Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Matthias Eckhardt"'
Autor:
Thomas Mika, Deepak Vangala, Matthias Eckhardt, Paul La Rosée, Christoph Lange, Kai Lehmberg, Charlotte Wohlschläger, Saskia Biskup, Ilka Fuchs, Jasmin Mann, Stephan Ehl, Klaus Warnatz, Roland Schroers
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Hemophagocytic lymphohistiocytosis (HLH) is a disorder of uncontrolled immune activation with distinct clinical features including fever, cytopenia, splenomegaly, and sepsis-like symptoms. In a young adolescent patient a novel germline GATA2 variant
Externí odkaz:
https://doaj.org/article/c458839039cf429d97ae8978a6f9df55
Publikováno v:
Cells, Vol 10, Iss 12, p 3520 (2021)
Sulfatide synthesis in the human renal cancer cell line SMKT-R3 was strongly inhibited in the presence of low µM concentrations of AG-205, a progesterone receptor membrane component 1 (PGRMC1) antagonist. This was also the case in Chinese hamster ov
Externí odkaz:
https://doaj.org/article/ca80c5dab9394dcfaf0938a281ce9215
Autor:
Johanna von Gerichten, Kerstin Schlosser, Dominic Lamprecht, Ivan Morace, Matthias Eckhardt, Dagmar Wachten, Richard Jennemann, Hermann-Josef Gröne, Matthias Mack, Roger Sandhoff
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1247-1258 (2017)
Mammals synthesize, cell-type specifically, the diastereomeric hexosylceramides, β-galactosylceramide (GalCer) and β-glucosylceramide (GlcCer), which are involved in several diseases, such as sphingolipidosis, diabetes, chronic kidney diseases, or
Externí odkaz:
https://doaj.org/article/c86c3de3fab0410f9a9efffb263caea3
Autor:
Silvia Jordans, Robert Hardt, Ivonne Becker, Dominic Winter, Lihua Wang-Eckhardt, Matthias Eckhardt
Publikováno v:
Molecular Neurobiology. 59:3969-3979
PNS and CNS myelin contain large amounts of galactocerebroside and sulfatide with 2-hydroxylated fatty acids. The underlying hydroxylation reaction is catalyzed by fatty acid 2-hydroxylase (FA2H). Deficiency in this enzyme causes a complicated heredi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9ce0bea1f18ba811c0b558fc2b8f5b
https://doi.org/10.1007/s12035-022-02832-4
https://doi.org/10.1007/s12035-022-02832-4
Autor:
Jan Spaas, Thibaux Van der Stede, Sarah de Jager, Annet van de Waterweg Berends, Assia Tiane, Hans Baelde, Shahid P. Baba, Matthias Eckhardt, Esther Wolfs, Tim Vanmierlo, Niels Hellings, Bert O. Eijnde, Wim Derave
Multiple sclerosis (MS) pathology features autoimmune-driven neuroinflammation, demyelination, and failed remyelination. Carnosine is a histidine-containing dipeptide (HCD) with pluripotent homeostatic properties that is able to improve outcomes in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59e266397dc1732320b527f38c48f883
https://doi.org/10.1101/2023.03.30.534899
https://doi.org/10.1101/2023.03.30.534899
Publikováno v:
J Biol Chem
Carnosine (β-alanyl-l-histidine) and anserine (β-alanyl-3-methyl-l-histidine) are abundant peptides in the nervous system and skeletal muscle of many vertebrates. Many in vitro and in vivo studies demonstrated that exogenously added carnosine can i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedcda4bcb290f7e6c72aad9036f344d
https://doi.org/10.1074/jbc.ra120.014188
https://doi.org/10.1074/jbc.ra120.014188
Autor:
Silvia Jordans, Matthias Eckhardt, Dominic Winter, Robert Hardt, Lihua Wang-Eckhardt, Volkmar Gieselmann
Publikováno v:
Human Molecular Genetics. 29:3616-3630
Spastic paraplegia 35 (SPG35) (OMIM: 612319) or fatty acid hydroxylase-associated neurodegeneration (FAHN) is caused by deficiency of fatty acid 2-hydroxylase (FA2H). This enzyme synthesizes sphingolipids containing 2-hydroxylated fatty acids, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704c6abee7fbef6afad920ae79f1194c
https://doi.org/10.1093/hmg/ddaa246
https://doi.org/10.1093/hmg/ddaa246
Autor:
Ivonne Becker, Matthias Eckhardt
Publikováno v:
Analytical Biochemistry. 667:115083
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe8213cb0ca9e8f6ea4d400042d6b9de
https://doi.org/10.1016/j.ab.2023.115083
https://doi.org/10.1016/j.ab.2023.115083
Autor:
Matthias Eckhardt
Publikováno v:
International Journal of Molecular Sciences. 24:4908
Sphingolipids containing acyl residues that are hydroxylated at C-2 are found in most, if not all, eukaryotes and certain bacteria. 2-hydroxylated sphingolipids are present in many organs and cell types, though they are especially abundant in myelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3e580ffcd93382a8fca863722a74d25
https://doi.org/10.3390/ijms24054908
https://doi.org/10.3390/ijms24054908
Autor:
Wanda M. Gerding, Marco Tembrink, Verena Nilius‐Eliliwi, Thomas Mika, Fotios Dimopoulos, Swetlana Ladigan‐Badura, Matthias Eckhardt, Michael Pohl, Max Wünnenberg, Pakhshan Farshi, Peter Reimer, Roland Schroers, Huu Phuc Nguyen, Deepak B. Vangala
Publikováno v:
International journal of cancerREFERENCES. 150(12)
Cytogenetic diagnostics play a crucial role in risk stratification and classification of myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), thus influencing treatment decisions. Optical genome mapping (OGM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd1e3a5977a604d0d4ae8037a2819f2
https://pubmed.ncbi.nlm.nih.gov/35064925
https://pubmed.ncbi.nlm.nih.gov/35064925