Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Matthew T. Burk"'
Publikováno v:
Journal of the American Chemical Society. 143:1126-1132
(-)-Lomaiviticin A (1) is a genotoxic C2-symmetric metabolite that arises from the formal dimerization of two bis(glycosylated) diazotetrahydrobenzo[b]fluorenes. Here we present a synthesis of the monomer 17 and its coupling to form (2S,2'S)-lomaivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e59dc53783311d71c1a6389342d77c
https://doi.org/10.1021/jacs.0c11960
https://doi.org/10.1021/jacs.0c11960
Publikováno v:
The Journal of Organic Chemistry
An investigation into the use of Lewis base catalysis for the enantioselective chlorolactonization of 1,2-disubstituted alkenoic acids is described. Two mechanistically distinct reaction pathways for catalytic chlorolactonization have been identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1e01675540f9bf13479ab3554daef7
http://europepmc.org/articles/PMC5100718
http://europepmc.org/articles/PMC5100718
Publikováno v:
Organic Process Research & Development. 22:108-110
The synthesis of (2-cyclooctyn-1-yloxy)acetic acid was enabled to allow for the simple and safe production of this material on multigram scale.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2436a9d0e02f281f1b2af8e0b921d82
https://doi.org/10.1021/acs.oprd.7b00275
https://doi.org/10.1021/acs.oprd.7b00275
Autor:
Scott E. Denmark, Matthew T. Burk
Publikováno v:
Chirality. 26:344-355
The development of a binary catalyst system for bromocycloetherification, consisting of an achiral Lewis base and a chiral Bronsted acid, is described in detail. The results of preliminary kinetic studies are also presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87dfa0ee183b99c4082282578eb9cb1f
https://doi.org/10.1002/chir.22259
https://doi.org/10.1002/chir.22259
Publikováno v:
Lewis Base Catalysis in Organic Synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ddf568b62e30b618afd7e13f73694f1
https://doi.org/10.1002/9783527675142.ch24
https://doi.org/10.1002/9783527675142.ch24
Publikováno v:
Angewandte Chemie. 124:11098-11113
Obwohl die Halogenierung von Alkenen seit Jahrhunderten bekannt ist, wurden enantioselektive Varianten dieser Reaktion erst vor kurzem entwickelt. Die in den vergangenen drei Jahren beschriebenen katalytischen enantioselektiven Varianten von Halogenf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f84cb01c8426a12873979b40127cd8
https://doi.org/10.1002/ange.201204347
https://doi.org/10.1002/ange.201204347
Autor:
Scott E. Denmark, Matthew T. Burk
Publikováno v:
Proceedings of the National Academy of Sciences. 107:20655-20660
Lewis base catalyzed bromo- and iodolactonization reactions have been developed and the effects of catalyst structure on rate and cyclization selectivity have been systematically explored. The effects of substrate structure on halolactonization react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b793a2c85595b1955971a6a8b617fea3
https://doi.org/10.1073/pnas.1005296107
https://doi.org/10.1073/pnas.1005296107
Publikováno v:
ChemInform. 46
The presented reaction gives alcohols bearing quaternary stereocenters in high yields and excellent diastereo- and enantioselectivities tolerating a broad scope of aliphatic and aromatic substituents on both, the aldehyde and ketene imine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd2edb369dc3fbc890f6b9d8dd324b60
https://doi.org/10.1002/chin.201506105
https://doi.org/10.1002/chin.201506105
The synthesis of 1-O-acetyl-3-O-(4-methoxybenzyl)-4-N-(9-fluorenylmethoxycarbonyl)-4-N-methyl-l-pyrrolosamine (7), which constitutes a protected form of the N,N-dimethyl-l-pyrrolosamine residues found within the antiproliferative bacterial metabolite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f865813510c6f34fbec207ce4f04fd2
https://europepmc.org/articles/PMC4472375/
https://europepmc.org/articles/PMC4472375/
Autor:
Scott E, Denmark, Matthew T, Burk
Publikováno v:
Chirality. 26(7)
The development of a binary catalyst system for bromocycloetherification, consisting of an achiral Lewis base and a chiral Brønsted acid, is described in detail. The results of preliminary kinetic studies are also presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d72a7c794c569bf74ee64985109c44c5
https://pubmed.ncbi.nlm.nih.gov/24395341
https://pubmed.ncbi.nlm.nih.gov/24395341