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Click chemistry selectively activates an auristatin protodrug with either intratumoral or systemic tumor-targeting agents

Autor: Jesse M McFarland, Masa Aleckovic, George Coricor, Sangeetha Srinivasan, Matthew Tso, John Lee, Tri-Hung Nguyen, Jose M Mejia Oneto

The Click Activated Protodrugs Against Cancer (CAPACTM) platform enables activation of powerful cancer drugs at tumor sites, maximizing efficacy and minimizing systemic toxicity. CAPAC utilizes a potent click chemistry reaction between tetrazine and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea8400fee1c2192475cd05c97cad3c25
https://doi.org/10.1101/2023.03.28.534625

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953 Treatment with SQ3370, a doxorubicin-based therapeutic, corresponds with immunomodulation of the tumor microenvironment

Autor: Masa Aleckovic, Sangeetha Srinivasan, Jesse McFarland, Leslie Priddy, Matthew Tso, Jose Mejia Oneto

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b3d075f4355b7367397d97e664905e7
https://doi.org/10.1136/jitc-2022-sitc2022.0953

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Abstract 4934: CAPAC: a modular platform that can improve the safety and efficacy of existing cancer therapies

Autor: George Coricor, Jesse M. McFarland, Masa Aleckovic, Sangeetha Srinivasan, John Lee, Leslie Priddy, Matthew Tso, Tri-Hung Nguyen, Jose M. Mejia Oneto

Publikováno v: Cancer Research. 83:4934-4934

Click chemistry is a Nobel Prize winning technology that has been widely used in research across the life sciences. Shasqi’s Click Activated Protodrugs Against Cancer (CAPACTM) platform is pioneering the therapeutic application of click chemistry r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::394ad7fa7096aef28ad450144769c80e
https://doi.org/10.1158/1538-7445.am2023-4934

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Abstract B43: Combining SQ3370, a doxorubicin-based therapeutic, with TLR and STING agonists enhances antitumor effects in murine tumor models

Autor: Masa Aleckovic, Sangeetha Srinivasan, Jesse M McFarland, Leslie Priddy, Matthew Tso, Jose M Mejia Oneto

Publikováno v: Cancer Immunology Research. 10:B43-B43

SQ3370, the lead investigational asset of the CAPACTM (Click Activated Protodrugs Against Cancer) platform, is a therapeutic based on doxorubicin which can induce immunogenic cell death in mouse tumors making it a suitable candidate for combination a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34861fd5b890121aa99ea5de9dd93531
https://doi.org/10.1158/2326-6074.tumimm22-b43

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Abstract A029: SQ3370: CAPAC platform enables tumor-localized therapy and minimizes systemic toxicities

Autor: Jose M. Mejia Oneto, Sangeetha Srinivasan, Jesse M. McFarland, Matthew Tso, Masa Aleckovic

Publikováno v: Clinical Cancer Research. 28:A029-A029

Conventional chemotherapies lack specificity for tumor tissue, have a low therapeutic index, and induce systemic toxicities including cardiomyopathy. SQ3370 utilizes the Click Activated Protodrugs Against Cancer (CAPAC) platform to localize doxorubic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39b6a1f3be0c1bff928741c106ec6e71
https://doi.org/10.1158/1557-3265.sarcomas22-a029

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