Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Matthew T. O'Neill"'
Autor:
Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W. J. Steel, Cindy Evelyn, Matthew T. O’Neill, Niccolay Madiedo Soler, Nichollas E. Scott, Kelly L. Rogers, Ethan D. Goddard-Borger, Justin A. Boddey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Here, Lopaticki et al. show that Plasmodium falciparum expresses a Dpy19 C-mannosyltransferase in the endoplasmic reticulum that glycosylates TSR domains. Functional characterization shows that PfDpy19 plays a critical role in transmission through mo
Externí odkaz:
https://doaj.org/article/12ab71e7ba9140d7bae04bd201a04afe
Autor:
Ester Lopez, Ebene R. Haycroft, Amy Adair, Francesca L. Mordant, Matthew T. O’Neill, Phillip Pymm, Samuel J. Redmond, Wen Shi Lee, Nicholas A. Gherardin, Adam K. Wheatley, Jennifer A. Juno, Kevin J. Selva, Samantha K. Davis, Samantha L. Grimley, Leigh Harty, Damian F.J. Purcell, Kanta Subbarao, Dale I. Godfrey, Stephen J. Kent, Wai-Hong Tham, Amy W. Chung
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly evolving domains, which can result in the emergence of immune escape mutations, limiting the effectiveness of vaccines an
Externí odkaz:
https://doaj.org/article/6496c3fb4c0b4160a25ed36ea7212210
Autor:
Sash Lopaticki, Robyn McConville, Alan John, Niall Geoghegan, Shihab Deen Mohamed, Lisa Verzier, Ryan W. J. Steel, Cindy Evelyn, Matthew T. O’Neill, Niccolay Madiedo Soler, Nichollas E. Scott, Kelly L. Rogers, Ethan D. Goddard-Borger, Justin A. Boddey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/650355aa05664478856353f7c1630676
Autor:
Charlie Jennison, Leonardo Lucantoni, Matthew T. O’Neill, Robyn McConville, Sara M. Erickson, Alan F. Cowman, Brad E. Sleebs, Vicky M. Avery, Justin A. Boddey
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3796-3806.e4 (2019)
Summary: Plasmodium falciparum gametocytes infect mosquitoes and are responsible for malaria transmission. New interventions that block transmission could accelerate malaria elimination. Gametocytes develop within erythrocytes and activate protein ex
Externí odkaz:
https://doaj.org/article/6043059db5da4594912be1fa76539835
Autor:
Sash Lopaticki, Annie S. P. Yang, Alan John, Nichollas E. Scott, James P. Lingford, Matthew T. O’Neill, Sara M. Erickson, Nicole C. McKenzie, Charlie Jennison, Lachlan W. Whitehead, Donna N. Douglas, Norman M. Kneteman, Ethan D. Goddard-Borger, Justin A. Boddey
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and
Externí odkaz:
https://doaj.org/article/09e0a0fb76224df8a67b76f39e4a21ef
Autor:
Annie S.P. Yang, Matthew T. O’Neill, Charlie Jennison, Sash Lopaticki, Cody C. Allison, Jennifer S. Armistead, Sara M. Erickson, Kelly L. Rogers, Andrew M. Ellisdon, James C. Whisstock, Rebecca E. Tweedell, Rhoel R. Dinglasan, Donna N. Douglas, Norman M. Kneteman, Justin A. Boddey
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3105-3116 (2017)
Malaria sporozoites are deposited into the skin by mosquitoes and infect hepatocytes. The molecular basis of how Plasmodium falciparum sporozoites migrate through host cells is poorly understood, and direct evidence of its importance in vivo is lacki
Externí odkaz:
https://doaj.org/article/c5e848ec4e7c450ba45671fa5262bdfc
Autor:
Justin A. Boddey, Matthew T. O’Neill, Sash Lopaticki, Teresa G. Carvalho, Anthony N. Hodder, Thomas Nebl, Stephan Wawra, Pieter van West, Zeinab Ebrahimzadeh, Dave Richard, Sven Flemming, Tobias Spielmann, Jude Przyborski, Jeff J. Babon, Alan F. Cowman
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Export of Plasmodium falciparum proteins into infected erythrocytes relies upon the PEXEL motif in target proteins. Here Boddey et al.challenge the hypothesis that the PEXEL motif mediates export by binding PI(3)P and instead suggest it acts via clea
Externí odkaz:
https://doaj.org/article/9c31a074ac774adfad666d242b4d3b61
Autor:
Melanie H. Dietrich, Mikha Gabriela, Kitsanapong Reaksudsan, Matthew W. A. Dixon, Li-Jin Chan, Amy Adair, Stephanie Trickey, Matthew T. O'Neill, Li Lynn Tan, Sash Lopaticki, Julie Healer, Sravya Keremane, Alan F. Cowman, Wai-Hong Tham
Publikováno v:
Biochemical Journal. 479:2529-2546
Transmission blocking interventions can stop malaria parasite transmission from mosquito to human by inhibiting parasite infection in mosquitos. One of the most advanced candidates for a malaria transmission blocking vaccine is Pfs230. Pfs230 is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8200538f8b6130bb0907cba51ccb49
https://doi.org/10.1042/bcj20220554
https://doi.org/10.1042/bcj20220554
Autor:
Melanie H Dietrich, Li-Jin Chan, Amy Adair, Coralie Boulet, Matthew T O'Neill, Li Lynn Tan, Sravya Keremane, Yee-Foong Mok, Alvin W Lo, Paul Gilson, Wai-Hong Tham
Publikováno v:
FEMS Microbes. 3
During the different stages of the Plasmodium life cycle, surface-associated proteins establish key interactions with the host and play critical roles in parasite survival. The 6-cysteine (6-cys) protein family is one of the most abundant surface ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::722795543a49c30772bb6f934c27d6a1
https://doi.org/10.1093/femsmc/xtac005
https://doi.org/10.1093/femsmc/xtac005
Autor:
Melanie H, Dietrich, Li-Jin, Chan, Amy, Adair, Coralie, Boulet, Matthew T, O'Neill, Li Lynn, Tan, Sravya, Keremane, Yee-Foong, Mok, Alvin W, Lo, Paul, Gilson, Wai-Hong, Tham
Publikováno v:
FEMS microbes. 3
During the different stages of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3277fe5158ab3ee3eaf046394aeab48b
https://pubmed.ncbi.nlm.nih.gov/35308105
https://pubmed.ncbi.nlm.nih.gov/35308105