Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Matthew T. Dickerson"'
Autor:
Sarah M. Graff, Arya Y. Nakhe, Prasanna K. Dadi, Matthew T. Dickerson, Jordyn R. Dobson, Karolina E. Zaborska, Chloe E. Ibsen, Regan B. Butterworth, Nicholas C. Vierra, David A. Jacobson
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113673- (2024)
Summary: Mitochondrial Ca2+ ([Ca2+]m) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca2+]m uptake is dependent on elevations in cytoplasmic Ca2+ ([Ca2+]c) and endoplasmic reticulum Ca2+ ([Ca2
Externí odkaz:
https://doaj.org/article/bafc4693a1fb4df690f3a63ad1e180e7
Autor:
Matthew T. Dickerson, Prasanna K. Dadi, Karolina E. Zaborska, Arya Y. Nakhe, Charles M. Schaub, Jordyn R. Dobson, Nicole M. Wright, Joshua C. Lynch, Claire F. Scott, Logan D. Robinson, David A. Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Gi/o protein-coupled receptors (Gi/o-GPCRs) limit β-cell insulin secretion by decreasing Ca2+ entry; however, the underlying mechanism has not been identified. Here, the authors show that Gi/o-GPCRs hyperpolarize mouse and human β-cell membrane pot
Externí odkaz:
https://doaj.org/article/eb23a693600e41d29543c852619dfa62
Autor:
Sarah M. Graff, Stephanie R. Johnson, Paul J. Leo, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Aideen M. McInerney-Leo, Mhairi Marshall, Karolina E. Zaborska, Charles M. Schaub, Matthew A. Brown, David A. Jacobson, Emma L. Duncan
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic disorders of impaired pancreatic β cell function. The mechanisms underlying MODY include β cell KATP channel dysfunction (e.g., KCNJ11 [MODY13] or ABCC8 [MODY12] muta
Externí odkaz:
https://doaj.org/article/33dbdc4478504d16946c60f7af11f097
Autor:
Karolina E. Zaborska, Prasanna K. Dadi, Matthew T. Dickerson, Arya Y. Nakhe, Ariel S. Thorson, Charles M. Schaub, Sarah M. Graff, Jade E. Stanley, Roy S. Kondapavuluru, Jerod S. Denton, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 42, Iss , Pp 101056- (2020)
Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monoca
Externí odkaz:
https://doaj.org/article/739b7a2b2b794efa9353527289b42407
Autor:
Nicholas C. Vierra, Matthew T. Dickerson, Kelli L. Jordan, Prasanna K. Dadi, Ketaki A. Kadare, Molly K. Altman, Sarah C. Milian, David A. Jacobson
Publikováno v:
Molecular Metabolism, Vol 9, Iss , Pp 84-97 (2018)
Objective: Single-cell RNA sequencing studies have revealed that the type-2 diabetes associated two-pore domain K+ (K2P) channel TALK-1 is abundantly expressed in somatostatin-secreting δ-cells. However, a physiological role for TALK-1 in δ-cells r
Externí odkaz:
https://doaj.org/article/1d9f371e00d5410b87f2af7f170d89cf
Autor:
Matthew T. Dickerson, Jonathan Evans
Many readers drawn into the heroic tales of J. R. R. Tolkien's imaginary world of Middle-earth have given little conscious thought to the importance of the land itself in his stories or to the vital roles played by the flora and fauna of that land. A
Autor:
Karolina E. Zaborska, Kelli L. Jordan, Ariel S. Thorson, Prasanna K. Dadi, Charles M. Schaub, Arya Y. Nakhe, Matthew T. Dickerson, Joshua C. Lynch, Adam J. Weiss, Jordyn R. Dobson, David A. Jacobson
Publikováno v:
Diabetes Obes Metab
AIM: To determine whether hyperpolarization-activated cyclic nucleotide-gated (HCN) channels impact glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) modulation of islet Ca(2+) handling and insulin secretion. METHODS: The impact of liraglutide (GLP-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fdab110582ef02ffb7bb0f51d09922
https://europepmc.org/articles/PMC9843726/
https://europepmc.org/articles/PMC9843726/
Autor:
Alex Montoya, Emirhan Tasoez, Holger Kramer, Olof Idevall-Hagren, S Neda Mousavy Gharavy, Steven Millership, Mark Ibberson, Ming Hu, Aida Martinez-Sanchez, Paul Gadue, Eleni Georgiadou, Isabelle Leclerc, Dominic J. Withers, Nikolay Ninov, Bryn M. Owen, Pauline Chabosseau, Grazia Pizza, David A. Jacobson, Matthew T. Dickerson, Fabian L. Cardenas-Diaz, Zenobia B. Mehta, Marianne Voz, Christophe Magnan, Céline Cruciani-Guglielmacci, Nicholas H. F. Fine, Guy A. Rutter
Publikováno v:
Diabetologia
Diabetologia, 2021, 64 (4), pp.850-864. ⟨10.1007/s00125-020-05350-x⟩
Diabetologia, 2021, 64 (4), pp.850-864. ⟨10.1007/s00125-020-05350-x⟩
Aims/hypothesis Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. While previous functional work has suggested roles for VPS13C and C2CD4A in disease development,
Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction
Autor:
Terunaga Nakagawa, Tyler L. Perfitt, Jason R. Stephenson, Xiaohan Wang, David A. Jacobson, Matthew T. Dickerson, Roger J. Colbran
Publikováno v:
J Neurosci
The activation of neuronal plasma membrane Ca2+channels stimulates many intracellular responses. Scaffolding proteins can preferentially couple specific Ca2+channels to distinct downstream outputs, such as increased gene expression, but the molecular
Publikováno v:
Endocrinology
Transitional hypoglycemia in normal newborns occurs in the first 3 days of life and has clinical features consistent with hyperinsulinism. We found a lower threshold for glucose-stimulated insulin secretion from freshly isolated embryonic day (E) 22