Zobrazeno 1 - 10
of 267
pro vyhledávání: '"Matthew T Weirauch"'
Autor:
John B Harley, Viktoryia Laurynenka, Sreeja Parameswaran, Xiaoting Chen, Leah C Kottyan, Matthew T Weirauch, Kenneth M Kaufman, Iouri Chepelev
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/78b17783b62447819ce41c9c2d6c3904
Autor:
Tareian A Cazares, Faiz W Rizvi, Balaji Iyer, Xiaoting Chen, Michael Kotliar, Anthony T Bejjani, Joseph A Wayman, Omer Donmez, Benjamin Wronowski, Sreeja Parameswaran, Leah C Kottyan, Artem Barski, Matthew T Weirauch, V B Surya Prasath, Emily R Miraldi
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010863 (2023)
Transcription factors read the genome, fundamentally connecting DNA sequence to gene expression across diverse cell types. Determining how, where, and when TFs bind chromatin will advance our understanding of gene regulatory networks and cellular beh
Externí odkaz:
https://doaj.org/article/47ad65dfdd1a46f0b5c46cc8a247f53a
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss Suppl 3 (2022)
Externí odkaz:
https://doaj.org/article/d192378dd61f461e80eb0a2e7bf5ebb0
Autor:
Amy A Eapen, Sreeja Parameswaran, Carmy Forney, Lee E Edsall, Daniel Miller, Omer Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z Magier, Mario Pujato, Xiaoting Chen, Kenneth Kaufman, David I Bernstein, Ashley L Devonshire, Marc E Rothenberg, Matthew T Weirauch, Leah C Kottyan
Publikováno v:
PLoS Genetics, Vol 18, Iss 5, p e1009973 (2022)
Atopic dermatitis (AD) is one of the most common skin disorders among children. Disease etiology involves genetic and environmental factors, with 29 independent AD risk loci enriched for risk allele-dependent gene expression in the skin and CD4+ T ce
Externí odkaz:
https://doaj.org/article/5aaedcdbf87f4cd6875c58bb569fc698
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/c07ebd22e7e94aa59b3daf04f564227b
Autor:
Yi Kuang, Anna Pyo, Natanel Eafergan, Brittany Cain, Lisa M Gutzwiller, Ofri Axelrod, Ellen K Gagliani, Matthew T Weirauch, Raphael Kopan, Rhett A Kovall, David Sprinzak, Brian Gebelein
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009039 (2021)
Notch signaling controls many developmental processes by regulating gene expression. Notch-dependent enhancers recruit activation complexes consisting of the Notch intracellular domain, the Cbf/Su(H)/Lag1 (CSL) transcription factor (TF), and the Mast
Externí odkaz:
https://doaj.org/article/46e826c091ea4d9db920f08826b85963
Autor:
Matthew R Hass, Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Omer Donmez, Leah C Kottyan, Matthew T Weirauch, Raphael Kopan
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009574 (2021)
Runt-related transcription factor 1 (Runx1) can act as both an activator and a repressor. Here we show that CRISPR-mediated deletion of Runx1 in mouse metanephric mesenchyme-derived mK4 cells results in large-scale genome-wide changes to chromatin ac
Externí odkaz:
https://doaj.org/article/a61e659e34d045a0b33e892800ee2cb9
Autor:
Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, Samantha A Brugmann
Publikováno v:
eLife, Vol 9 (2020)
Despite a common understanding that Gli TFs are utilized to convey a Hh morphogen gradient, genetic analyses suggest craniofacial development does not completely fit this paradigm. Using the mouse model (Mus musculus), we demonstrated that rather tha
Externí odkaz:
https://doaj.org/article/659f921a3e85487a949e94d7fb166cc9
Autor:
Shreyasi Mukherjee, Praneet Chaturvedi, Scott A Rankin, Margaret B Fish, Marcin Wlizla, Kitt D Paraiso, Melissa MacDonald, Xiaoting Chen, Matthew T Weirauch, Ira L Blitz, Ken WY Cho, Aaron M Zorn
Publikováno v:
eLife, Vol 9 (2020)
Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. Sox17 is a key transcriptional regulator of definitive endoderm development, and yet
Externí odkaz:
https://doaj.org/article/099fd6889c844b1e940c404adbcee5ef
Autor:
Qiang Wang, Taehyeung Kim, Marta Martínez-Bonet, Vitor R. C. Aguiar, Sangwan Sim, Jing Cui, Jeffrey A. Sparks, Xiaoting Chen, Marc Todd, Brian Wauford, Miranda C. Marion, Carl D. Langefeld, Matthew T. Weirauch, Maria Gutierrez-Arcelus, Peter A. Nigrovic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Genome-wide association studies implicate multiple loci in risk for systemic lupus erythematosus (SLE), but few contain exonic variants, rendering systematic identification of non-coding variants essential to decoding SLE genetics. We utiliz
Externí odkaz:
https://doaj.org/article/1e3df32c4843408cb3495d4e0d4bcf9e