d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce52a586caa948df1c940c2253b3a130
https://hdl.handle.net/20.500.11850/536205
https://hdl.handle.net/20.500.11850/536205
Autor:
Mohammed Ullah, Kenichi Umehara, Carina Cantrill, Florian Klammers, Aynur Ekiciler, Neil Parrott, Stephen Fowler, Elisa Di Lenarda, Matthias B. Wittwer
Publikováno v:
Drug Metabolism and Disposition. 48:849-860
In vitro to in vivo extrapolation (IVIVE) to predict human hepatic clearance, including metabolism and transport, requires extensive experimental resources. In addition, there may be technical challenges to measure low clearance values. Therefore, pr
Autor:
Yingfang He, Uwe Grether, Marco F. Taddio, Carla Meier, Claudia Keller, Martin R. Edelmann, Michael Honer, Sylwia Huber, Matthias B. Wittwer, Dominik Heer, Hans Richter, Ludovic Collin, Melanie N. Hug, Manuel Hilbert, Annemarieke G.J. Postmus, Anna Floor Stevens, Mario van der Stelt, Stefanie D. Krämer, Roger Schibli, Linjing Mu, Luca C. Gobbi
Publikováno v:
European Journal of Medicinal Chemistry, 243:114750. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
European Journal of Medicinal Chemistry, 243
European Journal of Medicinal Chemistry, 243
Monoacylglycerol lipase (MAGL) is a gatekeeper in regulating endocannabinoid signaling and has gained substantial attention as a therapeutic target for neurological disorders. We recently discovered a morpholin-3-one derivative as a novel scaffold fo
Autor:
Lyn H, Jones, Constance A, Mitchell, Lise, Loberg, Mira, Pavkovic, Mohan, Rao, Ruth, Roberts, Katie, Stamp, Laurie, Volak, Matthias B, Wittwer, Syril, Pettit
Publikováno v:
Nature Reviews Drug Discovery. 21:401-402
Autor:
Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa
Publikováno v:
Nature Chemical Biology, 16(6), 667-675
Nat Chem Biol
Nat Chem Biol
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858eb516053df2c6e71eaf7ba6acceef
https://www.nature.com/articles/s41589-020-0528-7
https://www.nature.com/articles/s41589-020-0528-7
Autor:
Carina Cantrill, Caroline Rynn, Prasoon Chaturvedi, Matthias B. Wittwer, Isabelle Walter, Jeannine Petrig Schaffland
Publikováno v:
Drug discovery today. 25(6)
Targeted protein degraders are an emerging modality. Their properties fall outside the traditional small-molecule property space and are in the 'beyond rule of 5' space. Consequently, drug discovery programs focused on developing orally bioavailable