Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Matthew T. Chan"'
Autor:
Nathalie A. Djaja, Matthew T. Chang, Freya R. Beinart, Vivian M. Morris, Laura R. Ganser, Sua Myong
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106537- (2023)
Summary: Fused in sarcoma (FUS) is a nuclear RNA-binding protein. Mutations in FUS lead to the mislocalization of FUS from the nucleus to the cytosol and formation of pathogenic aggregates in neurodegenerative diseases including amyotrophic lateral s
Externí odkaz:
https://doaj.org/article/b2558fbab845424eaa5796f0e6cd0466
Autor:
Tripti Shrestha Bhattarai, Tambudzai Shamu, Alexander N. Gorelick, Matthew T. Chang, Debyani Chakravarty, Elena I. Gavrila, Mark T. A. Donoghue, JianJong Gao, Swati Patel, Sizhi Paul Gao, Margaret H. Reynolds, Sarah M. Phillips, Tara Soumerai, Wassim Abida, David M. Hyman, Alison M. Schram, David B. Solit, Lillian M. Smyth, Barry S. Taylor
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
How different oncogenic Akt mutants can affect the response to Akt inhibitors is currently unclear. Here, the authors analyse somatic mutations of Akt1-3 isoforms in several human cancers, investigate their oncogenic effects and therapeutic relevance
Externí odkaz:
https://doaj.org/article/2f4ee7e6727f4b59871619d4a10453d0
Autor:
Marko Mrkobrada, Michael D Hill, Matthew T Chan, Alben Sigamani, David Cowan, Andrea Kurz, Daniel I Sessler, Michael Jacka, Michelle M Graham, Martin J O’Donnel, Monidipa Dasgupta, Derek J Emery, Adrian W Gelb, Irene Gulka, Diane Heels-Ansdell, Gordon Guyatt, John Murkin, Demetrios J Sahlas, Sadeesh Srinathan, Phil St. John, Scott S Tsai, Emily Wendland, PJ Devereaux
Publikováno v:
Stroke. 44
Introduction: 200 million patients worldwide undergo noncardiac surgery every year. Overt stroke is a serious complication of noncardiac surgery with significant impact on duration and quality of life. In the non-surgical population, covert stroke is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bab5911f902c3e42f6746fe4e9fdbe3
https://doi.org/10.1161/str.44.suppl_1.atmp9
https://doi.org/10.1161/str.44.suppl_1.atmp9
Publikováno v:
Early Brain Injury or Cerebral Vasospasm ISBN: 9783709103555
Delayed ischemic neurological deficit or clinical vasospasm remained a major cause for delayed neurological morbidity and mortality for patients with aneurysmal subarachnoid hemorrhage (SAH). Magnesium is a cerebral vasodilator. In experimental model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d6258578453361c5980c6a111981555
https://doi.org/10.1007/978-3-7091-0356-2_31
https://doi.org/10.1007/978-3-7091-0356-2_31
Autor:
Avinashnarayan Venkatanarayan, Jason Liang, Ivana Yen, Frances Shanahan, Benjamin Haley, Lilian Phu, Erik Verschueren, Trent B. Hinkle, David Kan, Ehud Segal, Jason E. Long, Tony Lima, Nicholas P.D. Liau, Jawahar Sudhamsu, Jason Li, Christiaan Klijn, Robert Piskol, Melissa R. Junttila, Andrey S. Shaw, Mark Merchant, Matthew T. Chang, Donald S. Kirkpatrick, Shiva Malek
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110351- (2022)
Summary: KRAS, which is mutated in ∼30% of all cancers, activates the RAF-MEK-ERK signaling cascade. CRAF is required for growth of KRAS mutant lung tumors, but the requirement for CRAF kinase activity is unknown. Here, we show that subsets of KRAS
Externí odkaz:
https://doaj.org/article/fa5d3d0fa6ab4799a1b8b428959ad8e4
Progress is reported on a study of a new turbulence simulation technique based on an unaveraged, additive decomposition of the Navier-Stokes equations. The decomposition provides a natural separation of the governing equations into large- and small-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0ec330618a790f8b981ef49289a3f
https://doi.org/10.21236/ada223678
https://doi.org/10.21236/ada223678
Autor:
Matthew T Chan
Publikováno v:
Current Opinion in Anesthesiology; Oct2004, Vol. 17 Issue 5, p389-396, 8p