Výsledky vyhledávání - "Matthew Wigan"

Defective Decatenation Checkpoint Function Is a Common Feature of Melanoma

Autor: Kee Ming Chia, Brian Gabrielli, Sandra Pavey, Mitchell S. Stark, Kelly Brooks, Loredana Spoerri, Matthew Wigan, Pamela Mukhopadhyay

Publikováno v: Journal of Investigative Dermatology. 134(1):150-158

A hallmark of cancer is genomic instability that is considered to provide the adaptive capacity of cancers to thrive under conditions in which the normal precursors would not survive. Recent genomic analysis has revealed a very high degree of genomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86226c6af3ee50c7360f3240a52ab66d

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A UVR-Induced G2-Phase Checkpoint Response to ssDNA Gaps Produced by Replication Fork Bypass of Unrepaired Lesions Is Defective in Melanoma

Autor: Andrew Burgess, ShuShyan Wong, Brian Gabrielli, Sandra Pavey, Nichole Giles, Alex Pinder, Matthew Wigan, Richard A. Sturm

Publikováno v: Journal of Investigative Dermatology. 132:1681-1688

UVR is a major environmental risk factor for the development of melanoma. Here we describe a coupled DNA-damage tolerance (DDT) mechanism and G2-phase cell cycle checkpoint induced in response to suberythemal doses of UVR that is commonly defective i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46a4ea1406f32f23a808888034b7e7c
https://doi.org/10.1038/jid.2012.41

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Abstract A65: Targeting the defective decatenation checkpoint in melanoma

Autor: Nicole Giles, Brian Gabrielli, Pamela Mukhopadhyay, Matthew Wigan, Max V. Ranall, Kelly Brooks, Sandra Pavey

Publikováno v: Molecular Cancer Therapeutics. 10:A65-A65

In Australia melanomas account for 10% of all reported cancers and 3% of cancer mortalities. Current treatments offer Using ICRF-193, an inhibitor of Topoisomerase II, a panel of melanoma cell lines were investigated for decatenation checkpoint funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21604f27abeb50e69173efb3148aef59
https://doi.org/10.1158/1535-7163.targ-11-a65

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Abstract 4197: A DNA damage checkpoint response to unrepaired ultraviolet radiation-induced lesions which is defective in melanoma

Autor: Brian Gabrielli, Kelly Brooks, Matthew Wigan, Richard A. Sturm, Andrew Burgess, Nichole Giles, Sandra Pavey

Publikováno v: Cancer Research. 71:4197-4197

Ultraviolet radiation (UVR) is a major environmental risk factor in the development of skin cancer. Here we describe a G2 phase cell cycle checkpoint response to suberythemal doses of UVR that is defective in a majority of melanoma cell lines tested.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d88713ea861d7bae1d381c324d3675a8
https://doi.org/10.1158/1538-7445.am2011-4197

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Inhibition of S/G2 phase CDK4 reduces mitotic fidelity

Autor: Nichole Giles, Brian Gabrielli, Wanda DePinto, Andrew Burgess, Matthew Wigan, Paul Gillespie, Frankie Stevens

Publikováno v: Melanoma Research. 16:S5

Cyclin-dependent kinase 4 (CDK4)/cyclin D has a key role in regulating progression through late G(1) into S phase of the cell cycle. CDK4-cyclin D complexes then persist through the latter phases of the cell cycle, although little is known about thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80181f146d5246d4fb8f5f6b20ef5a8
https://doi.org/10.1097/00008390-200609001-00006

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