Zobrazeno 1 - 10
of 536
pro vyhledávání: '"Matthew T V, Chan"'
Autor:
Judeng Zeng, Chuan Xie, Ziheng Huang, Chi H. Cho, Hung Chan, Qing Li, Hassan Ashktorab, Duane T. Smoot, Sunny H. Wong, Jun Yu, Wei Gong, Cong Liang, Hongzhi Xu, Huarong Chen, Xiaodong Liu, Justin C. Y. Wu, Margaret Ip, Tony Gin, Lin Zhang, Matthew T. V. Chan, Wei Hu, William K. K. Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The role of N6-methyladenosine (m6A) modification of host mRNA during bacterial infection is unclear. Here, we show that Helicobacter pylori infection upregulates host m6A methylases and increases m6A levels in gastric epithelial cells. Redu
Externí odkaz:
https://doaj.org/article/faf3d02f8eca48d192ffb1a37c4210da
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionEmerging preclinical and clinical studies suggest that altered gut microbiome composition and functions are associated with coronavirus 2019 (COVID- 19) severity and its long-term complications. We hypothesize that COVID-19 outcome is ass
Externí odkaz:
https://doaj.org/article/38fd4c22b4c940dcb2027f6b0199e443
Autor:
Amit X. Garg, Meaghan Cuerden, Juan Cata, Matthew T. V. Chan, P. J. Devereaux, Edith Fleischmann, Ascensión Martín Grande, Barbara Kabon, Giovanni Landoni, Donna E. Maziak, Sean McLean MD, Chirag Parikh, Ekaterine Popova, Cara Reimer, Juan Carlos Trujillo Reyes, Pavel Roshanov, Daniel I. Sessler, Sadeesh Srinathan, Jessica M. Sontrop, Anna Gonzalez Tallada, Michael Ke Wang, Jennifer R. Wells, David Conen
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 10 (2023)
Background: Inflammation during and after surgery can lead to organ damage including acute kidney injury. Colchicine, an established inexpensive anti-inflammatory medication, may help to protect the organs from pro-inflammatory damage. This protocol
Externí odkaz:
https://doaj.org/article/60645a9184ac400b939f552bd0a0b3d6
Autor:
Maura Marcucci, Thomas W. Painter, David Conen, Kate Leslie, Vladimir V. Lomivorotov, Daniel Sessler, Matthew T. V. Chan, Flavia K. Borges, Maria J. Martínez Zapata, C. Y. Wang, Denis Xavier, Sandra N. Ofori, Giovanni Landoni, Sergey Efremov, Ydo V. Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Amit X. Garg, Timothy G. Short, Maria Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Emmanuelle Duceppe, Kurtz Ruetzler, Joel L. Parlow, Vikas Tandon, Michael K. Wang, Edith Fleischmann, Carisi A. Polanczyk, Raja Jayaram, Sergey V. Astrakov, Mangala Rao, Tomas VanHelder, William K. K. Wu, Chao Chia Cheong, Sabry Ayad, Marat Abubakirov, Mikhail Kirov, Keyur Bhatt, Miriam de Nadal, Valery Likhvantsev, Pilar Paniagua Iglesisas, Hector J. Aguado, Michael McGillion, Andre Lamy, Richard P. Whitlock, Pavel Roshanov, David Stillo, Ingrid Copland, Jessica Vincent, Kumar Balasubramanian, Shrikant I. Bangdiwala, Bruce Biccard, Andrea Kurz, Sadeesh Srinathan, Shirley Petit, John Eikelboom, Toby Richards, Peter L. Gross, Pascal Alfonsi, Gordon Guyatt, Emily Belley-Cote, Jessica Spence, William McIntyre, Salim Yusuf, P. J. Devereaux
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-12 (2022)
Abstract Background For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to r
Externí odkaz:
https://doaj.org/article/ac890204cd84433d8ed555ab388c2508
Autor:
Kate Leslie, Matthew T. V. Chan, Jai N. Darvall, Anurika P. De Silva, Sabine Braat, Nancy J. Devlin, Philip J. Peyton, Jade Radnor, Carmen K. M. Lam, Sofia Sidiropoulos, David A. Story
Publikováno v:
Pilot and Feasibility Studies, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract Background Sugammadex reduces residual neuromuscular blockade after anaesthesia, potentially preventing postoperative pulmonary complications. However, definitive evidence is lacking. We therefore conducted a feasibility and pilot trial for
Externí odkaz:
https://doaj.org/article/0b47a331b2e041a09913c75a80d34146
Autor:
Guy Haller, Matthew T. V. Chan, Christophe Combescure, Ursula Lopez, Isabelle Pichon, Marc Licker, Roxane Fournier, Paul Myles
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract There is a large controversy as to whether nitrous oxide (N2O) added to the anaesthetic gas mixture is harmful or harmless for postoperative cognitive function recovery. We performed a nested study in the ENIGMA-II trial and compared postope
Externí odkaz:
https://doaj.org/article/2135068b5f3a4e048e880ef43b129637
Autor:
Wenye Xu, Yingzhi Liu, Xuan Zou, Huanle Luo, Weihua Wu, Junjie Xia, Matthew T. V. Chan, Shisong Fang, Yuelong Shu, William K. K. Wu, Lin Zhang
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Zinc ion as an enzyme cofactor exhibits antiviral and anti-inflammatory activity during infection, but circulating zinc ion level during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is unclear. This study aimed to evaluate s
Externí odkaz:
https://doaj.org/article/0ec67a607a7742659e4f307cf78c26cc
Autor:
Derong Xu, Xuexiao Ma, Chong Sun, Jialuo Han, Chuanli Zhou, Sunny Hei Wong, Matthew T. V. Chan, William K. K. Wu
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Low back pain, a common medical condition, could result in severe disability and inflict huge economical and public health burden. Its pathogenesis is attributed to multiple etiological factors, including intervertebral disc degeneration (IDD). Emerg
Externí odkaz:
https://doaj.org/article/d0002bb94a3647fdbed8648a189047b8
Autor:
Ying Zhi Liu, Raymond Chu, Anna Lee, Charles David Gomersall, Lin Zhang, Tony Gin, Matthew T. V. Chan, William K. K. Wu, Lowell Ling
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Currently there are only two population studies on sepsis incidence in Asia. The burden of sepsis in Hong Kong is unknown. We developed a sepsis surveillance method to estimate sepsis incidence from a population electronic health
Externí odkaz:
https://doaj.org/article/4fd3a104770a4518a13acde8e2caab56
Autor:
Jeffery Ho, Hung Chan, Yonghao Liang, Xiaodong Liu, Lin Zhang, Qing Li, Yuchen Zhang, Judeng Zeng, Felix N. Ugwu, Idy H. T. Ho, Wei Hu, Johnny C. W. Yau, Sunny H. Wong, Wai Tat Wong, Lowell Ling, Chi H. Cho, Richard L. Gallo, Tony Gin, Gary Tse, Jun Yu, Matthew T. V. Chan, Czarina C. H. Leung, William K. K. Wu
Publikováno v:
Critical Care, Vol 24, Iss 1, Pp 1-16 (2020)
Abstract Objectives The intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies
Externí odkaz:
https://doaj.org/article/7d62813e15f84a7bb7e67e903aed1b8b