Výsledky vyhledávání - "Matthew Wolfgang Jaeschke"

Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole

Autor: Jephte Yao Akakpo, Matthew Wolfgang Jaeschke, Yasaman Etemadi, Antonio Artigues, Scott Toerber, Hernando Olivos, Bindesh Shrestha, Anthony Midey, Hartmut Jaeschke, Anup Ramachandran

Publikováno v: Journal of the American Society for Mass Spectrometry. 33(11)

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US, and hepatotoxicity is initiated by a reactive metabolite which induces characteristic centrilobular necrosis. The only clinically available antidote is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8633d243d4f5dcbe9c6add284e6ec4d4
https://pubmed.ncbi.nlm.nih.gov/36223142

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