Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: a prespecified exploratory analysis

Autor: Mills, Nicholas L, Strachan, Fiona E, Tuck, Christopher, Shah, Anoop SV, Anand, Atul, Chapman, Andrew R, Ferry, Amy V, Lee, Kuan Ken, Doudesis, Dimitrios, Bularga, Anda, Wereski, Ryan, Taggart, Caelan, Lowry, Matthew TH, Mendusic, Filip, Kimenai, Dorien M, Sandeman, Dennis, Adamson, Philip D, Stables, Catherine L, Vallejos, Catalina A, Tsanas, Athanasios, Marshall, Lucy, Stewart, Stacey D, Fujisawa, Takeshi, Hautvast, Mischa, McPherson, Jean, McKinlay, Lynn, Ford, Ian, Newby, David E, Fox, Keith AA, Berry, Colin, Walker, Simon, Weir, Christopher J, Gray, Alasdair, Collinson, Paul O, Apple, Fred S, Reid, Alan, Cruikshank, Anne, Findlay, Iain, Amoils, Shannon, McAllister, David A, Maguire, Donogh, Stevens, Jennifer, Norrie, John, Andrews, Jack PM, Moss, Alastair, Anwar, Mohamed S, Hung, John, Malo, Jonathan, Fischbacher, Colin, Croal, Bernard L, Leslie, Stephen J, Keerie, Catriona, Parker, Richard A, Walker, Allan, Harkess, Ronnie, Wackett, Tony, Armstrong, Roma, Stirling, Laura, MacDonald, Claire, Sadat, Imran, Finlay, Frank, Charles, Heather, Linksted, Pamela, Young, Stephen, Alexander, Bill, Duncan, Chris, Yang, Jason, Shah, Anoop S V, Pickering, John W, Than, Martin P

Publikováno v: In The Lancet Digital Health May 2022 4(5):e300-e308

Dynamic reciprocal interactions between activated T cells and tumor associated macrophages drive macrophage reprogramming and proinflammatory T cell migration within prostate tumor models

Autor: Erika Heninger, Matthew Thomas Breneman, Emma Elizabeth Recchia, Sheena Catherine Kerr, Reyna Elvan Dogru, Marina Nasrin Sharifi, Aaron Matthew LeBeau, David Kosoff

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Abstract Tumor-associated macrophages (TAMs) have been implicated as a tumor microenvironment (TME) cell population, which may be playing a vital role in the inhibition of effective T cell responses in the prostate TME. In this manuscript, we leverag

Externí odkaz: https://doaj.org/article/4aa1d1c3b3f343399d371dbd6149337f

Assessment of Oxygen Supply-Demand Imbalance and Outcomes Among Patients With Type 2 Myocardial Infarction: A Secondary Analysis of the High-STEACS Cluster Randomized Clinical Trial

Autor: Bularga, Anda, Taggart, Caelan, Mendusic, Filip, Kimenai, Dorien M, Wereski, Ryan, Lowry, Matthew TH, Lee, Kuan K, Ferry, Amy V, Stewart, Stacey S, McAllister, David A, Shah, Anoop SV, Anand, Atul, Newby, David E, Mills, Nicholas L, Chapman, Andrew R, High-Sensitivity Troponin in the Evaluation of Patients with Sus

Importance: Type 2 myocardial infarction occurs owing to multiple factors associated with myocardial oxygen supply-demand imbalance, which may confer different risks of adverse outcomes. Objective: To evaluate the prevalence and outcomes of different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c7cdcf4c5ef27b021715784f5f9840d8
https://researchonline.lshtm.ac.uk/id/eprint/4666602/1/bularga_2022_oi_220580_1656698674.65915.pdf

Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: a prespecified exploratory analysis

Autor: Dimitrios Doudesis, Kuan Ken Lee, Jason Yang, Ryan Wereski, Anoop S V Shah, Athanasios Tsanas, Atul Anand, John W Pickering, Martin P Than, Nicholas L Mills, Fiona E Strachan, Christopher Tuck, Anoop SV Shah, Andrew R Chapman, Amy V Ferry, Anda Bularga, Caelan Taggart, Matthew TH Lowry, Filip Mendusic, Dorien M Kimenai, Dennis Sandeman, Philip D Adamson, Catherine L Stables, Catalina A Vallejos, Lucy Marshall, Stacey D Stewart, Takeshi Fujisawa, Mischa Hautvast, Jean McPherson, Lynn McKinlay, Ian Ford, David E Newby, Keith AA Fox, Colin Berry, Simon Walker, Christopher J Weir, Alasdair Gray, Paul O Collinson, Fred S Apple, Alan Reid, Anne Cruikshank, Iain Findlay, Shannon Amoils, David A McAllister, Donogh Maguire, Jennifer Stevens, John Norrie, Jack PM Andrews, Alastair Moss, Mohamed S Anwar, John Hung, Jonathan Malo, Colin Fischbacher, Bernard L Croal, Stephen J Leslie, Catriona Keerie, Richard A Parker, Allan Walker, Ronnie Harkess, Tony Wackett, Roma Armstrong, Laura Stirling, Claire MacDonald, Imran Sadat, Frank Finlay, Heather Charles, Pamela Linksted, Stephen Young, Bill Alexander, Chris Duncan

Publikováno v: Doudesis, D, Lee, K K, Yang, J, Wereski, R, Shah, A S, Tsanas, T, Anand, A, Pickering, J W, Than, M P, Mills, N L 2022, ' Validation of the myocardial-ischaemic-injury-index machine learning algorithm to guide the diagnosis of myocardial infarction in a heterogenous population: a prespecified exploratory analysis ', The Lancet Digital Health, pp. e300 . https://doi.org/10.1016/S2589-7500(22)00025-5

Background: We recently introduced the myocardial-ischemic-injury-index (MI3), a machine learning algorithm that predicts the likelihood of myocardial infarction in patients with suspected acute coronary syndrome. Whether this algorithm performs well

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a00d4694c1dd419bf6caed7aa6f061b
https://hdl.handle.net/20.500.11820/2593bf88-bb4b-4cdd-8f04-571d36880916

Toward improving anal health care among GBMSM in Kenya: Lessons from a patient’s illness, treatment and recovery journey

Autor: Samuel Anyula Gorigo, Collins Owek, Zipporah Mwangangi, Harram Memon, Isham Umair, Pascal Macharia, John Mathenge, James Blanchard, Lyle R. McKinnon, Joshua Kimani, Stephen Moses, Parinita Bhattacharjee, Caroline Ngunu-Gituathi, Marissa Becker, Sushena Reza-Paul, Lisa Lazarus, Matthew Thomann, Robert Lorway

Publikováno v: Global Public Health, Vol 19, Iss 1 (2024)

We aimed to illuminate the challenges of treating anal diseases among gay, bisexual and other men who have sex with men (GBMSM) in a homophobic climate amid resource constraints. Building on a long-term Kenyan-Canadian collaboration, an anal healthca

Externí odkaz: https://doaj.org/article/6dc8554f55fd46a480822f5d5d4814a8