Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Matthew T. Honaker"'
Autor:
Sara Eyal, Danny D. Shen, Mary F. Hebert, Brian Phillips, Kenneth E. Thummel, Gary D.V. Hankins, Matthew T. Honaker, Linda J. Risler, Erik Rytting, Edward J. Kelly, Raman Venkataraman, Rachel J. Ryu, Thomas R. Easterling, Steve N. Caritis
Publikováno v:
The Journal of Clinical Pharmacology. 56:581-589
The objective of this study was to evaluate the steady-state pharmacokinetics of metoprolol during pregnancy and lactation. Serial plasma, urine, and breast milk concentrations of metoprolol and its metabolite, α-hydroxymetoprolol, were measured ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83d2ef6cebac03a8dcf1f4bd1b42bcb
https://doi.org/10.1002/jcph.631
https://doi.org/10.1002/jcph.631
Autor:
Kenneth E. Thummel, Matthew T. Honaker, Karen Hays, Raman Venkataramanan, Ira Kantrowitz-Gordon, Jason G. Umans, Mary F. Hebert, Brooke Bennett, Steve N. Caritis, Thomas R. Easterling, Shannon M. Clark, Rachel J. Ryu, Danny D. Shen, Mahmoud Ahmed
Publikováno v:
Journal of clinical pharmacology. 58(9)
To evaluate the steady-state pharmacokinetics of prednisone and its metabolite prednisolone in pregnant and lactating female subjects, 19 subjects received prednisone (4-40 mg/day orally) in early (n = 3), mid (n = 9), and late (n = 13) pregnancy as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c2b26b9945d2ec935fc048372995be
https://pubmed.ncbi.nlm.nih.gov/29733485
https://pubmed.ncbi.nlm.nih.gov/29733485
Publikováno v:
Journal of Biological Chemistry. 288:18599-18611
The role of conformational ensembles in enzymatic reactions remains unclear. Discussion concerning "induced fit" versus "conformational selection" has, however, ignored detoxication enzymes, which exhibit catalytic promiscuity. These enzymes dominate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ab523b30294799e5a31cdd4f49511a
https://doi.org/10.1074/jbc.m112.445767
https://doi.org/10.1074/jbc.m112.445767
Publikováno v:
Journal of Biological Chemistry. 286:42770-42776
Enzymological paradigms have shifted recently to acknowledge the biological importance of catalytic promiscuity. However, catalytic promiscuity is a poorly understood property, and no thermodynamic treatment has described the conformational landscape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::357a517d0f1cbffd6c6cee1ef5022fac
https://doi.org/10.1074/jbc.m111.304386
https://doi.org/10.1074/jbc.m111.304386
Autor:
Josh T. Pearson, Robert S. Foti, Abhinav Nath, William M. Atkins, Nina Isoherranen, Matthew T. Honaker, Brian Buttrick
Publikováno v:
Biochemistry. 50:2387-2393
Promiscuity at the molecular level plays a critical role in several cellular processes including signal transduction, immunity, and detoxification (1–9). More broadly, the evolution of new enzymatic activities from a pool of existing protein scaffo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4758e44ec4a27d9852739f40121053
https://doi.org/10.1021/bi1020716
https://doi.org/10.1021/bi1020716
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 179:277-283
A mild and efficient method for the synthesis of ditertiary phosphines has been developed. In the presence of cesium hydroxide, molecular sieves, and DMF, various dihalides were coupled with diphenylphosphine at room temperature, and the results have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295e2a949da4923d855d4f70634e82ac
https://doi.org/10.1080/10426500490262261
https://doi.org/10.1080/10426500490262261
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706ee729dcce3a6af8e21395143cb32d
https://doi.org/10.1002/chin.200741262
https://doi.org/10.1002/chin.200741262
Autor:
William M. Atkins, Larissa M. Balogh, Liming Hou, Kei Cheuk Ng, Abhinav Nath, Laura M. Shireman, Arthur G. Roberts, Matthew T. Honaker
Publikováno v:
The Journal of biological chemistry. 282(32)
The structurally related glutathione S-transferase isoforms GSTA1-1 and GSTA4-4 differ greatly in their relative catalytic promiscuity. GSTA1-1 is a highly promiscuous detoxification enzyme. In contrast, GSTA4-4 exhibits selectivity for congeners of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471f98cd4e1020845179b4dc6db87f61
https://pubmed.ncbi.nlm.nih.gov/17561509
https://pubmed.ncbi.nlm.nih.gov/17561509
Autor:
Matthew T. Honaker, Benjamin J. Sandefur, Ralph Nicholas Salvatore, Alicia L. McDaniel, James L. Hargett
Publikováno v:
ChemInform. 35
A mild and efficient method for the synthesis of tertiary phosphines and ditertiary phosphines has been developed. In the presence of cesium hydroxide, molecular sieves and DMF at room temperature, various secondary phosphines and alkyl bromides were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a50602973da76c9a6066eae9e8eb26
https://doi.org/10.1002/chin.200408170
https://doi.org/10.1002/chin.200408170