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Publikováno v:
QJM : monthly journal of the Association of Physicians. 114(11)
Cooperative Effects of Th2 Cytokines and Allergen on Normal and Asthmatic Bronchial Epithelial Cells
Autor:
Fabio Bucchieri, Donna E. Davies, Sarah M. Puddicombe, Susan J. Wilson, James L. Lordan, Athanassias Konstantinidis, Matthew Thornber, Stephen T. Holgate, John W. Holloway, Audrey Richter, Ratko Djukanovic, Diana Buchanan
Publikováno v:
The Journal of Immunology. 169:407-414
In sensitized individuals, exposure to allergens such as Dermatophagoides pteronyssinus (Der p) causes Th2 polarization and release of cytokines, including IL-4 and IL-13. Because Der p extracts also have direct effects on epithelial cells, we hypoth