Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Matthew Ulgherait"'
Autor:
Samantha J. Tener, Zhi Lin, Scarlet J. Park, Kairaluchi Oraedu, Matthew Ulgherait, Emily Van Beek, Andrés Martínez-Muñiz, Meghan Pantalia, Jared A. Gatto, Julia Volpi, Nicholas Stavropoulos, William W. Ja, Julie C. Canman, Mimi Shirasu-Hiza
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Mutations in Cullin-3 (Cul3), a conserved gene encoding a ubiquitin ligase, are strongly associated with autism spectrum disorder (ASD). Here, we characterize ASD-related pathologies caused by neuron-specific Cul3 knockdown in Drosophila. We
Externí odkaz:
https://doaj.org/article/0395efbca1cc46338d7654c16c827527
Autor:
Meghan Pantalia, Zhi Lin, Samantha J. Tener, Bing Qiao, Grace Tang, Matthew Ulgherait, Reed O’Connor, Rebecca Delventhal, Julia Volpi, Sheyum Syed, Nissim Itzhak, Julie C. Canman, María Paz Fernández, Mimi Shirasu-Hiza
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Inhibitors of enzymes that inactivate amine neurotransmitters (dopamine, serotonin), such as catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO), are thought to increase neurotransmitter levels and are widely used to treat Parkin
Externí odkaz:
https://doaj.org/article/d180aa0cd77f49c29ae5fac5c35183ba
Autor:
Rebecca Delventhal, Emily R. Wooder, Maylis Basturk, Mohima Sattar, Jonathan Lai, Danielle Bolton, Gayathri Muthukumar, Matthew Ulgherait, Mimi M. Shirasu-Hiza
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Traumatic brain injury (TBI) affects millions annually and is associated with long-term health decline. TBI also shares molecular and cellular hallmarks with neurodegenerative diseases (NDs), typically increasing in prevalence with age, and
Externí odkaz:
https://doaj.org/article/cd80ae0874954609a0ae7ca3935e1eac
Autor:
Anna M. Salazar, Martin Resnik-Docampo, Matthew Ulgherait, Rebecca I. Clark, Mimi Shirasu-Hiza, D. Leanne Jones, David W. Walker
Publikováno v:
iScience, Vol 9, Iss , Pp 229-243 (2018)
Summary: Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intesti
Externí odkaz:
https://doaj.org/article/c6b56f09d47448789766f9856baeeb46
Autor:
Rebecca Delventhal, Reed M O'Connor, Meghan M Pantalia, Matthew Ulgherait, Han X Kim, Maylis K Basturk, Julie C Canman, Mimi Shirasu-Hiza
Publikováno v:
eLife, Vol 8 (2019)
In Drosophila, ~150 neurons expressing molecular clock proteins regulate circadian behavior. Sixteen of these neurons secrete the neuropeptide Pdf and have been called ‘master pacemakers’ because they are essential for circadian rhythms. A subset
Externí odkaz:
https://doaj.org/article/bc7e0b4937834d64871be6d898373b6b
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1767-1780 (2014)
AMPK exerts prolongevity effects in diverse species; however, the tissue-specific mechanisms involved are poorly understood. Here, we show that upregulation of AMPK in the adult Drosophila nervous system induces autophagy both in the brain and also i
Externí odkaz:
https://doaj.org/article/c7fba0051c394a49954f99a977597cfd
Autor:
Martin Resnik-Docampo, Matthew Ulgherait, David W. Walker, Mimi Shirasu-Hiza, D. Leanne Jones, Rebecca I. Clark, Anna M. Salazar
Publikováno v:
iScience, Vol 9, Iss, Pp 229-243 (2018)
iScience
iScience, 2018, Vol.9, pp.229-243 [Peer Reviewed Journal]
iScience
iScience, 2018, Vol.9, pp.229-243 [Peer Reviewed Journal]
Summary Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cfda2249174e043ca839262f4fed87
http://www.sciencedirect.com/science/article/pii/S2589004218301810
http://www.sciencedirect.com/science/article/pii/S2589004218301810
Autor:
Matthew Ulgherait
Publikováno v:
Innovation in Aging
Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show instead that loss of specific circadian clock components Period (Per) and Timeless (Tim) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77b75bc6b54af4fa343021c18b2da976
http://europepmc.org/articles/PMC7743879
http://europepmc.org/articles/PMC7743879
Autor:
Matthew Ulgherait, Mimi Shirasu-Hiza, Reed M. O’Connor, Maylis K Basturk, Rebecca Delventhal, Meghan M Pantalia, Julie C. Canman, Han X Kim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8535b90b547e5f38dcb4bbd2ece0464d
https://doi.org/10.7554/elife.48308.033
https://doi.org/10.7554/elife.48308.033
Publikováno v:
Protein Science. 21:797-808
DGCR8 (DiGeorge Critical Region 8) is an essential microRNA (miRNA) processing protein that recognizes primary transcripts of miRNAs (pri-miRNAs) and triggers their cleavage by the Drosha nuclease. We previously found that Fe(III) heme binds and acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf2b59c7c4c18779f8e33fde1589b1d
https://doi.org/10.1002/pro.2062
https://doi.org/10.1002/pro.2062