Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Matthew T. Flowers"'
Autor:
Maggie S. Burhans, Matthew T. Flowers, Kristin R. Harrington, Laura M. Bond, Chang-An Guo, Rozalyn M. Anderson, James M. Ntambi
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 304-318 (2015)
Hepatic steatosis is associated with detrimental metabolic phenotypes including enhanced risk for diabetes. Stearoyl-CoA desaturases (SCDs) catalyze the synthesis of MUFAs. In mice, genetic ablation of SCDs reduces hepatic de novo lipogenesis (DNL) a
Externí odkaz:
https://doaj.org/article/e9f1adffbc594e2eb94fd5c1d2a03dfa
Autor:
Michael P. Rogowski, Matthew T. Flowers, Alexis D. Stamatikos, James M. Ntambi, Chad M. Paton
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2636-2646 (2013)
Stearoyl-CoA desaturase (SCD)1 converts saturated fatty acids into monounsaturated fatty acids. Using muscle overexpression, we sought to determine the role of SCD1 expression in glucose and lipid metabolism and its effects on exercise capacity in mi
Externí odkaz:
https://doaj.org/article/2c9be1146ec04463aad3190d3391d5e0
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1646-1653 (2012)
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the synthesis of monounsaturated fatty acids (MUFA) from saturated FA. Mice with whole-body or skin-specific deletion of SCD1 are resistant to obesity. Here, we show that mice lacking SCD1 in adipose and/or
Externí odkaz:
https://doaj.org/article/b5d24d6f985149c6aa38d9152109f48f
Autor:
Matthew T. Flowers, Albert K. Groen, Angie Tebon Oler, Mark P. Keller, YounJeong Choi, Kathryn L. Schueler, Oliver C. Richards, Hong Lan, Makoto Miyazaki, Folkert Kuipers, Christina M. Kendziorski, James M. Ntambi, Alan D. Attie
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 12, Pp 2668-2680 (2006)
Stearoyl-coenzyme A desaturase 1-deficient (SCD1−/−) mice have impaired MUFA synthesis. When maintained on a very low-fat (VLF) diet, SCD1−/− mice developed severe hypercholesterolemia, characterized by an increase in apolipoprotein B (apoB)-
Externí odkaz:
https://doaj.org/article/618112f2e3404c9baa54331c090f078e
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 2, Pp 225-234 (2001)
In this report we show the existence of a distinct pool of fat body diacylglycerol (DG) that can be distinguished from the bulk DG. This is a dynamic pool of DG that uses FA entering the fat body from the hemolymph, whereas the bulk DG uses the fatty
Externí odkaz:
https://doaj.org/article/b022e60c259c4058b89c0e2035b4bb0e
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 3, Pp 556-564 (1999)
We have previously shown that stereospecific hydrolysis of stored triacylglycerol by a phosphorylatable triacylglycerol-lipase is the pathway for the adipokinetic hormone-stimulated synthesis of sn-1, 2-diacylglycerol in insect fat body. The current
Externí odkaz:
https://doaj.org/article/1a37cfa4eedf490fa916c9d1fcf3e591
Autor:
Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, Krishanu Saha, Jon Levine, Marina E. Emborg, Shaoqin Gong
Genome editing of somatic cells via clustered regularly interspaced short palindromic repeats (CRISPR) offers promise for new therapeutics to treat a variety of genetic disorders, including neurological diseases. However, the dense and complex parenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3377092d36e7a30c1410b12546007251
https://doi.org/10.1101/2022.07.24.501299
https://doi.org/10.1101/2022.07.24.501299
Autor:
Marissa Kraynak, Molly M Willging, Alex L Kuehlmann, Amita A Kapoor, Matthew T Flowers, Ricki J Colman, Jon E Levine, David H Abbott
Publikováno v:
Journal of the Endocrine Society. 6
Context Ovarian estradiol supports female sexual behavior and metabolic function. While ovariectomy (OVX) in rodents abolishes sexual behavior and enables obesity, OVX in nonhuman primates decreases, but does not abolish, sexual behavior, and inconsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d06246c39940f2f2dbd98ccb31361da
https://doi.org/10.1210/jendso/bvac063
https://doi.org/10.1210/jendso/bvac063
Autor:
Jeanette M. Metzger, Yuyuan Wang, Samuel S. Neuman, Kathy J. Snow, Stephen A. Murray, Cathleen M. Lutz, Viktoriya Bondarenko, Jesi Felton, Kirstan Gimse, Ruosen Xie, Dongdong Li, Yi Zhao, Matthew T. Flowers, Heather A. Simmons, Subhojit Roy, Krishanu Saha, Jon E. Levine, Marina E. Emborg, Shaoqin Gong
Publikováno v:
Biomaterials. 293:121959
Genome editing of somatic cells via clustered regularly interspaced short palindromic repeats (CRISPR) offers promise for new therapeutics to treat a variety of genetic disorders, including neurological diseases. However, the dense and complex parenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50617b23e383b862d7ecaa0315451751
https://doi.org/10.1016/j.biomaterials.2022.121959
https://doi.org/10.1016/j.biomaterials.2022.121959
Autor:
Molly M Willging, Jon E. Levine, Emily P. Greinwald, Ricki J. Colman, Matthew T. Flowers, David H. Abbott
Publikováno v:
Journal of the Endocrine Society
Declining serum estradiol (E2) levels during the menopausal transition are associated with increased central adiposity and heightened risk for metabolic disease. Estrogenic effects on adiposity and metabolism in female rodents are primarily mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ca8cec48cfa87dd5cb8584439a3825
http://europepmc.org/articles/PMC7209601
http://europepmc.org/articles/PMC7209601