Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Matthew T. K. Kirkcaldie"'
Publikováno v:
IEEE Access, Vol 9, Pp 161926-161936 (2021)
Identification of amyloid beta ( $\text{A}\beta$ ) plaques in the cerebral cortex in models of Alzheimer’s Disease (AD) is of critical importance for research into therapeutics. Here we propose an innovative framework which automatically measures $
Externí odkaz:
https://doaj.org/article/703dd58d21f041c683adf2471ded7c3d
Publikováno v:
Journal of Open Research Software, Vol 5, Iss 1 (2017)
Image segmentation is a necessary step in automated quantitative imaging. ImageSURF is a macro-compatible ImageJ2/FIJI plugin for pixel-based image segmentation that considers a range of image derivatives to train pixel classifiers which are then app
Externí odkaz:
https://doaj.org/article/012a9cec40a84623a5dd2344f76707ba
Publikováno v:
Brain Structure and Function. 226:2041-2055
The calcium binding protein parvalbumin is expressed in interneurons of two main morphologies, the basket and chandelier cells, which target perisomatic domains on principal cells and are extensively interconnected in laminar networks by synapses and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09c987dea3215f9d8dfee2fd29971bb2
https://doi.org/10.1007/s00429-021-02327-3
https://doi.org/10.1007/s00429-021-02327-3
Autor:
James C. Vickers, Rachel A.K. Atkinson, James Bender, Anna E. King, Matthew T. K. Kirkcaldie, Jacqueline Y. K. Leung
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 2 (2021)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
Mislocalization of the TAR DNA-binding protein 43 (TDP-43; encoded by TARDBP) from the nucleus to the cytoplasm is a common feature of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0e2148ba7d7d5aac05b60101ff9935
https://doi.org/10.1242/dmm.047548
https://doi.org/10.1242/dmm.047548
Publikováno v:
Journal of neurotrauma. 36(11)
Traumatic brain injury (TBI) has been identified as a risk factor for Alzheimer's disease (AD). However, how such neural damage contributes to AD pathology remains unclear; specifically, the relationship between the timing of a TBI relative to aging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093778feaa27217b4d9ec9b9998af661
https://pubmed.ncbi.nlm.nih.gov/30623730
https://pubmed.ncbi.nlm.nih.gov/30623730
Publikováno v:
Journal of Chemical Neuroanatomy. 76:9-18
The physical structure of neurons - dendrites converging on the soma, with an axon conveying activity to distant locations - is uniquely tied to their function. To perform their role, axons need to maintain structural precision in the soft, gelatinou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba061b2db11d23eb845f8fddd8931dba
https://doi.org/10.1016/j.jchemneu.2016.05.006
https://doi.org/10.1016/j.jchemneu.2016.05.006
Publikováno v:
Molecular and cellular neurosciences. 84
Intermediate filaments are critical for the extreme structural specialisations of neurons, providing integrity in dynamic environments and efficient communication along axons a metre or more in length. As neurons mature, an initial expression of nest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a9210d7b286b8abce0d8efdc953d2c
https://pubmed.ncbi.nlm.nih.gov/28554564
https://pubmed.ncbi.nlm.nih.gov/28554564
The study of developmental gene expression has exposed major errors in traditional representations of brain stem organization. The major misunderstandings concern the status of the isthmus, the pons, and the pretectal area. The isthmus is the most ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73a9839f68b2843f0b0dce0c482fdbe5
https://doi.org/10.1016/b978-0-12-804042-3.00138-x
https://doi.org/10.1016/b978-0-12-804042-3.00138-x
Publikováno v:
Neurobiology of Aging. 34:2341-2351
Amyloid-β (Aβ) plaque accumulation in Alzheimer's disease (AD) is associated with glutamatergic synapse loss, but less is known about its effect on inhibitory synapses. Here, we demonstrate that vesicular γ-aminobutyric acid (GABA) transporter (VG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3beed5011de13f10371a185a7e3f961
https://doi.org/10.1016/j.neurobiolaging.2013.04.010
https://doi.org/10.1016/j.neurobiolaging.2013.04.010
Autor:
Olivier Bibari, Yao Liu, James C. Vickers, Jerome A. Staal, Matthew T. K. Kirkcaldie, Stan Mitew, Anna E. King, Tracey C. Dickson, Alison J. Canty
Publikováno v:
Journal of Comparative Neurology. 521:1817-1827
The neurofilament light (NFL) subunit is considered as an obligate subunit polymer for neuronal intermediate filaments comprising the neurofilament (NF) triplet proteins. We examined cytoskeletal protein levels in the cerebral cortex of NFL knockout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9a2609e977ea4d37cf3db2b5b42f431
https://doi.org/10.1002/cne.23261
https://doi.org/10.1002/cne.23261