Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Matthew T. Tudge"'
Publikováno v:
Organometallics. 40:3599-3607
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16dadf390bba6c1ace1ebfee9b40a6a
https://doi.org/10.1021/acs.organomet.1c00473
https://doi.org/10.1021/acs.organomet.1c00473
Autor:
Matthew T. Tudge, Baoqiang Wan, Edward C. Sherer, Robert A. Reamer, Feng Peng, Zhiguo Jake Song, Lushi Tan, Peter G. Dormer, Amude M. Kassim, John Y. L. Chung, Cheng-yi Chen, Yonggang Chen, Mark G. McLaughlin
Publikováno v:
The Journal of Organic Chemistry. 82:9023-9029
A highly efficient asymmetric synthesis of the key tetrahydropyranol intermediate of DPP-4 inhibitor omarigliptin (1) is described. The successful development of a protecting-group- and precious-metal-free synthesis was achieved via the discovery of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafa49b0870c374b17084bf7666208d7
https://doi.org/10.1021/acs.joc.7b01467
https://doi.org/10.1021/acs.joc.7b01467
Publikováno v:
The Journal of Organic Chemistry. 81:3070-3075
The dearomatization of a series of electron-deficient nitrogen heterocycles has been achieved through a cobalt-catalyzed asymmetric cyclopropanation reaction. This reaction proceeds with high levels of enantio- and diastereoselectivity to afford uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8e3d35deace388c79107d4b59299b5
https://doi.org/10.1021/acs.joc.6b00322
https://doi.org/10.1021/acs.joc.6b00322
Autor:
Peter E. Maligres, Melodie Christensen, Christopher W. Plummer, Andrew Nolting, Louis-Charles Campeau, Robert K. Orr, Rebecca T. Ruck, Michael Shevlin, Joshua Lee, Matthew T. Tudge, Mark Weisel
Publikováno v:
The Journal of Organic Chemistry. 81:824-830
α- and β-substitution of dihydrocinnamates has been shown to increase the biological activity of various drug candidates. Recently, we identified enantio- and diastereopure α-methyl-β-cyclopropyldihydrocinnamates to be important pharmacophores in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f16e813693130a52b0f53abf5a3b73
https://doi.org/10.1021/acs.joc.5b02296
https://doi.org/10.1021/acs.joc.5b02296
Autor:
Damian P. Hruszkewycz, Patrick R. Melvin, Wei Dai, Nilay Hazari, Hemali P. Shah, Ainara Nova, Matthew T. Tudge, David Balcells
Publikováno v:
ACS Catalysis. 5:3680-3688
We describe the development of (η3-1-tBu-indenyl)2(μ-Cl)2Pd2, a versatile precatalyst scaffold for Pd-catalyzed cross-coupling. Our new system is more active than commercially available (η3-cinnamyl)2(μ-Cl)2Pd2 and is compatible with a range of N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f04c58aa2673f9428f92204845a33807
https://doi.org/10.1021/acscatal.5b00878
https://doi.org/10.1021/acscatal.5b00878
Autor:
Jordan M. Hoyt, Grant W. Margulieux, Shane W. Krska, Matthew T. Tudge, Michael Shevlin, Paul J. Chirik
Publikováno v:
Organometallics. 33:5781-5790
The activity of bis(phosphine) iron dialkyl complexes for the asymmetric hydrogenation of alkenes has been evaluated. High-throughput experimentation was used to identify suitable iron–phosphine combinations using the displacement of pyridine from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d03ad51ad617d945d8d489d9cbc08e
https://doi.org/10.1021/om500329q
https://doi.org/10.1021/om500329q
Autor:
Matthew T. Tudge, Ting Zhang
Publikováno v:
Tetrahedron Letters. 56:2329-2331
A new palladacycle precatalyst ( J009 PreCat ) was designed and synthesized. The precatalyst dramatically improved the yield of a class of extremely challenging cross-coupling reactions between functionalized heteroaryl chlorides and electron-deficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59dcdfb5ac8ea2c365996a269d1d89c4
https://doi.org/10.1016/j.tetlet.2015.03.080
https://doi.org/10.1016/j.tetlet.2015.03.080
Autor:
Shane W. Krska, Michael Shevlin, Paul J. Chirik, Jordan M. Hoyt, Max R. Friedfeld, Matthew T. Tudge
Publikováno v:
Science. 342:1076-1080
Lighter Hydrogenation Catalysts Enzymes have evolved to use abundant metals such as iron, cobalt, and nickel for redox catalysis. However, synthetic catalysis has generally relied on the rarer, heavier relatives of these elements: ruthenium, rhodium,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748d9408fa218ca7751bc1d1e91863b4
https://doi.org/10.1126/science.1243550
https://doi.org/10.1126/science.1243550
Autor:
Jason R. Schmink, Matthew T. Tudge
Publikováno v:
Tetrahedron Letters. 54:15-20
A palladium-catalyzed cross coupling of nitrogen bearing heterocyclic chloromethyl derivatives with aryl and heteroaryl boronic acids has been developed. In almost all cases, highly efficient cross-couplings were observed at ambient temperature, miti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c1357ae1b13db9d0d290f7cda335813
https://doi.org/10.1016/j.tetlet.2012.09.112
https://doi.org/10.1016/j.tetlet.2012.09.112
Publikováno v:
ChemInform. 47
Various fused nitrogen containing heteroarenes, including electron-deficient ones, are cyclopropanated in a highly diastereoselective and enantioselective manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9f83e9a2a1e817f5e67c2529d7aa2de
https://doi.org/10.1002/chin.201634036
https://doi.org/10.1002/chin.201634036