Výsledky vyhledávání - "Matthias A. Fügi"

Akademický článek

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

Autor: Matthias A. Fügi, Kapila Gunasekera, Torsten Ochsenreiter, Xueli Guan, Markus R. Wenk, Pascal Mäser

Publikováno v: Journal of Lipid Research, Vol 55, Iss 5, Pp 929-938 (2014)

Sterols are an essential class of lipids in eukaryotes, where they serve as structural components of membranes and play important roles as signaling molecules. Sterols are also of high pharmacological significance: cholesterol-lowering drugs are bloc

Externí odkaz: https://doaj.org/article/43f8f0e9fb4e4aa59ee56194ea101cf6

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Match-making for posaconazole through systems thinking

Autor: Roger Schneiter, Xue Li Guan, Pascal Mäser, Marcel Kaiser, Marcel Tanner, Matthias A. Fügi

Publikováno v: Trends in parasitology. 31(2)

Currently available drugs for Chagas' disease are limited by toxicity and low efficacy in the chronic stage. Posaconazole, the most advanced new anti-chagasic drug candidate, did not fully confirm its initial potential in a Phase II clinical trial fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5c0b929c231e8357a159f331a6bee0
https://pubmed.ncbi.nlm.nih.gov/25486978

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Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

Autor: Torsten Ochsenreiter, Markus R. Wenk, Pascal Mäser, Kapila Gunasekera, Xue Li Guan, Matthias A. Fügi

Publikováno v: Journal of Lipid Research, Vol 55, Iss 5, Pp 929-938 (2014)
Journal of lipid research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5a873ab561d7eaf559317859a488b2
https://europepmc.org/articles/PMC3995470/

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Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals ▿

Autor: Jonathan L. Vennerstrom, Sergio Wittlin, Matthias A. Fügi, Yuxiang Dong

Peroxidic antimalarials such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still not well understood. Using combination experiments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f1cc9fed5923c526d9d0a69f35145d
https://europepmc.org/articles/PMC2825978/

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