Výsledky vyhledávání - "Matthew T. Reding"

Novel Metabolic Bioactivation Mechanism for a Series of Anti-Inflammatory Agents (2,5-Diaminothiophene Derivatives) Mediated by Cytochrome P450 Enzymes

Autor: Shengtian Yang, Russell H. Robins, Kathy M. Mandrell, F. Barclay Shilliday, Bruce R. Heyde, Yurong Lai, Yiding Hu, Matthew T. Reding, David C. Thompson, Jin Xie

Publikováno v: Drug Metabolism and Disposition. 38:1522-1531

The thiophene moiety is considered a structural alert in molecular design in drug discovery, largely because several thiophene-containing drugs, including tienilic acid and suprofen, have been withdrawn from the market because of toxicities. Reactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa079f94506b5151907c2e5f9b9baffc
https://doi.org/10.1124/dmd.110.032581

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Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid

Autor: Funk Lee Andrew, Robert Anstadt, Rebecca M. Anderson, Jeffrey A. Pfefferkorn, Matthew T. Reding, Richard A. Nugent, Robert E. Kilkuskie, John A. Shelly, Francis J. Schwende, Melissa S. Harris, Mark A. Mitchell, Meredith Greene, Barry C. Finzel, Laurice A. Kopta, Peter A. Wells, Rebecca J. Gross

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:2481-2486

A novel series of nonnucleoside HCV NS5B polymerase inhibitors were prepared from (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid, a high throughput screening lead. SAR studies combined with structure based drug design focusing on the southern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb50dc565e73f2cfc26b76321b19bc0
https://doi.org/10.1016/j.bmcl.2005.03.066

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Recent developments in hepatitis C antiviral research 1999 - 2000

Autor: Matthew T. Reding

Publikováno v: Expert Opinion on Therapeutic Patents. 10:1201-1220

The exponential increase in the number of publications related to hepatitis C antiviral research both from academia and the pharmaceutical industry in recent years highlights the intense interest in combating this pathogen. The number of people infec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::118c6475a0545ae2ae5217bec342ec47
https://doi.org/10.1517/13543776.10.8.1201

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Stereocontrolled Total Synthesis of (±)-Catharanthine via Radical-Mediated Indole Formation

Autor: Tohru Fukuyama, Matthew T. Reding† and

Publikováno v: Organic Letters. 1:973-976

A stereocontrolled total synthesis of (±)-catharanthine, 1, has been completed. The key step involves the radical-mediated cyclization of a highly functionalized intermediate to furnish the corresponding indole. The cyclization utilizes a simple pho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b19912ca8ce1e31431b806db8e2bf803
https://doi.org/10.1021/ol990749i

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Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship

Autor: Matthew T. Reding, Horng-Chih Huang, Sumathy Mathialagan, Neetu Venkatraman, Jin Xie, Xiong Li, Sarah J. Brustkern, Gennadiy Poda, Shaun R. Selness, Serge G. Wolfson, Cynthia D. Sommers, Natalie X. Chen, Lori Christine, Yiding Hu, Nandini Kishore, Ravi G. Kurumbail, Sheri L. Bonar, Richard F. Heier, Patrick J. Lennon

Publikováno v: Bioorganicmedicinal chemistry. 19(3)

Installation of sites for metabolism in the lead compound PHA-767408 was the key focus of the IKK-2 inhaled program. This paper reports our efforts to identify a novel series of aminopyridinecarboxamide-based IKK-2 inhibitors, which display low nanom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f208e64a4c631435dcaa7ad7dfeaa04
https://pubmed.ncbi.nlm.nih.gov/21236687

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ChemInform Abstract: Short Enantioselective Total Syntheses of the Piperidine Alkaloids (S)-Coniine and (2R,6R)-trans-Solenopsin A via Catalytic Asymmetric Imine Hydrosilylation

Autor: Stephen L. Buchwald, Matthew T. Reding

Publikováno v: ChemInform. 30

The enantioselective syntheses of (S)-coniine and (2R,6R)-trans-solenopsin A are reported. The key step in both syntheses is the catalytic asymmetric hydrosilylation of a cyclic imine.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb27a5d6d89a3eb650a85c4cb21d6735
https://doi.org/10.1002/chin.199907245

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