Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Matthew Trotter"'
Autor:
Aneta Mikulasova, Cody Ashby, Ruslana G. Tytarenko, Pingping Qu, Adam Rosenthal, Judith A. Dent, Katie R. Ryan, Michael A. Bauer, Christopher P. Wardell, Antje Hoering, Konstantinos Mavrommatis, Matthew Trotter, Shayu Deshpande, Shmuel Yaccoby, Erming Tian, Jonathan Keats, Daniel Auclair, Graham H. Jackson, Faith E. Davies, Anjan Thakurta, Gareth J. Morgan, Brian A. Walker
Publikováno v:
Haematologica, Vol 105, Iss 4 (2020)
MYC is a widely acting transcription factor and its deregulation is a crucial event in many human cancers. MYC is important biologically and clinically in multiple myeloma, but the mechanisms underlying its dysregulation are poorly understood. We sho
Externí odkaz:
https://doaj.org/article/5a3d144402e64ba28314204a68ef38ea
Autor:
Maria Barandalla, Hui Shi, Hui Xiao, Silvia Colleoni, Cesare Galli, Pietro Lio, Matthew Trotter, Giovanna Lazzari
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-16 (2017)
Abstract Background Human embryonic stem cells (hESCs) potentially offer new routes to study, on the basis of the Developmental Origins of Health and Disease (DOHaD) concept, how the maternal environment during pregnancy influences the offspring’s
Externí odkaz:
https://doaj.org/article/9542dcb568e44237bd7be70688463fa2
Autor:
Anna Falk, Philipp Koch, Jaideep Kesavan, Yasuhiro Takashima, Julia Ladewig, Michael Alexander, Ole Wiskow, Jignesh Tailor, Matthew Trotter, Steven Pollard, Austin Smith, Oliver Brüstle
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29597 (2012)
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological disease. In particular, iPSC-derived neural cells permit a direct comparison of disease-re
Externí odkaz:
https://doaj.org/article/457e90b423754c62bf460dbcea8c338e
Autor:
Ludovic Vallier, Thomas Touboul, Zhenzhi Chng, Minodora Brimpari, Nicholas Hannan, Enrique Millan, Lucy E Smithers, Matthew Trotter, Peter Rugg-Gunn, Anne Weber, Roger A Pedersen
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6082 (2009)
Human embryonic stem cells have unique value for regenerative medicine, as they are capable of differentiating into a broad variety of cell types. Therefore, defining the signalling pathways that control early cell fate decisions of pluripotent stem
Externí odkaz:
https://doaj.org/article/ddf01b0a556047b18a18c13ffed40993
Autor:
Brian S. White, Mehmet Kemal Samur, Alexander V. Ratushny, Michael Mason, Gareth J. Morgan, Justin Guinney, Yi Cui, Pieter Sonneveld, Bailiang Li, Carolina Schinke, Fadi Towfic, Samuel A. Danziger, Hervé Avet-Loiseau, Matthew Trotter, Elias Chaibub Neto, Hongyue Y Dai, Valeriy V. Lyzogubov, Christine Eng, Jonathan Göke, Anjan Thakurta, Hongjie Chen, Andrew Dervan, William S. Dalton, Daniel Auclair, Douglas Bassett, Nikhil C. Munshi, Kenneth H. Shain, Fred K. Gruber, Boris Hayete, Brian A Walker, Aditya Pratapa, Frank Schmitz, Hartmut Goldschmidt, Thomas Yu, Dirk Hose, Erin Flynt, Kamlesh Bisht, Maria Ortiz, Yuanfang Guan, Konstantinos Mavrommatis, Dan Rozelle
Publikováno v:
Leukemia 34, 1866–1874 (2020)
Leukemia
Leukemia
While the past decade has seen meaningful improvements in clinical outcomes for multiple myeloma patients, a subset of patients do not benefit from current therapeutics for unclear reasons. Many gene expression-based models of risk have been develope
Autor:
Matthew Trotter, Jing Ai, Peter H. Schafer, Matthew E. Stokes, Irina V. Medvedeva, Robert Yang, Dominic Eisinger, Samuel T. Labrie
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Finding biomarkers that provide shared link between disease severity, drug-induced pharmacodynamic effects and response status in human trials can provide number of values for patient benefits: elucidating current therapeutic mechanism-of-action, and
Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Autor:
Hongwei Wang, Matthew Trotter, John C. Obenauer, Michael A Bauer, Kenneth C. Anderson, Brian A Walker, Zhinuan Yu, Pingping Qu, Zhihong Yang, T. Cody Ashby, Erin Flynt, Nikhil C. Munshi, Mariateresa Fulciniti, Mehmet Kemal Samur, A. Keith Stewart, Konstantinos Mavrommatis, Gareth J. Morgan, Dan Rozelle, Antje Hoering, Daniel Auclair, Brian G.M. Durie, Pieter Sonneveld, Hermann Einsele, Adam Rosenthal, Maria Ortiz, Marc S. Raab, Niccolo Bolli, Graham Jackson, Faith E. Davies, Fadi Towfic, Hartmut Goldschmidt, Jonathan J Keats, Christopher P. Wardell, Raphael Szalat, Hervé Avet-Loiseau, Anjan Thakurta, Jesús F. San Miguel, Sagar Lonial, P. Moreau
Publikováno v:
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
Leukemia, 33(1), 159-170. Nature Publishing Group
Leukemia
Oncotarget
instname
Leukemia, 33(1), 159-170. Nature Publishing Group
Leukemia
Oncotarget
Patients with newly diagnosed multiple myeloma (NDMM) with high-risk disease are in need of new treatment strategies to improve the outcomes. Multiple clinical, cytogenetic, or gene expression features have been used to identify high-risk patients, e
Autor:
Mark McConnell, Samuel A. Danziger, Boris Aguilar, David J. Reiss, Matthew Trotter, Alexander V. Ratushny, Andrew Dervan, Robert M. Hershberg, Ilya Shmulevich, Douglas Bassett, David L Gibbs
Publikováno v:
GigaScience
Background Mechanistic models, when combined with pertinent data, can improve our knowledge regarding important molecular and cellular mechanisms found in cancer. These models make the prediction of tissue-level response to drug treatment possible, w
Autor:
Claire Cox, Menon Suraj, Brian Hendrich, Elisabete Nascimento, Duncan T. Odom, Stewart MacArthur, Michaela Frye, Matthew Trotter, Bernd Kübler, Salvador Aznar Benitah, Sandra Blanco, Shobbir Hussain, Jennifer Nichols
Publikováno v:
Nature cell biology
How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation complex, a locus essentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b87e974b3d0685d8efcbed8fd9b025