Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Matthew W, Frank"'
Autor:
Christopher D. Radka, Matthew W. Frank, Tyler S. Simmons, Cydney N. Johnson, Jason W. Rosch, Charles O. Rock
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Commensal gut bacteria use oleate hydratase to release a spectrum of hydroxylated fatty acids using host-derived unsaturated fatty acids. These compounds are thought to attenuate the immune response, but the underlying signaling mechanism(s) remain t
Externí odkaz:
https://doaj.org/article/70f3502acdec48fe9505c1796b4179e0
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT Phosphatidylglycerol (PG) is the major membrane phospholipid of Staphylococcus aureus and predominately consists of molecular species with ≥16-carbon acyl chains in the 1-position and anteiso 12(S)-methyltetradecaonate (a15) esterified at
Externí odkaz:
https://doaj.org/article/cf3a8033dac5423f97d3bcf2bd7e73c2
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT Staphylococcus aureus is an important pathogen that relies on a variety of mechanisms to evade and counteract the immune system. We show that S. aureus uses oleate hydratase (OhyA) to convert host cis-9 unsaturated fatty acids to their 10-hy
Externí odkaz:
https://doaj.org/article/47fea363acfc4c50b4eb4236ec194815
Autor:
Matthew W. Frank, Jiangwei Yao, Justin L. Batte, Jessica M. Gullett, Chitra Subramanian, Jason W. Rosch, Charles O. Rock
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Staphylococcus aureus utilizes the fatty acid (FA) kinase system to activate exogenous FAs for membrane synthesis. We developed a lipidomics workflow to determine the membrane phosphatidylglycerol (PG) molecular species synthesized by S. aur
Externí odkaz:
https://doaj.org/article/c0ca964bc43b49d1a868f31ece6173e2
Autor:
Lalit Kumar Sharma, Chitra Subramanian, Mi-Kyung Yun, Matthew W. Frank, Stephen W. White, Charles O. Rock, Richard E. Lee, Suzanne Jackowski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Mutations in pantotenate kinase (PANK) cause neurodegneration. Here the authors carry out achemical screen and identify a PANK activator that is orally available, crosses the blood brain barrierand show that it effecttive in improving pathology and l
Externí odkaz:
https://doaj.org/article/df56f7ef021a4881aab28f7777533ce7
Autor:
Chitra Subramanian, Matthew W. Frank, Rajendra Tangallapally, Mi‐Kyung Yun, Stephen W. White, Richard E. Lee, Charles O. Rock, Suzanne Jackowski
Publikováno v:
Journal of Inherited Metabolic Disease. 46:28-42
Propionic acidemia (PA, OMIM 606054) is a devastating inborn error of metabolism arising from mutations that reduce the activity of the mitochondrial enzyme propionyl-CoA carboxylase (PCC). The defects in PCC reduce the concentrations of nonesterifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721ec1eb6bbbf32462630ec85f73f16c
https://doi.org/10.1002/jimd.12570
https://doi.org/10.1002/jimd.12570
Autor:
Angela M. Arensdorf, Miriam E. Dillard, Jacob M. Menke, Matthew W. Frank, Charles O. Rock, Stacey K. Ogden
Publikováno v:
Cell Reports, Vol 19, Iss 10, Pp 2074-2087 (2017)
The G protein-coupled receptor Smoothened (Smo) is the signal transducer of the Sonic Hedgehog (Shh) pathway. Smo signals through G protein-dependent and -independent routes, with G protein-independent canonical signaling to Gli effectors requiring S
Externí odkaz:
https://doaj.org/article/b86b6f142827478da70fd3082ded0c9a
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT The SaeRS two-component system is a master activator of virulence factor transcription in Staphylococcus aureus, but the cellular factors that control its activity are unknown. Fatty acid (FA) kinase is a two-component enzyme system required
Externí odkaz:
https://doaj.org/article/1791429d5b0143d89a786bd6199ca655
Publikováno v:
The Journal of biological chemistry. 298(8)
Sulfonolipids are unusual lipids found in the outer membranes of Gram-negative bacteria in the phylum Bacteroidetes. Sulfonolipid and its deacylated derivative, capnine, are sulfur analogs of ceramide-1-phosphate and sphingosine-1-phosphate, respecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2739de41a5c7861e67a80188e728d499
https://pubmed.ncbi.nlm.nih.gov/35760102
https://pubmed.ncbi.nlm.nih.gov/35760102
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef758924c387a4c9495bee7a5b988d55
https://doi.org/10.1096/fasebj.2022.36.s1.r4125
https://doi.org/10.1096/fasebj.2022.36.s1.r4125