Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Matthew Whitman"'
Autor:
Yaara Zwang, Oliver Jonas, Casandra Chen, Mikael L Rinne, John G Doench, Federica Piccioni, Li Tan, Hai-Tsang Huang, Jinhua Wang, Young Jin Ham, Joyce O'Connell, Patrick Bhola, Mihir Doshi, Matthew Whitman, Michael Cima, Anthony Letai, David E Root, Robert S Langer, Nathanael Gray, William C Hahn
Publikováno v:
eLife, Vol 6 (2017)
Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for gen
Externí odkaz:
https://doaj.org/article/e53a69f812244f4b946e1569b458a6f8
Autor:
Pei Zhou, Nimrat Chatterjee, Sophia M Min, Oliver Jonas, Graham C. Walker, Michael T. Hemann, Matthew G. Vander Heiden, Evan C. Lien, Matthew Whitman, Cynthia A. Harris, Alba Luengo, Jiyong Hong
Publikováno v:
Proc Natl Acad Sci U S A
REV1/POLζ-dependent mutagenic translesion synthesis (TLS) promotes cell survival after DNA damage but is responsible for most of the resulting mutations. A novel inhibitor of this pathway, JH-RE-06, promotes cisplatin efficacy in cancer cells and mo
Publikováno v:
Clinical Cancer Research. 24:5458-5470
Purpose: Clinically available BH3 mimetic drugs targeting BCLXL and/or BCL2 (navitoclax and venetoclax, respectively) are effective in some hematologic malignancies, but have limited efficacy in solid tumors. This study aimed to identify combination
Despite significant research into the mechanisms underlying cancer, clinical progress has been limited. This discrepancy is possibly due to a lack of model systems that allow studying tumor development and therapy responses under relevant microenviro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6944bd567f1ec1579a79df3af4354f6
https://doi.org/10.1016/b978-0-12-816137-1.00077-5
https://doi.org/10.1016/b978-0-12-816137-1.00077-5
Autor:
Matthew Whitman, Sen Chen, Shohreh Varmeh, Michel O. Steinmetz, Oliver Jonas, Douglas A. Lauffenburger, Tobias Mühlethaler, Andrea E. Prota, Brian A. Joughin, Michael B. Yaffe, Steven P. Balk, Jesse C. Patterson
Publikováno v:
Cell Syst
There is an unmet need for new antimitotic drug combinations that target cancer-specific vulnerabilities. Based on our finding of elevated biomolecule oxidation in mitotically arrested cancer cells, we combined Plk1 inhibitors with TH588, an MTH1 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c8ae9ec92afe962d0759dfc8ddfb0f
https://europepmc.org/articles/PMC6688637/
https://europepmc.org/articles/PMC6688637/
Autor:
Joyce T. O’Connell, Nathanael S. Gray, Casandra Chen, Oliver Jonas, John G. Doench, Mihir B. Doshi, Li Tan, Michael J. Cima, Matthew Whitman, William C. Hahn, Federica Piccioni, Robert Langer, Mikael L. Rinne, Jinhua Wang, Young Jin Ham, David E. Root, Yaara Zwang, Anthony Letai, Patrick Bhola, Hai-Tsang Huang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570c751fe20de259894fc30b16fe8035
https://doi.org/10.7554/elife.24523.023
https://doi.org/10.7554/elife.24523.023
Autor:
Matthew Whitman, Joyce T. O’Connell, Mihir B. Doshi, Patrick Bhola, Li Tan, Jinhua Wang, Robert Langer, Anthony Letai, Oliver Jonas, Young Jin Ham, John G. Doench, Yaara Zwang, William C. Hahn, Casandra Chen, David E. Root, Nathanael S. Gray, Federica Piccioni, Mikael L. Rinne, Hai-Tsang Huang, Michael J. Cima
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for gen
Autor:
Joshua D. Rabinowitz, Alex Lammers, Alba Luengo, Kendall J. Condon, Jongyoon Han, Dafna Bar-Sagi, Jeffrey Wyckoff, Michael J. Cima, Robert Langer, Katherine A Kellersberger, Christopher R. Chin, Brian K Stall, Shawn M. Davidson, Jared R. Mayers, Mark A. Keibler, Han Wei Hou, Oliver Jonas, Matthew Whitman, Gregory Stephanopoulos, Amanda M. Del Rosario, Matthew G. Vander Heiden
Publikováno v:
PMC
Mammalian tissues rely on a variety of nutrients to support their physiological functions. It is known that altered metabolism is involved in the pathogenesis of cancer, but which nutrients support the inappropriate growth of intact malignant tumors
Autor:
David Kilburn, Mark A. Dane, James E. Korkola, Wallace Thompson, Tiera Liby, Joe W. Gray, Gordon B. Mills, Laura M. Heiser, Moqing Liu, Michel Nederlof, Rebecca Smith, Damir Sudar, Elmar Bucher, Koei Chin, S. Watson, Oliver Jonas, Zuzana Tatarova, Matthew Whitman
Publikováno v:
Cell systems
SUMMARY Extrinsic signals are implicated in breast cancer resistance to HER2-targeted tyrosine kinase inhibitors (TKIs). To examine how microenvironmental signals influence resistance, we monitored TKI-treated breast cancer cell lines grown on microe
Publikováno v:
Proceedings of the National Academy of Sciences. 83:8492-8495
Rat thoracic aortic smooth muscle cells (line A10, ATCC CRL 1476) display a high density of atrial natriuretic factor (ANF) receptors. ANF stimulated the accumulation of cGMP in these cells in a time- and dose-dependent fashion. These cells are known