Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Matthew W B Trotter"'
Autor:
Samuel A Danziger, Mark McConnell, Jake Gockley, Mary H Young, Adam Rosenthal, Frank Schmitz, David J Reiss, Phil Farmer, Daisy V Alapat, Amrit Singh, Cody Ashby, Michael Bauer, Yan Ren, Kelsie Smith, Suzana S Couto, Frits van Rhee, Faith Davies, Maurizio Zangari, Nathan Petty, Robert Z Orlowski, Madhav V Dhodapkar, Wilbert B Copeland, Brian Fox, Antje Hoering, Alison Fitch, Katie Newhall, Bart Barlogie, Matthew W B Trotter, Robert M Hershberg, Brian A Walker, Andrew P Dervan, Alexander V Ratushny, Gareth J Morgan
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
BackgroundThe tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, wh
Externí odkaz:
https://doaj.org/article/48a59d8f2fb64baa9b747522459ffea9
Autor:
Samuel A Danziger, David L Gibbs, Ilya Shmulevich, Mark McConnell, Matthew W B Trotter, Frank Schmitz, David J Reiss, Alexander V Ratushny
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0224693 (2019)
Immune cell infiltration of tumors and the tumor microenvironment can be an important component for determining patient outcomes. For example, immune and stromal cell presence inferred by deconvolving patient gene expression data may help identify hi
Externí odkaz:
https://doaj.org/article/c210f3640b084ae4b0efafef16177ca4
Autor:
Lisa M Breckels, Sean B Holden, David Wojnar, Claire M Mulvey, Andy Christoforou, Arnoud Groen, Matthew W B Trotter, Oliver Kohlbacher, Kathryn S Lilley, Laurent Gatto
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 5, p e1004920 (2016)
Sub-cellular localisation of proteins is an essential post-translational regulatory mechanism that can be assayed using high-throughput mass spectrometry (MS). These MS-based spatial proteomics experiments enable us to pinpoint the sub-cellular distr
Externí odkaz:
https://doaj.org/article/c25995a02a4b4247953bc222acc05e9e
Publikováno v:
Measurement + Control, Vol 34 (2001)
Externí odkaz:
https://doaj.org/article/4f0075b3066741d99d96fdbfdd2da65a
Autor:
Yasir A. Syed, Alexandra Baer, Matthias P. Hofer, Ginez A. González, Jon Rundle, Szymon Myrta, Jeffrey K. Huang, Chao Zhao, Moritz J. Rossner, Matthew W. B. Trotter, Gert Lubec, Robin J. M. Franklin, Mark R. Kotter
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 12, Pp 1918-1934 (2013)
Abstract The increasing effectiveness of new disease‐modifying drugs that suppress disease activity in multiple sclerosis has opened up opportunities for regenerative medicines that enhance remyelination and potentially slow disease progression. Al
Externí odkaz:
https://doaj.org/article/fd413ed2dcbf4765b03c4362314086e9
Autor:
Roberto A. Abbiati, Michael Pourdehnad, Soraya Carrancio, Daniel W. Pierce, Shailaja Kasibhatla, Mark McConnell, Matthew W. B. Trotter, Remco Loos, Cristina C. Santini, Alexander V. Ratushny
Publikováno v:
AAPS J
Avadomide is a cereblon E3 ligase modulator and a potent antitumor and immunomodulatory agent. Avadomide trials are challenged by neutropenia as a major adverse event and a dose-limiting toxicity. Intermittent dosing schedules supported by preclinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e501adf54365233dcafbe28c58b1227
https://europepmc.org/articles/PMC9172776/
https://europepmc.org/articles/PMC9172776/
Autor:
Matthew W. B. Trotter, Sean B. Holden
Publikováno v:
Quantitative Structure-Active Relationships; Jul2003, Vol. 22 Issue 5, p533, 16p
Autor:
María Ortiz-Estévez, Fadi Towfic, Erin Flynt, Nicholas Stong, In Sock Jang, Kai Wang, Matthew W. B. Trotter, Anjan Thakurta
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background Despite significant therapeutic advances in improving lives of multiple myeloma (MM) patients, it remains mostly incurable, with patients ultimately becoming refractory to therapies. MM is a genetically heterogeneous disease and t
Externí odkaz:
https://doaj.org/article/e346ccc8aa5a40cdb54209d390d619d8
Autor:
Matthew A. Wall, Serdar Turkarslan, Wei-Ju Wu, Samuel A. Danziger, David J. Reiss, Mike J. Mason, Andrew P. Dervan, Matthew W. B. Trotter, Douglas Bassett, Robert M. Hershberg, Adrián López García de Lomana, Alexander V. Ratushny, Nitin S. Baliga
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-15 (2021)
Abstract Despite recent advancements in the treatment of multiple myeloma (MM), nearly all patients ultimately relapse and many become refractory to multiple lines of therapies. Therefore, we not only need the ability to predict which patients are at
Externí odkaz:
https://doaj.org/article/8be0e48133514e37800ac2c098080257
Autor:
Juan P. Romero, María Ortiz-Estévez, Ander Muniategui, Soraya Carrancio, Fernando J. de Miguel, Fernando Carazo, Luis M. Montuenga, Remco Loos, Rubén Pío, Matthew W. B. Trotter, Angel Rubio
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-14 (2018)
Abstract Background RNA-seq is a reference technology for determining alternative splicing at genome-wide level. Exon arrays remain widely used for the analysis of gene expression, but show poor validation rate with regard to splicing events. Commerc
Externí odkaz:
https://doaj.org/article/96012101462441f9aca2d9d4dcdca173