Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Matthew T. Blahna"'
Autor:
Peter A. Kaufman, Edward Neuberger, Naomi R. M. Schwartz, Shu Wang, Yutong Liu, Ling-I Hsu, Karen Bartley, Matthew T. Blahna, Brian T. Pittner, Gabriel Wong, Carey Anders
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundTucatinib is an oral human epidermal growth factor receptor 2 (HER2)-directed therapy approved in combination with trastuzumab and capecitabine for use in patients with previously treated HER2+ metastatic breast cancer (MBC) with/without br
Externí odkaz:
https://doaj.org/article/a623ee2eb0d84c878bd93dd042adc141
Autor:
Anubhav Nangia, Shaun Abeysinghe, Andres Forero-Torres, Kendra DeBusk, Adrian Vickers, Matthew T Blahna, Chiemeka Ike, Judith Bell
Publikováno v:
Future Oncology. 17:4635-4647
Aim: A systematic literature review and network meta-analysis of randomized controlled trials in patients receiving therapy for HER2+ unresectable/metastatic breast cancer after ≥1 HER2-directed therapy was conducted to compare progression-free sur
Autor:
Peter A. Kaufman, Edward Neuberger, Ling-I Hsu, Naomi Schwartz, Karen Bartley, Shu Wang, Yutong Liu, Matthew T. Blahna, Brian T. Pittner, Gabriel Wong, Carey Anders
Publikováno v:
Cancer Research. 83:P4-03
Background: Tucatinib is an oral HER2-targeted therapy that was approved by the FDA in April 2020 for use in combination with trastuzumab and capecitabine for treatment of patients with previously treated HER2+ metastatic breast cancer (MBC). In the
Autor:
Matthew R Jones, Matthew T Blahna, Elyse Kozlowski, Kori Y Matsuura, Joseph D Ferrari, Samantha A Morris, John T Powers, George Q Daley, Lee J Quinton, Joseph P Mizgerd
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003105 (2012)
The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem cell maintenance. It can uridylate mature miR-26 to
Externí odkaz:
https://doaj.org/article/9234bc57b7a149c190b41250e986f0b4
Autor:
Akiko Hata, Jean-Charles Neel, Justin Louie, Matthew T. Blahna, Ge Yu, Prajakta Ghatpande, Giorgio Lagna
Next-generation sequencing has uncovered microRNAs (miRNAs) that undergo sequence modifications, known as isomiRs. Their physiological significance, however, remains uncertain, partly because they generally comprise a small fraction of total miRNAs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188ba229ad883f6e704eff36aac7482e
Autor:
Darrell N. Kotton, Kazuko Yamamoto, Sarah J. Ohle, J. C. Jean, Andrew A. Wilson, Letty W. Kwok, Matthew T. Blahna, Sara Greenhill, Emily L. Porter, Julie G. Payne, Joseph P. Mizgerd, Gregory S McElroy
Publikováno v:
Molecular Therapy
Although RNA interference (RNAi) has become a ubiquitous laboratory tool since its discovery 12 years ago, in vivo delivery to selected cell types remains a major technical challenge. Here, we report the use of lentiviral vectors for long-term in viv
Autor:
Darrell N. Kotton, Matthew R. Jones, Fadie T. Coleman, Joseph P. Mizgerd, Kazuko Yamamoto, Stephen I. Pelton, Mary C Zabinski, Lee J. Quinton, Igor Kramnik, Andrew A. Wilson, Matthew T. Blahna, Hirofumi Kamata
Publikováno v:
The Journal of infectious diseases. 216(4)
During pneumococcal pneumonia, antibacterial defense requires the orchestrated expression of innate immunity mediators, initiated by alveolar macrophages and dependent on transcription driven by nuclear factor κB (NF-κB). Such immune pressure may s
Publikováno v:
Journal of Biological Chemistry. 286:42381-42389
Zcchc11 is a uridyltransferase protein with enzymatic activity directed against diverse RNA species. On the basis of its known uridylation targets, we hypothesized that Zcchc11 might regulate cell proliferation. Confirming this, loss-of-function and
Autor:
Dieter A. Wolf, Matthew R. Jones, Matthew T. Blahna, Alexander R. Ivanov, Joseph P. Mizgerd, Joel R. Neilson, Suneng Fu, Lee J. Quinton
Publikováno v:
Nature cell biology
Mounting an effective host immune response without incurring inflammatory injury requires the precise regulation of cytokine expression. To achieve this, cytokine mRNAs are post-transcriptionally regulated by diverse RNA-binding proteins and microRNA
Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice
Autor:
Xiaoling Zhang, Joseph P. Mizgerd, Vishakha Sabharwal, Shizuo Akira, Matthew T. Blahna, Lee J. Quinton, Stephen I. Pelton, Eri Allen, Roland M. Schmid, Joseph D. Ferrari, Avrum Spira, Hana Algül, Matthew R. Jones, Kristie L. Hilliard
The acute phase response is an evolutionarily conserved reaction in which physiological stress triggers the liver to remodel the blood proteome. Although thought to be involved in immune defense, the net biological effect of the acute phase response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213b32dde02e9900299d01f99109c9d7
https://europepmc.org/articles/PMC3336975/
https://europepmc.org/articles/PMC3336975/