Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Matthew W. Haley"'
Autor:
Cong Bi, James Chadwick, Merrill L. Davies, Albert J. DelMonte, Peng Geng, Andrew W. Glace, Rebecca A. Green, John A. Gurak, Matthew W. Haley, Brian L. He, Bahar Inankur, Christopher R. Jamison, Candice L. Joe, Sergei Kolotuchin, Dong Lin, Sha Lou, Jeffrey Nye, Adrian Ortiz, Geoffrey E. Purdum, Victor W. Rosso, Mansi Shah, Eric M. Simmons, Jason M. Stevens, Neil A. Strotman, Yichen Tan, Ling Zhang
Publikováno v:
The Journal of organic chemistry.
The development of a convergent route to the NLRP3 (nucleotide-binding domain and leucine-rich repeat-containing protein 3) agonist BMS-986299 is reported. The synthesis relies on a key Miyaura borylation and a tandem Suzuki-Miyaura coupling between
Autor:
Manjunath Gujjar, Subha Mukherjee, Souvik Rakshit, Jamison Christopher Robert, Matthew W. Haley, Chris Sfouggatakis, Matthew J. Goldfogel, Rajappa Vaidyanathan, Scott A. Savage, Jayaraj Mohan
Publikováno v:
Organic Process Research & Development. 26:624-634
The development and implementation of two process syntheses to provide BMS-986224, an agonist of the APJ receptor, are reported. The first-generation synthesis of BMS-986224 relied on a key enamine...
Autor:
Yichen Tan, Yu Fan, Matthew R. Hickey, Michael A. Schmidt, Christopher Wilbert, Darryl D. Dixon, Vidya Iyer, Fanfair Dayne Dustan, Benjamin M. Cohen, Matthew W. Haley, Jason M. Stevens, Miao Yu, Kenneth J. Fraunhoffer, Andrew W. Glace, Adam Joseph Freitag, Kathryn Camacho, Francisco González-Bobes, Michael S. Bultman, Victor W. Rosso, Jeanne Ho, Ian S. Young, Albert J. DelMonte, Prantik Maity, Manjunath Gujjar, Gregory L. Beutner, Sunil S. Patel
Publikováno v:
Organic Process Research & Development. 23:2482-2498
The process development and the kilogram-scale synthesis of linrodostat (BMS-986205, 1) are described. The synthesis features several highly efficient telescoped processes and the use of Evans auxi...
Publikováno v:
Tetrahedron Letters. 59:2664-2667
Over-alkylation side products are common in the alkylation of amines by substitution. In the synthesis of the novel HIV Maturation inhibitor BMS-955176, two over-alkylation byproducts were routinely observed at the penultimate synthetic step, in whic
Autor:
Jonas F. Buergler, John L. Wood, Yutaka Kobayashi, Matthew W. Haley, Koichi Fujiwara, Travis C. McMahon, Jennifer M. Howell, Heemal H. Dhanjee
Publikováno v:
Tetrahedron. 72:3673-3677
Efforts to install the core azepine ring in tetrapetalone A via a palladium π-allyl cascade reaction failed due to competing pathways that included an unexpected and interesting TMM-like cycloaddition reaction that delivers a complex tricyclic ring
Autor:
Tamas Benkovics, Maxime Soumeillant, Susanne Kiau, Neil A. Strotman, Adrian Ortiz, Jeffrey Nye, Yichen Tan, Sloan Ayers, Scott A. Savage, Zhongmin Xu, Matthew W. Haley, Qi Gao
Publikováno v:
The Journal of organic chemistry. 82(9)
A concise and scalable second generation synthesis of HIV maturation inhibitor BMS-955176 is described. The synthesis is framed by an oxidation strategy highlighted by a CuI mediated aerobic oxidation of betulin, a highly selective PIFA mediated dehy
Autor:
Steven Tymonko, Ronald L. Hanson, Matthew W. Haley, Annie Tam, Animesh Goswami, Zhongmin Xu, Ian S. Young
Publikováno v:
Organic Process Research & Development. 19:1360-1368
A scalable synthesis of (R,R)-2,6-dimethyldihydro-2H-pyran-4(3H)-one is reported. Key to this strategy is the Ti(OiPr)4-catalyzed Kulinkovich cyclopropanation of silyl protected (R)-ethyl 3-hydroxybutanoate, and subsequent oxidative fragmentation of
Autor:
Ronald L. Hanson, Animesh Goswami, Zhongmin Xu, Matthew W. Haley, Annie Tam, Ian S. Young, Steven Tymonko
Publikováno v:
ChemInform. 47
Key step of the improved synthesis of title compound (VIII) is the Kulinkovich cyclopropanation, and subsequent oxidative fragmentation of the cyclopropanol (IV).
Publikováno v:
Organic Letters. 13:4712-4715
The formal synthesis of (+)-sorangicin A was completed by two independent routes. Both approaches feature a cross metathesis reaction to form the C29-C30 bond to arrive at the bicyclic ether/tetrahydropyran fragment. Formation of the C15-C16 olefin t
Autor:
Matthew W. Haley, Michael T. Crimmins
Publikováno v:
Organic Letters. 8:4223-4225
Construction of the unique bicyclic bis-ether core of the macrolide (+)-sorangicin A has been achieved. This fragment was prepared by utilizing a one-pot cascade of three bond forming events. An epoxide opening of the epoxy tosylate 2 led to the form