Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Matthew Zawistowski"'
Autor:
César Higgins Tejera, Erin B. Ware, Margaret T. Hicken, Lindsay C. Kobayashi, Herong Wang, Freida Blostein, Matthew Zawistowski, Bhramar Mukherjee, Kelly M. Bakulski
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024)
Abstract Background Exposure to systemic racism is linked to increased dementia burden. To assess systemic inflammation as a potential pathway linking exposure to racism and dementia disparities, we investigated the mediating role of C-reactive prote
Externí odkaz:
https://doaj.org/article/5c4f1c12927542f38bae1ae2efc8f4f7
Autor:
Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson, Jacy Zanussi, Laura L. Daniel, Neil S. Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P. Jarvik, Elisabeth A. Rosenthal, Atlas Khan, Alborz Sherafati, Iftikhar J. Kullo, Theresa L. Walunas, Joseph Glessner, Hakon Hakonarson, Nancy J. Cox, Dan M. Roden, Stephan G. Frangakis, Brett Vanderwerff, C. Michael Stein, Sara L. Van Driest, Scott C. Borinstein, Xiao-Ou Shu, Matthew Zawistowski, Cecilia P. Chung, Vivian K. Kawai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical consequences of a genetic predisposit
Externí odkaz:
https://doaj.org/article/aac9cb1b2aa64c909fbdd66e307ed326
Autor:
Kyle A. Campbell, Mingzhou Fu, Elizabeth MacDonald, Matthew Zawistowski, Kelly M. Bakulski, Erin B. Ware
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION In observational studies, the association between alcohol consumption and dementia is mixed. METHODS We performed two‐sample Mendelian randomization (MR) using summary statistics from genome‐wide association studies of weekl
Externí odkaz:
https://doaj.org/article/a6ae55459d0a42f0852e33fff11bd539
Autor:
Allison Reiner, Kelly M. Bakulski, Jonah D. Fisher, John F Dou, Lisa Schneper, Colter Mitchell, Daniel A. Notterman, Matthew Zawistowski, Erin B. Ware
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
The prevalence and severity of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue but are not well stu
Externí odkaz:
https://doaj.org/article/f8c8a016d4844733a5bd7e324d0e2d75
Autor:
Daniel B. Larach, Adam Lewis, Lisa Bastarache, Anita Pandit, Jing He, Anik Sinha, Nicholas J. Douville, Michael Heung, Michael R. Mathis, Jonathan D. Mosley, Jonathan P. Wanderer, Sachin Kheterpal, Matthew Zawistowski, Chad M. Brummett, Edward D. Siew, Cassianne Robinson-Cohen, Miklos D. Kertai
Publikováno v:
BMC Nephrology, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Prior studies support a genetic basis for postoperative acute kidney injury (AKI). We conducted a genome-wide association study (GWAS), assessed the clinical utility of a polygenic risk score (PRS), and estimated the heritable com
Externí odkaz:
https://doaj.org/article/813edc1012fa4c88a501d1fbf8d0c6be
Autor:
César Higgins Tejera, Erin B. Ware, Lindsay C. Kobayashi, Mingzhou Fu, Margaret Hicken, Matthew Zawistowski, Bhramar Mukherjee, Kelly M. Bakulski
Publikováno v:
Frontiers in Human Neuroscience, Vol 17 (2023)
Background and objectivesElevated circulating cystatin C is associated with cognitive impairment in non-Hispanic Whites, but its role in racial disparities in dementia is understudied. In a nationally representative sample of older non-Hispanic White
Externí odkaz:
https://doaj.org/article/53d2ef0b6b9a49e38c268a2701b4480f
Autor:
Matthew Zawistowski, Lars G. Fritsche, Anita Pandit, Brett Vanderwerff, Snehal Patil, Ellen M. Schmidt, Peter VandeHaar, Cristen J. Willer, Chad M. Brummett, Sachin Kheterpal, Xiang Zhou, Michael Boehnke, Gonçalo R. Abecasis, Sebastian Zöllner
Publikováno v:
Cell Genomics, Vol 3, Iss 2, Pp 100257- (2023)
Summary: Biobanks of linked clinical patient histories and biological samples are an efficient strategy to generate large cohorts for modern genetics research. Biobank recruitment varies by factors such as geographic catchment and sampling strategy,
Externí odkaz:
https://doaj.org/article/a1ae3f1dd1614819be1de45156e83e65
Autor:
Ying Wang, Shinichi Namba, Esteban Lopera, Sini Kerminen, Kristin Tsuo, Kristi Läll, Masahiro Kanai, Wei Zhou, Kuan-Han Wu, Marie-Julie Favé, Laxmi Bhatta, Philip Awadalla, Ben Brumpton, Patrick Deelen, Kristian Hveem, Valeria Lo Faro, Reedik Mägi, Yoshinori Murakami, Serena Sanna, Jordan W. Smoller, Jasmina Uzunovic, Brooke N. Wolford, Cristen Willer, Eric R. Gamazon, Nancy J. Cox, Ida Surakka, Yukinori Okada, Alicia R. Martin, Jibril Hirbo, Kuan-Han H. Wu, Humaira Rasheed, Jibril B. Hirbo, Arjun Bhattacharya, Huiling Zhao, Esteban A. Lopera-Maya, Sinéad B. Chapman, Juha Karjalainen, Mitja Kurki, Maasha Mutaamba, Juulia J. Partanen, Ben M. Brumpton, Sameer Chavan, Tzu-Ting Chen, Michelle Daya, Yi Ding, Yen-Chen A. Feng, Christopher R. Gignoux, Sarah E. Graham, Whitney E. Hornsby, Nathan Ingold, Ruth Johnson, Triin Laisk, Kuang Lin, Jun Lv, Iona Y. Millwood, Priit Palta, Anita Pandit, Michael H. Preuss, Unnur Thorsteinsdottir, Matthew Zawistowski, Xue Zhong, Archie Campbell, Kristy Crooks, Geertruida H. de Bock, Nicholas J. Douville, Sarah Finer, Lars G. Fritsche, Christopher J. Griffiths, Yu Guo, Karen A. Hunt, Takahiro Konuma, Riccardo E. Marioni, Jansonius Nomdo, Snehal Patil, Nicholas Rafaels, Anne Richmond, Jonathan A. Shortt, Peter Straub, Ran Tao, Brett Vanderwerff, Kathleen C. Barnes, Marike Boezen, Zhengming Chen, Chia-Yen Chen, Judy Cho, George Davey Smith, Hilary K. Finucane, Lude Franke, Andrea Ganna, Tom R. Gaunt, Tian Ge, Hailiang Huang, Jennifer Huffman, Jukka T. Koskela, Clara Lajonchere, Matthew H. Law, Liming Li, Cecilia M. Lindgren, Ruth J.F. Loos, Stuart MacGregor, Koichi Matsuda, Catherine M. Olsen, David J. Porteous, Jordan A. Shavit, Harold Snieder, Richard C. Trembath, Judith M. Vonk, David Whiteman, Stephen J. Wicks, Cisca Wijmenga, John Wright, Jie Zheng, Xiang Zhou, Michael Boehnke, Daniel H. Geschwind, Caroline Hayward, Eimear E. Kenny, Yen-Feng Lin, Hilary C. Martin, Sarah E. Medland, Aarno V. Palotie, Bogdan Pasaniuc, Kari Stefansson, David A. van Heel, Robin G. Walters, Sebastian Zöllner, Cristen J. Willer, Mark J. Daly, Benjamin M. Neale
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100241- (2023)
Summary: Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data from Global Biobank M
Externí odkaz:
https://doaj.org/article/ab70f310dfdd4e7dbc3dc7fc2ba9b939
Autor:
Adrien Georges, Min-Lee Yang, Takiy-Eddine Berrandou, Mark K. Bakker, Ozan Dikilitas, Soto Romuald Kiando, Lijiang Ma, Benjamin A. Satterfield, Sebanti Sengupta, Mengyao Yu, Jean-François Deleuze, Delia Dupré, Kristina L. Hunker, Sergiy Kyryachenko, Lu Liu, Ines Sayoud-Sadeg, Laurence Amar, Chad M. Brummett, Dawn M. Coleman, Valentina d’Escamard, Peter de Leeuw, Natalia Fendrikova-Mahlay, Daniella Kadian-Dodov, Jun Z. Li, Aurélien Lorthioir, Marco Pappaccogli, Aleksander Prejbisz, Witold Smigielski, James C. Stanley, Matthew Zawistowski, Xiang Zhou, Sebastian Zöllner, FEIRI investigators, International Stroke Genetics Consortium (ISGC) Intracranial Aneurysm Working Group, MEGASTROKE, Philippe Amouyel, Marc L. De Buyzere, Stéphanie Debette, Piotr Dobrowolski, Wojciech Drygas, Heather L. Gornik, Jeffrey W. Olin, Jerzy Piwonski, Ernst R. Rietzschel, Ynte M. Ruigrok, Miikka Vikkula, Ewa Warchol Celinska, Andrzej Januszewicz, Iftikhar J. Kullo, Michel Azizi, Xavier Jeunemaitre, Alexandre Persu, Jason C. Kovacic, Santhi K. Ganesh, Nabila Bouatia-Naji
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Fibromuscular dysplasia is a cardiovascular disease affecting mostly women with a mostly unknown genetic basis. Here the authors have performed a genome-wide association meta-analysis of Fibromuscular dysplasia to identify genetic loci, some of which
Externí odkaz:
https://doaj.org/article/1ca76cab0eb244289d31e35f5458c7b3
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease
Autor:
Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Nicholette D. Palmer, Yii-Der Chen, Seung H. Choi, Steven A. Lubitz, Patrick T. Ellinor, Kathleen C. Barnes, Michelle Daya, Nicholas Rafaels, Scott T. Weiss, Jessica Lasky-Su, Russell P. Tracy, Ramachandran S. Vasan, L. Adrienne Cupples, Rasika A. Mathias, Lisa R. Yanek, Lewis C. Becker, Patricia A. Peyser, Lawrence F. Bielak, Jennifer A. Smith, Stella Aslibekyan, Bertha A. Hidalgo, Donna K. Arnett, Marguerite R. Irvin, James G. Wilson, Solomon K. Musani, Adolfo Correa, Stephen S. Rich, Xiuqing Guo, Jerome I. Rotter, Barbara A. Konkle, Jill M. Johnsen, Allison E. Ashley-Koch, Marilyn J. Telen, Vivien A. Sheehan, John Blangero, Joanne E. Curran, Juan M. Peralta, Courtney Montgomery, Wayne H-H Sheu, Ren-Hua Chung, Karen Schwander, Seyed M. Nouraie, Victor R. Gordeuk, Yingze Zhang, Charles Kooperberg, Alexander P. Reiner, Rebecca D. Jackson, Eugene R. Bleecker, Deborah A. Meyers, Xingnan Li, Sayantan Das, Ketian Yu, Jonathon LeFaive, Albert Smith, Tom Blackwell, Daniel Taliun, Sebastian Zollner, Lukas Forer, Sebastian Schoenherr, Christian Fuchsberger, Anita Pandit, Matthew Zawistowski, Sachin Kheterpal, Chad M. Brummett, Pradeep Natarajan, David Schlessinger, Seunggeun Lee, Hyun Min Kang, Francesco Cucca, Oddgeir L. Holmen, Bjørn O. Åsvold, Michael Boehnke, Sekar Kathiresan, Goncalo R. Abecasis, Y. Eugene Chen, Cristen J. Willer, Kristian Hveem
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Drugs targeting cardiovascular disease (CVD) can have negative consequences for liver function. Here, the authors combine genome wide analyses on 69,479 individuals to identify loss-of-function variants with beneficial effects on CVD-related traits w
Externí odkaz:
https://doaj.org/article/2eecf9230b454b46b95b45b0f20ddd2e