Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Matthew W Frank"'
Autor:
Haley Echlin, Matthew W Frank, Amy Iverson, Ti-Cheng Chang, Michael D L Johnson, Charles O Rock, Jason W Rosch
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005951 (2016)
The pneumococcus is one of the most prodigious producers of hydrogen peroxide amongst bacterial pathogens. Hydrogen peroxide production by the pneumococcus has been implicated in antibiotic synergism, competition between other bacterial colonizers of
Externí odkaz:
https://doaj.org/article/ffeece64e7d94d6f8aead0dd2553d91f
Autor:
Christopher D. Radka, Matthew W. Frank, Tyler S. Simmons, Cydney N. Johnson, Jason W. Rosch, Charles O. Rock
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Commensal gut bacteria use oleate hydratase to release a spectrum of hydroxylated fatty acids using host-derived unsaturated fatty acids. These compounds are thought to attenuate the immune response, but the underlying signaling mechanism(s) remain t
Externí odkaz:
https://doaj.org/article/70f3502acdec48fe9505c1796b4179e0
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT Phosphatidylglycerol (PG) is the major membrane phospholipid of Staphylococcus aureus and predominately consists of molecular species with ≥16-carbon acyl chains in the 1-position and anteiso 12(S)-methyltetradecaonate (a15) esterified at
Externí odkaz:
https://doaj.org/article/cf3a8033dac5423f97d3bcf2bd7e73c2
Autor:
Chitra Subramanian, Matthew W. Frank, Rajendra Tangallapally, Mi‐Kyung Yun, Stephen W. White, Richard E. Lee, Charles O. Rock, Suzanne Jackowski
Publikováno v:
Journal of Inherited Metabolic Disease. 46:28-42
Propionic acidemia (PA, OMIM 606054) is a devastating inborn error of metabolism arising from mutations that reduce the activity of the mitochondrial enzyme propionyl-CoA carboxylase (PCC). The defects in PCC reduce the concentrations of nonesterifie
Publikováno v:
mSphere. 8
Glycerol ester hydrolase, Geh, is an abundant secreted lipase whose expression is controlled by the accessory gene regulator (Agr) quorum-sensing signal transduction pathway. Geh is thought to have a role in virulence based on its ability to hydrolyz
Publikováno v:
The Journal of biological chemistry. 298(8)
Sulfonolipids are unusual lipids found in the outer membranes of Gram-negative bacteria in the phylum Bacteroidetes. Sulfonolipid and its deacylated derivative, capnine, are sulfur analogs of ceramide-1-phosphate and sphingosine-1-phosphate, respecti
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Mol Microbiol
Streptococcus pneumoniae is a major human pathogen that must adapt to unique nutritional environments in several host niches. The pneumococcus can metabolize a range of carbohydrates that feed into glycolysis ending in pyruvate, which is catabolized
Publikováno v:
Mol Microbiol
Members of the Bacteroidetes phylum, represented by Alistipes finegoldii, are prominent anerobic, Gram-negative inhabitants of the gut microbiome. The lipid biosynthetic pathways were analyzed using bioinformatic analyses, lipidomics, metabolic label
Publikováno v:
Journal of Biological Chemistry. 294:16416-16428
Streptococcus pneumoniae is responsible for the majority of pneumonia, motivating ongoing searches for insights into its physiology that could enable new treatments. S. pneumoniae responds to exogenous fatty acids by suppressing its de novo biosynthe