Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Matthew T Witkowski"'
Autor:
Chao Ma, Weiqiang Chen, Lunan Liu, Zhuoyu Zhang, Matthew T Witkowski, Iannis Aifantis, Saba Ghassemi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)
Background Adaptive CD19-targeted chimeric antigen receptor (CAR) T-cell transfer has become a promising treatment for leukemia. Although patient responses vary across different clinical trials, reliable methods to dissect and predict patient respons
Externí odkaz:
https://doaj.org/article/0f7bed6b23064c45b3867d327a93ca03
Autor:
Gloria Paz Contreras Yametti, Nikki A Evensen, Jennifer Schloss, Clemence Aldebert, Emily Duan, Yan Zhang, Jiyuan Hu, Tiffany M Chambers, Michael E Scheurer, David T Teachey, Karen R Rabin, Elizabeth A. Raetz, Iannis Aifantis, William L Carroll, Matthew T Witkowski
Publikováno v:
Blood Advances.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7e444ac5061886fcd5138d09fb0470
https://doi.org/10.1182/bloodadvances.2023010044
https://doi.org/10.1182/bloodadvances.2023010044
Autor:
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J. Walker, Zhengxi Sun, Matthew T. Witkowski, Anastasia N. Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A. Obeng, Aristotelis Tsirigos, Richard M. Stone, John C. Byrd, Stanley Pounds, William L. Carroll, Tanja A. Gruber, Ann-Kathrin Eisfeld, Iannis Aifantis
Publikováno v:
Nature Cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::255f8b1701736d96c18336f43686c220
https://doi.org/10.1038/s43018-023-00518-x
https://doi.org/10.1038/s43018-023-00518-x
Autor:
Palaniraja Thandapani, Andreas Kloetgen, Matthew T. Witkowski, Christina Glytsou, Anna K. Lee, Eric Wang, Jingjing Wang, Sarah E. LeBoeuf, Kleopatra Avrampou, Thales Papagiannakopoulos, Aristotelis Tsirigos, Iannis Aifantis
Publikováno v:
Nature. 601:428-433
Although deregulation of transfer RNA (tRNA) biogenesis promotes the translation of pro-tumorigenic mRNAs in cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ef5f72d24ec5380ac741d5753784f7
https://doi.org/10.1038/s41586-021-04244-1
https://doi.org/10.1038/s41586-021-04244-1
Autor:
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J. Walker, Zhengxi Sun, Matthew T. Witkowski, Anastasia N. Tikhonova, Maria Guillamot-Ruano, Geraldine Cayanan, Anna Yeaton, Gabriel Robbins, Esther A. Obeng, Aristotelis Tsirigos, Richard M. Stone, John C. Byrd, Stanley Pounds, William L. Carroll, Tanja A. Gruber, Ann-Kathrin Eisfeld, Iannis Aifantis
Publikováno v:
Nat Cancer
Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and limited treatment options. Here we provide a comprehensive census of the bone marrow immune microenvironment in adult and pediatric patients with AML. We characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8747a8fd243871674fc5f3aaaff546c
https://europepmc.org/articles/PMC9986885/
https://europepmc.org/articles/PMC9986885/
Autor:
Matthew T. Witkowski, Soobeom Lee, Eric Wang, Anna K. Lee, Alexis Talbot, Chao Ma, Nikolaos Tsopoulidis, Justin Brumbaugh, Yaqi Zhao, Kathryn G. Roberts, Simon J. Hogg, Sofia Nomikou, Yohana E. Ghebrechristos, Palaniraja Thandapani, Charles G. Mullighan, Konrad Hochedlinger, Weiqiang Chen, Omar Abdel-Wahab, Justin Eyquem, Iannis Aifantis
Publikováno v:
Nature immunology, vol 23, iss 10
Nat Immunol
Nat Immunol
B cell progenitor acute lymphoblastic leukemia (B-ALL) treatment has been revolutionized by T cell-based immunotherapies-including chimeric antigen receptor T cell therapy (CAR-T) and the bispecific T cell engager therapeutic, blinatumomab-targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30f4b81441fb0cd11ee7899077251d6
https://escholarship.org/uc/item/03r3740v
https://escholarship.org/uc/item/03r3740v
Autor:
Audrey Lasry, Bettina Nadorp, Maarten Fornerod, Deedra Nicolet, Huiyun Wu, Christopher J Walker, Zhengxi Sun, Matthew T Witkowski, Anastasia N Tikhonova, Maria Guillamot, Geraldine Cayanan, Anna Yeaton, Tanja A Gruber, Ann-Kathrin Eisfeld, Iannis Aifantis
Publikováno v:
Blood Cancer Discovery. 4:A20-A20
Acute myeloid leukemia (AML) is a hematopoietic malignancy with poor prognosis and limited treatment options. Here we provide a comprehensive single cell RNA-Sequencing census of the bone marrow immune microenvironment in adult and pediatric AML pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c73dc027bf5c2ce035a524faa8d2ebd3
https://doi.org/10.1158/2643-3249.aml23-a20
https://doi.org/10.1158/2643-3249.aml23-a20
Autor:
Elena Battistello, Kimberlee Hixon, Dawn E. Comstock, Clayton K. Collings, Xufeng Chen, Javier Rodriguez Hernaez, Soobeom Lee, Konstantinos Ntatsoulis, Annamaria Cesarano, Kathryn Hockemeyer, W. Nicholas Haining, Matthew T. Witkowski, Jun Qi, Aristotelis Tsirigos, Fabiana Perna, Ioannis Aifantis, Cigall Kadoch
Publikováno v:
Cancer Research. 83:1794-1794
T cell activation and exhaustion are associated with highly coordinated changes in gene expression and chromatin accessibility. While the contribution of key, state-specific transcription factors to these processes has been extensively explored, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d16c914dee19a687161ece62c165aed
https://doi.org/10.1158/1538-7445.am2023-1794
https://doi.org/10.1158/1538-7445.am2023-1794
Autor:
Elena Battistello, Kimberlee A. Hixon, Dawn E. Comstock, Clayton K. Collings, Xufeng Chen, Javier Rodriguez Hernaez, Soobeom Lee, Kasey S. Cervantes, Madeline M. Hinkley, Konstantinos Ntatsoulis, Annamaria Cesarano, Kathryn Hockemeyer, W. Nicholas Haining, Matthew T. Witkowski, Jun Qi, Aristotelis Tsirigos, Fabiana Perna, Iannis Aifantis, Cigall Kadoch
Publikováno v:
Molecular Cell. 83:1216-1236.e12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bc8b6e0fa3ec51a231a3cb657ff8b72
https://doi.org/10.1016/j.molcel.2023.02.026
https://doi.org/10.1016/j.molcel.2023.02.026
Autor:
Eric Wang, Xiaoli Mi, Meghan C. Thompson, Skye Montoya, Ryan Q. Notti, Jumana Afaghani, Benjamin H. Durham, Alex Penson, Matthew T. Witkowski, Sydney X. Lu, Jessie Bourcier, Simon J. Hogg, Caroline Erickson, Dan Cui, Hana Cho, Michael Singer, Tulasigeri M. Totiger, Sana Chaudhry, Mark Geyer, Alvaro Alencar, Adam J. Linley, M. Lia Palomba, Catherine C. Coombs, Jae H. Park, Andrew Zelenetz, Lindsey Roeker, Mary Rosendahl, Donald E. Tsai, Kevin Ebata, Barbara Brandhuber, David M. Hyman, Iannis Aifantis, Anthony Mato, Justin Taylor, Omar Abdel-Wahab
Publikováno v:
N Engl J Med
BACKGROUND: Covalent (irreversible) Bruton’s tyrosine kinase (BTK) inhibitors have transformed the treatment of multiple B-cell cancers, especially chronic lymphocytic leukemia (CLL). However, resistance can arise through multiple mechanisms, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c7a6941c3658b12d6cb8c107f22ac2
https://europepmc.org/articles/PMC9074143/
https://europepmc.org/articles/PMC9074143/